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Silibinin

Silibinin Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:TIANFU-CHEM Silibinin
CAS:22888-70-6
Purity:99% Package:25KG;5KG;1KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: +8615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:Silibinin fandachem
CAS:22888-70-6
Purity:As coa Package:As request Remarks:22888-70-6
Company Name: Nanjing Finetech Chemical Co., Ltd.
Tel: 025-85710122 17714198479
Email: sales@fine-chemtech.com
Products Intro: CAS:22888-70-6
Purity:99%min Package:1KG;10KG;100KG;500KG;100g Remarks:ISO certified
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Email: zheyansh@163.com
Products Intro: Product Name:Silibinin
CAS:22888-70-6
Purity:HPLC>=98% Package:20mg
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Silibinin
CAS:22888-70-6
Purity:98% Package:1KG;2USD

Silibinin manufacturers

  • Silibinin
  • $0.00 / 1KG
  • 2022-02-25
  • CAS:22888-70-6
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Silibinin
  • $0.00 / 1KG
  • 2021-09-29
  • CAS:22888-70-6
  • Min. Order: 1KG
  • Purity: 97.0%
  • Supply Ability: 50kg/month

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Silibinin Basic information
Product Name:Silibinin
Synonyms:Silybin-A ,98%;Silybin (50 mg);Silybin, 2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-6-(3,5,7-trihydroxy-4-oxobenzopyran-2-yl)benzodioxin;Silybin,Silymarin;(2R)-2α-[[(2R,3R)-2,3-Dihydro-3β-(4-hydroxy-3-methoxyphenyl)-2α-(hydroxymethyl)-1,4-benzodioxin]-6-yl]-2,3-dihydro-3β,5,7-trihydroxy-4H-1-benzopyran-4-one;(2R,3R)-2-[[(2R,3R)-2,3-Dihydro-3β-(4-hydroxy-3-methoxyphenyl)-2α-(hydroxymethyl)-1,4-benzodioxin]-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one;Flavobion;silliver
CAS:22888-70-6
MF:C25H22O10
MW:482.44
EINECS:245-302-5
Product Categories:Aromatics;Chiral Reagents;Angiogenesis InhibitorsCancer Research;Anti-proliferative AgentsNutrition Research;Angiogenesis;Biochemicals Found in Plants;Flavanones;Natural Plant Extract;Bioflavonoids;Cancer Research;Chemopreventive Agents;chemical reagent;Plant extract;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical raw material;Plant extracts;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:22888-70-6.mol
Silibinin Structure
Silibinin Chemical Properties
Melting point 164-174°C
alpha D20 +11° (c = 0.25 in acetone + alcohol)
Boiling point 793.0±60.0 °C(Predicted)
density 1.527±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Acetone (Sparingly), DMSO, Methano (Sparingly)
form Solid
pkapKa 6.42±0.04 (Uncertain)
color Pale Yellow
Water Solubility 54mg/L(24.99 ºC)
Merck 13,8607
Stability:Stable. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference22888-70-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39-24/25-22-36
RIDADR 3172
WGK Germany 3
RTECS DJ2981770
HS Code 29329990
ToxicityLD50 intravenous in mouse: 1056mg/kg
MSDS Information
Silibinin Usage And Synthesis
Chemical Propertiessolid
OriginatorLegalon,Madaus,W. Germany,1969
UsesLabelled Silybin (S465850). Hepatoprotectant.
UsesSilibinin has been used:
  • to study its effect on gene expression levels of various proteins involved in chromatin regulations of prostate cancer, by real time polymerase chain reaction (RT-PCR)
  • to study its effect on cell proliferation in platelet-derived growth factor (PDGF)-treated human tenon′s fibroblasts (HTFs) by investigating the expression of proliferating cell nuclear antigen (PCNA) and by water-soluble tetrazolium salt (WST-1) assay
  • to examine its effect on gene expression levels of stromelysine 1 (STM1), acetyl hexoseamines and collagen production during skin wound healing
  • to study its inhibitory effect on Escherichia coli ATP synthase

DefinitionChEBI: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
Manufacturing ProcessSilymarin comprising polyhydroxyphenyl chromanones is recovered from the dried fruit of Silybum marianum Gaertn. by separating the fatty oils therefrom, extracting the remaining solid residue with ethyl acetate, evaporating the ethyl acetate and dissolving the dry residue in a solvent mixture comprising methanol, water and petroleum ether to form a two-phase system wherein the chromanones are contained in the lower phase, recovering the polyhydroxyphenyl chromanones from the lower phase after subjecting same to multiple counter-current contact with petroleum ether.
Therapeutic FunctionHepatoprotectant
General DescriptionSilibinin, a principal component of silymarin, is a flavonolignan and an orally active flavonoid. It is isolated from the seeds of milk thistle (Sylibum marianum L).
Biochem/physiol ActionsSilibinin functions as a hepatoprotectant in patients with acute and chronic liver injury. This flavonoid fights against various cancer cells including, prostate, skin, breast, colon, lung, bladder and hepatocellular carcinoma (HCC). Silibinin exhibits its efficacy as an anti-cancer agent by blocking the secretion of proangiogenic factors from tumor cells, and by hindering growth and inducing apoptotic death of endothelial cells. In addition, it also interrupts capillary tube formation on Matrigel. Silibinin might be a good candidate for chemoprevention of prostate cancer (PC). It might be used as a potential therapeutic regimen for the treatment of endometriosis in vitro and in vivo.
Silibinin Preparation Products And Raw materials
Raw materialsEthyl acetate
Tag:Silibinin(22888-70-6) Related Product Information
POWDERED MILK THISTLE EXTRACT (250 MG) Silymarin 50% Silymarin DAB10 Milkthistleextract/Silymarin,Milkthistleseedextract,powder=Silymarin/Silybin,Milkthistleseedextract,fluid=Silymarin/Silybin MILK THISTLE P. E. EX SEMEN CARDUI/ SILYMARIN ISOSILYBIN(P)(PLEASE CALL) SILYBIN-B COBALT(II) ACETYLACETONATE Cupric acetylacetonate Tris(2,4-pentanedionato)chroMiuM(III) AKOS NCG1-0054 DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) 2,4-PENTANEDIONE, SILVER DERIVATIVE SILYBIN A/B COBALT ETHYLENE DIAMINE CHLORIDE Ferric acetylacetonate CHLOROPHOSPHONAZO III SILIBININ-N-METHYLGLUCAMINE, 95% (HPLC)