에스포로늄클로라이드
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에스포로늄클로라이드 속성
- 녹는점
- 162-163 °C (decomp)
- 밀도
- 1.0787 (rough estimate)
- 굴절률
- 1.6000 (estimate)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 물에 매우 잘 녹고, 에탄올(96%)에 잘 녹으며, 염화메틸렌에는 거의 녹지 않습니다.
- 물리적 상태
- 결정성 고체
- 색상
- White to light yellow
- InChIKey
- BXKDSDJJOVIHMX-UHFFFAOYSA-N
- CAS 데이터베이스
- 116-38-1(CAS DataBase Reference)
안전
WGK 독일 | 3 | ||
---|---|---|---|
RTECS 번호 | BQ5870000 | ||
HS 번호 | 2923900100 | ||
독성 | mouse,LD50,intraperitoneal,30mg/kg (30mg/kg),Pharmaceutical Chemistry Journal Vol. 10, Pg. 327, 1976. |
에스포로늄클로라이드 C화학적 특성, 용도, 생산
화학적 성질
White or almost white, crystalline powder용도
Pharmacologically, edrophonium is also similar to neostigmine; however, it begins to act quicker and is shorter lasting.용도
A reversible Acetylcholinesterase inhibitor.정의
ChEBI: The chloride salt of edrophonium. A reversible inhibitor of cholinesterase with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes), it is used in myasthenia gravis both diagnostically and to distinguish between unde - or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other mari e animals.일반 설명
Edrophonium chloride,ethyl(m-hydroxyphenyl)dimethylammonium chloride(Tensilon), is a reversible anticholinesterase agent. It isbitter and very soluble in water and alcohol. Edrophoniumchloride injection has a pH of 5.2 to 5.5. On parenteral administration,edrophonium has a more rapid onset andshorter duration of action than neostigmine, pyridostigmine,or ambenonium. It is a specific anticurare agent andacts within 1 minute to alleviate overdose of d-tubocurarine,dimethyl d-tubocurarine, or gallamine triethiodide.Clinical Use
Edrophonium Chloride is also used to terminate the action of any one ofthese drugs when the physician so desires. It is of no value,however, in terminating the action of the depolarizing (i.e.,noncompetitive) blocking agents, such as decamethoniumand succinylcholine. In addition to inhibiting AChE, edrophoniumchloride has a direct cholinomimetic effect onskeletal muscle, which is greater than that of most otheranticholinesterase drugs.Synthesis
Edrophonium, ethyl-(3-hydroxyphenyl)dimethylammonium chloride (13.2.13), is made by reacting 3-dimethylaminophenol with ethylbromide, which forms ethyl(3-hydroxyphenyl)dimethylammonium bromide (13.2.12), the bromine atom of which is replaced with a chlorine atom by reacting it with silver chloride, giving edrophonium (13.2.13) [45].에스포로늄클로라이드 준비 용품 및 원자재
원자재
준비 용품
에스포로늄클로라이드 공급 업체
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