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Sodium chloroacetate

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Products Intro: Product Name:Chloroacetic acid sodium salt
CAS:3926-62-3
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CAS:3926-62-3
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CAS:3926-62-3
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CAS:3926-62-3
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Products Intro: Product Name:Chloroacetic acid sodium salt
CAS:3926-62-3
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Sodium chloroacetate Basic information
description Stability and Reactivity: HUMAN USE AND EXPERIENCE Metabolism/Pharmacokinetics
Product Name:Sodium chloroacetate
Synonyms:Aceticacid,chloro-,sodiumsalt;chloro-aceticacisodiumsalt;chloroctansodny;dowdefoliant;Chloroacetic acid sodium salt,98%;Sodium chloroacetate, synthesis grade;Chloroacetic acid sodiuM salt, 98% 5GR;Monoclonal Anti-Actin, α-Smooth Muscle - FITC antibody produced in mouse
CAS:3926-62-3
MF:C2H2ClNaO2
MW:116.48
EINECS:223-498-3
Product Categories:
Mol File:3926-62-3.mol
Sodium chloroacetate Structure
Sodium chloroacetate Chemical Properties
Melting point 199 °C (dec.)(lit.)
Fp 270°C
storage temp. -20°C
solubility 820g/l
form Crystalline Powder
color White
PH4.5-9.0 (50g/l, H2O, 20℃)
Water Solubility 440 g/L (20 ºC)
Sensitive Hygroscopic
Merck 14,2112
BRN 3597157
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference3926-62-3(CAS DataBase Reference)
EPA Substance Registry SystemSodium chloroacetate (3926-62-3)
Safety Information
Hazard Codes T,N
Risk Statements 25-38-50-36
Safety Statements 22-37-45-61-26
RIDADR UN 2659 6.1/PG 3
WGK Germany 2
RTECS AG1400000
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29154000
ToxicityLD50 orally in Rabbit: 95 mg/kg LD50 dermal Rat > 2000 mg/kg
MSDS Information
ProviderLanguage
Chloroacetic acid sodium salt English
SigmaAldrich English
ACROS English
ALFA English
Sodium chloroacetate Usage And Synthesis
descriptionSodium chloroacetate is a white colored powdered solid. It is soluble in water. It may be toxic ingestion or inhalation. It is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.
Sodium chloroacetate Toxicity list
In one study systemic effects to Sprague-Dawley rats (M/F, numbers per group not indicated) given single doses of sodium chloroacetate at 94, 282, or 470 mg/kg bw demonstrated increased sodium concentration in urine, increased potassium concentration in plasma, and reduced glutathione level in the liver at the highest dose; 2/3 of males died within 24 hours of treatment in the middle and high dose groups.
Stability and Reactivity:Sodium chloroacetate is stable at normal temperatures and  pressures. Incompatible with oxidizing agents, reducing  agents.
HUMAN USE AND EXPERIENCEThere are a number of case studies of the parent compound,  monochloroacetic acid (MCA), involving corrosion of skin and  eyes and fatalities related to skin absorption of toxicologically  significant amounts of MCA and a health-based target  concentration of 0.1 mg/L was calculated for MCA in drinking  water although Health Canada and Environment Canada have  categorized MCA as not entering the environment at levels that  may be hazardous to human health. There are, however, no  similar data or epidemiological reports for sodium  chloroacetate.
Metabolism/PharmacokineticsAfter absorption, monochloroacetic acid (parent compound  CAS 79-11-8) is converted to thiodiacetic acid and glycolic acid  and is accumulated in the liver and kidneys of rats.Metabolism of sodium monochloroacetate is expected to have a  similar pharmacokinetic profile.
Chemical PropertiesSodium chloroacetate is a white crystalline powder. It is soluble in water. It may be toxic ingestion or inhalation.
Sodium chloroacetate is a reactive and toxic material, so it is hydrolyzed to glycolic acid nearly quantitatively at the end of the production cycle. Chloroacetic acid always contains traces of dichloroacetic acid, a toxic and unreactive material that appears on the California Prop.65 list.
UsesSodium chloroacetate is the sodium salt of chloroacetic acid. It is used to prepare weed killers, dyes, vitamins and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor. Sodium dihydroxyethyltallow glycinate is the condensation product of dihydroxyethyl tallow amine and sodiumchloroacetate.It is used as a thickeningagent and asurfactant.
UsesSodium chloroacetate is used to prepare dyes and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor.
General DescriptionChloroacetic acid sodium salt is a white colored powdered solid. Chloroacetic acid sodium salt is soluble in water.Chloroacetic acid sodium salt may be toxic ingestion or inhalation. Sodium chloroacetate is used as a contact herbicide and a component in other herbicides, an intermediate in the production of carboxymethyl-cellulose, and other synthetic organic chemicals.
Air & Water ReactionsChloroacetic acid sodium salt is soluble in water.
Reactivity ProfileSalts, basic, such as Chloroacetic acid sodium salt, are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Health HazardHighly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire HazardNon-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.
Biochem/physiol ActionsActin plays an important role in cell motility, structure and integrity. Smooth muscle actin-α (SMA)/ α2-smooth muscle actin (ACTA2) interacts with β-myosin heavy chain and helps in vascular smooth muscle cell contraction. The encoded protein modulates the expression of c-MET (tyrosine-protein kinase Met) and focal adhesion kinase (FAK) in human lung adenocarcinoma cells, which positively and selectively mediates tumor progression. Mutation in the gene expression leads to thoracic aortic aneurysms and dissections (TAAD).
Safety ProfilePoison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Cland NazO. Used as an herbicide
Tag:Sodium chloroacetate(3926-62-3) Related Product Information
(Z)-2-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)acetic acid alpha-Methylcinnamylaldehyde 3-Thiazolidineacetic acid, 5-[(2Z)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5E)- Epalrestat Impurity 4 ethyl 2-((E)-5-((E)-2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetate Epalrestat iMpurity 2-[(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid Epalrestat Glycine, N-(dithiocarboxy)- (6CI,7CI,8CI,9CI) (Z)-2-methyl-3-phenylacrylaldehyde (5-BENZYLIDENE-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)-ACETIC ACID (2,4-DIOXO-1,3-THIAZOLIDIN-3-YL)ACETIC ACID 3-Thiazolidineaceticacid, 4-oxo-2-thioxo-, ethyl ester (Z,Z)-5-(2-Methyl-3-phenyl-propenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic Acid 3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5E)- Sodium chloroacetate Chloroacetic acid Sodium acetate trihydrate