클로트라이마졸
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클로트라이마졸 속성
- 녹는점
- 147-149°C
- 끓는 점
- 501.14°C (rough estimate)
- 밀도
- 1.1095 (rough estimate)
- 굴절률
- 1.5940 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름, DMSO, DMF 및 알코올에 용해됨
- 산도 계수 (pKa)
- pKa 4.7(EtOH 50%aq ) (Uncertain)
- 물리적 상태
- Solid
- 색상
- 흰색에서 거의 흰색
- 수용성
- <10mg/L(25℃)
- 최대 파장(λmax)
- 556nm(Phosphate buffer sol.)(lit.)
- Merck
- 14,2417
- InChI
- InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
- InChIKey
- VNFPBHJOKIVQEB-UHFFFAOYSA-N
- SMILES
- C1N(C(C2=CC=CC=C2Cl)(C2=CC=CC=C2)C2=CC=CC=C2)C=CN=1
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22-36/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 3 | ||
RTECS 번호 | NI4377000 | ||
HS 번호 | 29332900 | ||
유해 물질 데이터 | 23593-75-1(Hazardous Substances Data) | ||
독성 | LD50 in male mice, rats (mg/kg): 923, 708 orally (Tettenborn) |
클로트라이마졸 C화학적 특성, 용도, 생산
개요
Clotrimazole is an imidazole antifungal that is active against a wide variety of fungal forms and is effective in many types of fungal infections. It tightly binds sterol 14-화학적 성질
White or pale yellow, crystalline powder.용도
Clotrimazole is an antifungal agent.정의
ChEBI: A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group.Indications
Clotrimazole (Lotrimin, Gyne-Lotrimin, Mycelex) is a broad-spectrum fungistatic imidazole drug used in the topical treatment of oral, skin, and vaginal infections with C. albicans. It is also employed in the treatment of infections with cutaneous dermatophytes.Topical use results in therapeutic drug concentrations in the epidermis and mucous membranes; less than 10% of the drug is systemically absorbed. Although clotrimazole is generally well tolerated, local abdominal cramping, increased urination, and transient liver enzyme elevations have been reported.
일반 설명
Chemical structure: imidazoleClinical Use
1-(o-Chloro-α,α-diphenylbenzyl)imidazole (Lotrimin, Gyne-Lotrimin, Mycelex) is a broad-spectrum antifungal drug thatis used topically for the treatment of tinea infections and candidiasis.It occurs as a white crystalline solid that is sparinglysoluble in water but soluble in alcohol and most organic solvents.It is a weak base that can be solubilized by dilute mineralacids.Clotrimazole is available as a solution in polyethyleneglycol 400, a lotion, and a cream in a concentration of 1%.These are all indicated for the treatment of tinea pedis, tineacruris, tinea capitis, tinea versicolor, or cutaneous candidiasis.A 1% vaginal cream and tablets of 100 mg and 500 mgare available for vulvovaginal candidiasis. Clotrimazole isextremely stable, with a shelf life of more than 5 years.
클로트라이마졸 준비 용품 및 원자재
원자재
o-클로로벤조트리클로라이드
아세톤
톨루엔
염화알루미늄
이미다졸
2-클로로벤조익산
벤젠
염화 티오닐
염화 알루미늄
o-클로로톨루엔
석유 에테르
2-Chlorobenzoyl chloride
준비 용품
클로트라이마졸 공급 업체
글로벌( 897)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Wuhan wingroup Pharmaceutical Co., Ltd | +86-13296627870; +8613296627870 |
info@whwingroup.com | China | 703 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3878 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5987 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5882 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 |
admin@firsky-cn.com | China | 436 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2990 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10991 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
클로트라이마졸 관련 검색:
트리메틸페닐암모늄 클로라이드 메틸트리페닐포스포늄브로마이드 비페닐 1-메틸이미다졸 이미다졸
N-(Trimethylsilyl)imidazole
Chlorodimethylphenylsilane
2-Chlorotrityl chloride
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
CORONENE (D12)
Clotrimazole for peak identification
Clotrimazole impurity E
CLOTRIMAZOLE-D5 (PHENYL-D5)
CLOTRIMAZOLE-D5
Clotrimazole
Clotrimazole micronized
clotrimazole-hydrocortisone
clotrimazole(micro) usp 24