| Identification | More | [Name]
Ethyl N-(diphenylmethylene)glycinate | [CAS]
69555-14-2 | [Synonyms]
AURORA KA-6707
DIPHENYLMETHYLENE-GLYCINE ETHYL ESTER
ETHYL (DIPHENYLMETHYLENAMINO)ACETATE
ETHYL N-(DIPHENYLMETHYLENE)GLYCINATE
ETHYL (N-DIPHENYMETHYLENE)GLYCINATE
N-(DIPHENYLMETHYLENE)GLYCINE ETHYL ESTER
(N,N-DIPHENYLMETHYLENE)GLYCINE ETHYL ESTER
Ethyl N-benzhydrylideneglycinate
N-(DIPHENYLMETHYLENE)GLYCINE ETHYL ESTER ,98%
N-(DIPHENYLMETHYLENE)GLYCINE ETHYL ESTE&
Ethyl N-(diphenylmethylene)glyciate
N-(DIPHENYLMETHYLENE)GLYCINE ETHER ESTER
ETHYL2-(DIPHENYLMETHYLENEAMINO)ACETATE
Ethyl (diphenylmethyleneamino)acetate
[(Diphenylmethylene)amino]acetic acid ethyl ester
Benzhydrylideneaminoacetic acid ethyl ester
N-(α-Phenylbenzylidene)glycine ethyl ester
N-Benzhydrylideneglycine ethyl | [EINECS(EC#)]
614-987-6 | [Molecular Formula]
C17H17NO2 | [MDL Number]
MFCD00010590 | [Molecular Weight]
267.32 | [MOL File]
69555-14-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystalline powder or | [Melting point ]
51-53 °C(lit.)
| [Boiling point ]
195°C/2mmHg(lit.) | [density ]
1.0690 (rough estimate) | [refractive index ]
1.5400 (estimate) | [Fp ]
>110°C | [storage temp. ]
2-8°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder or Crystals | [pka]
2.22±0.50(Predicted) | [color ]
White to light yellow | [Sensitive ]
Moisture Sensitive | [λmax]
247nm(Hexane)(lit.) | [Detection Methods]
HPLC | [BRN ]
1979922 | [Stability:]
Moisture Sensitive | [Major Application]
diagnostic assay manufacturing
hematology
histology | [InChI]
1S/C17H17NO2/c1-2-20-16(19)13-18-17(14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-12H,2,13H2,1H3 | [InChIKey]
QUGJYNGNUBHTNS-UHFFFAOYSA-N | [SMILES]
CCOC(=O)C\N=C(/c1ccccc1)c2ccccc2 | [LogP]
1.35-3.18 at 25℃ and pH0-14 | [Dissociation constant]
2.3 at 25℃ | [CAS DataBase Reference]
69555-14-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS08 | [Signal word ]
Danger | [Hazard statements ]
H350 | [Precautionary statements ]
P201-P202-P280-P308+P313-P405-P501 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36/37:Wear suitable protective clothing and gloves .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
3
| [F ]
10-21 | [REACH Registrations]
Inactive | [HS Code ]
29224999 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Carc. 1B |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystalline powder or | [Uses]
N-(Diphenylmethylene)glycine Ethyl Ester is used as a reagent in the synthesis of pyrazolopyrrolyl tetrahydropyran DPP-4 inhibitors. | [Application]
Ethyl N-(diphenylmethylene)glycinate features a diphenylmethylene group that enhances its reactivity and stability, making it particularly useful in organic synthesis and pharmaceutical development.
| [Reactions]
Ethyl N-(diphenylmethylene)glycinate undergoes monoalkylations, dialkylations and Michael additions to ethylenic and acetylenic acceptors under appropriate solid-liquid phase transfer catalysis conditions. Further transformations of the α-disubstituted ketimines lead to α-alkylated aspartic and glutamic acid derivatives.
| [Synthesis]
Ethyl N-(diphenylmethylene)glycinate is prepared by transimination of Benzophenone Imine with alkyl glycinate hydrochloride (room temperature/CH2Cl2). | [References]
[1] Patent: EP1422220, 2004, A1. Location in patent: Page 5
[2] Patent: CN104557684, 2017, B. Location in patent: Paragraph 0021-0026; 0027; 0028; 0029; 0030-0033
[3] Tetrahedron Letters, 2005, vol. 46, # 16, p. 2795 - 2797
[4] Patent: US2010/173777, 2010, A1. Location in patent: Page/Page column 23
[5] Patent: WO2016/27285, 2016, A2. Location in patent: Page/Page column 50; 51 |
|
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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