Edrophonium chloride

Edrophonium chloride Struktur
116-38-1
CAS-Nr.
116-38-1
Englisch Name:
Edrophonium chloride
Synonyma:
Enlon;antirex;tensilon;Reversol;Edrophonium;Tensilon Chloride;EDROPHONIUM CHLORIDE;Edrophonium Chloride RS;Edrophonium chloride CRS;Edrophonium Chloride (200 mg)
CBNumber:
CB1170926
Summenformel:
C10H16ClNO
Molgewicht:
201.69
MOL-Datei:
116-38-1.mol

Edrophonium chloride Eigenschaften

Schmelzpunkt:
162-163 °C (decomp)
Dichte
1.0787 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
Löslichkeit
Very soluble in water, freely soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
Aggregatzustand
A crystalline solid
InChIKey
BXKDSDJJOVIHMX-UHFFFAOYSA-N
CAS Datenbank
116-38-1(CAS DataBase Reference)

Sicherheit

WGK Germany  3
RTECS-Nr. BQ5870000
HS Code  2923900100
Toxizität mouse,LD50,intraperitoneal,30mg/kg (30mg/kg),Pharmaceutical Chemistry Journal Vol. 10, Pg. 327, 1976.

Edrophonium chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White or almost white, crystalline powder

Verwenden

Pharmacologically, edrophonium is also similar to neostigmine; however, it begins to act quicker and is shorter lasting.

Verwenden

A reversible Acetylcholinesterase inhibitor.

Definition

ChEBI: The chloride salt of edrophonium. A reversible inhibitor of cholinesterase with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes), it is used in myasthenia gravis both diagnostically and to distinguish between unde - or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other mari e animals.

Allgemeine Beschreibung

Edrophonium chloride,ethyl(m-hydroxyphenyl)dimethylammonium chloride(Tensilon), is a reversible anticholinesterase agent. It isbitter and very soluble in water and alcohol. Edrophoniumchloride injection has a pH of 5.2 to 5.5. On parenteral administration,edrophonium has a more rapid onset andshorter duration of action than neostigmine, pyridostigmine,or ambenonium. It is a specific anticurare agent andacts within 1 minute to alleviate overdose of d-tubocurarine,dimethyl d-tubocurarine, or gallamine triethiodide.

Clinical Use

Edrophonium Chloride is also used to terminate the action of any one ofthese drugs when the physician so desires. It is of no value,however, in terminating the action of the depolarizing (i.e.,noncompetitive) blocking agents, such as decamethoniumand succinylcholine. In addition to inhibiting AChE, edrophoniumchloride has a direct cholinomimetic effect onskeletal muscle, which is greater than that of most otheranticholinesterase drugs.

Synthese

Edrophonium, ethyl-(3-hydroxyphenyl)dimethylammonium chloride (13.2.13), is made by reacting 3-dimethylaminophenol with ethylbromide, which forms ethyl(3-hydroxyphenyl)dimethylammonium bromide (13.2.12), the bromine atom of which is replaced with a chlorine atom by reacting it with silver chloride, giving edrophonium (13.2.13) [45].

Synthesis_116-38-1

Edrophonium chloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Edrophonium chloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 117)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2931 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49390 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
sales@tnjchem.com China 34572 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29220 58
AFINE CHEMICALS LIMITED
0571-85134551
info@afinechem.com CHINA 15377 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com CHINA 52867 58
LEAP CHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 24738 58

116-38-1()Verwandte Suche:


  • ETHYL[M-HYDROXYPHENYL]-DIMETHYLAMMONIUM CHLORIDE
  • EDROPHONIUM CHLORIDE
  • N-Ethyl-3-hydroxy-N,N-diMethyl-benzenaMiniuM Chloride
  • Reversol
  • Tensilon Chloride
  • antirex
  • dimethylethyl(m-hydroxyphenyl)-ammoniuchloride
  • ethyl(m-hydroxyphenyl)dimethyl-ammoniuchloride
  • n-ethyl-3-hydroxy-n,n-dimethyl-benzenaminiuchloride
  • tensilon
  • ethyl(3-hydroxyphenyl)dimethylammonium chloride
  • N-ethyl-3-hydroxy-N,N-dimethylanilinium chloride
  • Edrophonium
  • Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride
  • Enlon
  • Dimethylethyl(m-hydroxyphenyl)ammonium chloride
  • Edrophonium Chloride (200 mg)
  • Edrophonium Chloride (1234001)
  • Edrophonium chloride USP/EP/BP
  • Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, chloride (1:1)
  • Edrophonium chloride CRS
  • Edrophonium Chloride RS
  • 116-38-1
  • C10H16NOCl
  • C10H11NOD5Cl
  • Acetycholinesterase inhibitor
  • A to C
  • Biochemicals and Reagents
  • BioChemical
  • Cholinesterase, acetyl
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors by Enzyme
  • Enzyme Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Copyright 2019 © ChemicalBook. All rights reserved