ChemicalBook CAS DataBase List Diethyl glutarate

Diethyl glutarate synthesis

12synthesis methods

Product Name:Diethyl glutarate
CAS Number:818-38-2
Molecular formula:C9H16O4
Molecular Weight:188.22

623-73-4
147 suppliers
$26.69/5g

140-88-5
511 suppliers
$12.00/100ml

818-38-2
190 suppliers
$34.00/25g

Yield:-

Reaction Conditions:

with p-cresol;tris(bipyridine)ruthenium(II) dichloride hexahydrate in dichloromethane at 25; for 12 h;Irradiation;

Steps:

14 Example 14
Add Hans ester Et-HE (0.8mmol) to the reaction tube equipped with a magnetic stir bar, Ru(bpy)3Cl2·6H2O (0.004 mmol) and p-cresol (0.08 mmol). Cover the reaction tube and change the nitrogen three times, Use a micro syringe to inject ethyl acrylate (0.4mmol), Ethyl diazoacetate (0.8 mmol) and anhydrous dichloromethane (2.0 mL, 0.2M). Then the reaction tube was placed about 15 cm away from the 50W blue light source for illumination and stirring. React at 25°C for 12 hours until the diazonium consumption is complete (monitored by thin layer chromatography). After the solvent was removed by rotary evaporation under reduced pressure, a crude product was obtained. The crude product was purified by silica gel column chromatography to obtain the corresponding product (petroleum ether: ethyl acetate=25:1), the total yield: 73%.

References:

Sun Yat-sen University;Hu Wenhao;Liu Gengxin;Liu Junwen;Qiu Huang CN111362795, 2020, A Location in patent:Paragraph 0129-0132

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110-94-1 Synthesis