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Clotrimazol Produkt Beschreibung

Clotrimazole Struktur
23593-75-1
CAS-Nr.
23593-75-1
Bezeichnung:
Clotrimazol
Englisch Name:
Clotrimazole
Synonyma:
CLT;b5097;myclo;fb5097;bay5097;Empecid;FB 5097;Mycelax;Mycelex;Canifug
CBNumber:
CB7404063
Summenformel:
C22H17ClN2
Molgewicht:
344.84
MOL-Datei:
23593-75-1.mol

Clotrimazol Eigenschaften

Schmelzpunkt:
147-149°C
Siedepunkt:
501.14°C (rough estimate)
Dichte
1.1095 (rough estimate)
Brechungsindex
1.5940 (estimate)
storage temp. 
Store at RT.
Löslichkeit
Soluble in chloroform, DMSO, DMF and alcohols
pka
pKa 4.7(EtOH 50%aq ) (Uncertain)
Aggregatzustand
neat
maximale Wellenlänge (λmax)
556nm(Phosphate buffer sol.)(lit.)
Merck 
14,2417
InChIKey
VNFPBHJOKIVQEB-UHFFFAOYSA-N
NIST chemische Informationen
Clotrimazole(23593-75-1)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22-36/38
S-Sätze: 26-36
WGK Germany  3
RTECS-Nr. NI4377000
HS Code  29332900
Giftige Stoffe Daten 23593-75-1(Hazardous Substances Data)
Toxizität LD50 in male mice, rats (mg/kg): 923, 708 orally (Tettenborn)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301 BEI VERSCHLUCKEN
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Clotrimazol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/38:Reizt die Augen und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White or pale yellow, crystalline powder.

Verwenden

Clotrimazole is an antifungal agent.

Verwenden

An antifungal compound and CYP inhibitor

Indications

Clotrimazole (Lotrimin, Gyne-Lotrimin, Mycelex) is a broad-spectrum fungistatic imidazole drug used in the topical treatment of oral, skin, and vaginal infections with C. albicans. It is also employed in the treatment of infections with cutaneous dermatophytes.
Topical use results in therapeutic drug concentrations in the epidermis and mucous membranes; less than 10% of the drug is systemically absorbed. Although clotrimazole is generally well tolerated, local abdominal cramping, increased urination, and transient liver enzyme elevations have been reported.

Definition

ChEBI: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.

Trademarks

Gyne- Lotrimin (Schering-Plough); Gynix (Teva); Lotrimin (Schering-Plough); Mycelex (Bayer).

Clinical Use

1-(o-Chloro-α,α-diphenylbenzyl)imidazole (Lotrimin, Gyne-Lotrimin, Mycelex) is a broad-spectrum antifungal drug thatis used topically for the treatment of tinea infections and candidiasis.It occurs as a white crystalline solid that is sparinglysoluble in water but soluble in alcohol and most organic solvents.It is a weak base that can be solubilized by dilute mineralacids.
Clotrimazole is available as a solution in polyethyleneglycol 400, a lotion, and a cream in a concentration of 1%.These are all indicated for the treatment of tinea pedis, tineacruris, tinea capitis, tinea versicolor, or cutaneous candidiasis.A 1% vaginal cream and tablets of 100 mg and 500 mgare available for vulvovaginal candidiasis. Clotrimazole isextremely stable, with a shelf life of more than 5 years.

Veterinary Drugs and Treatments

Topical clotrimazole has activity against dermatophytes and yeasts; it may be useful for localized lesions associated with Malassezia. It is not very effective in treating dermatophytosis in cats.
Clotrimazole inhibits the biosynthesis of ergosterol, a component of fungal cell membranes leading to increased membrane permeability and probable disruption of membrane enzyme systems.

Clotrimazol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Clotrimazol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 368)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30002 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 493 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
Liaoning Benyuan Pharmaceutical Co., Ltd
024-45627555
024-45627566 sales@benyuanpharm.com China 62 50
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1861 55

23593-75-1(Clotrimazol)Verwandte Suche:


  • Clotrimazole in stock Factory
  • clotrimazole powder E:candyli(at)speedgainpharma(dot)com
  • 1-[(2-chlorophenyl)diph
  • 1-[(2-chlorophenyl)diphe
  • (2-Chlorophenyl)diphenyl-1-imidazolylmethane
  • (Chlorotrityl)imidazole
  • 1-((2-chlorophenyl)diphenylmethyl)-1h-imidazol
  • 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole
  • 1-(o-chloro-alpha,alpha-diphenylbenzyl)-imidazol
  • 1-[(2-chlorophenyl)diphenylmethyl]-1h-imidazol
  • 1-[alpha-(2-chlorophenyl)benzhydryl]imidazole
  • 1H-Imidazole, 1-[(2-chlorophenyl)diphenylmethyl]-
  • b5097
  • BAY 5097
  • Bay B 5097
  • Bay b 9057
  • bay5097
  • bayb5097
  • bay-b5097
  • bis-fenil-(2-clorofenil)-1-imidazolil-metano
  • Bis-phenyl-(2-chlorophenyl)-1-imidazoyl)methane
  • Bisphenyl-(2-chlorphenyl)-1-imidazolyl-methan
  • canestine
  • Chlotrimazole
  • clotrimazolecrystalline
  • component of Lotrimax
  • component of Lotrisone
  • component of Otomax
  • Empecid
  • FB 5097
  • fb5097
  • Gyne lotrimin
  • gyne-lotrimin
  • Imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-
  • Methane, bis-phenyl-(2-chlorophenyl)-1-imidazolyl-
  • Mono-baycuten
  • Mycelax
  • Mycelex
  • Mycelex G
  • mycelexg
  • mycelex-g
  • Mykosporin
  • Trimysten
  • Avermectin solution
  • Chromium Picolinate Premix
  • Metronidazole premix
  • Defatted soybean powder
  • SanHuangPowders
  • Horny proteas
  • Broad Bean Flower Tincture
  • 2,3-Diaminopyridine G imazalil
  • hemagglutinin
  • Badger seed oil
  • Dragon protein powder
  • Goat placenta freeze-dried powder
  • Hydrolyzed silkworm pupa protein powder
  • Medicinal white beeswax
  • Oyster Protein Peptide
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