Azlocillin sodium synthesis

Yield:-

Reaction Conditions:

with sodium hydroxide in water; pH=7-7.6 at 5 - 8;Concentration;

Steps:

1 Preparation of azlocillin sodium lyophilized powder:
In step S1, the above-mentioned method is used to prepare azlocillin acid in water for injection,Ratio of parts by weight of azlocillin acid and water for injection is 1: 3.5,Cooling to 5 ~ 8 ;Step S2, adding sodium hydroxide solution,Adjusting the pH to 7.0-7.6;Step S3, the medicinal active carbon was added,Stirring for 20 to 30 minutes,And the medicinal active carbon was removed by filtering through a 0.8 μm microporous filter.Step S4, the filtrate was removed after medicinal activated carbon sterilized by filtrationGet sterilized filtrate;The sterilization filtration comprises two successive filtration,First filtered through a 0.45 [mu] m microporous membrane,And then filtered through a 0.22 μm microporous filter.In step S5,Freeze-drying the filtrate to obtain azlocillin freeze-dried powder injection.

References:

Nanjing Zhengliang Medical Technology Co., Ltd.;Zhao, Mingliang CN105753886, 2016, A Location in patent:Paragraph 0038; 0039; 0040; 0041; 0042; 0043

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