Benzenemethanol, 4-fluoro-, 1-formate synthesis
- Product Name:Benzenemethanol, 4-fluoro-, 1-formate
- CAS Number:1146963-53-2
- Molecular formula:C8H7FO2
- Molecular Weight:154.14
Yield:1146963-53-2 98%
Reaction Conditions:
with tribromomelamine in neat (no solvent) at 20; for 0.733333 h;Green chemistry;chemoselective reaction;
Steps:
Formylation of 4-tert-butylbenzyl alcohol
General procedure: To the stirred mixture of 4-tert-butyl benzyl alcohol (1 mmol, 0.164 g) and ethyl formate (2 mL), tribromo melamine (0.1 mmol) was added without additional solvents. The resulting mixture was stirred at room temperature for 30 min. The reaction was monitored by TLC. On completion of reaction, the product was extracted with CH2Cl2 (5 mL × 4). The organic layer was separated, dried over anhydrous Na2SO4 (1.5 g), and concentrated under reduced pressure. Finally, the organic solvents were evaporated, and 4-tert-butylbenzyl formate was obtained in 92% yield. The identity of the product was confirmedby comparing the physical and spectral data with those of the known compound.
References:
Hajjami, Maryam;Ghorbani-Choghamarani, Arash;Karamshahi, Zahra;Norouzi, Masoomeh [Cuihua Xuebao/Chinese Journal of Catalysis,2014,vol. 35,# 2,p. 260 - 263]
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