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Benzoesure Produkt Beschreibung

CAS-Nr.65-85-0
Bezeichnung:Benzoesure
Englisch Name:Benzoic acid
Synonyma:Benzoesure;Benzolcarbonsäure
Phenylcarbonsäure
ha1;e210;210;KRT31;and he;KRTHA1;PUROX B;NA-9094;NSC 149;ai3-0310
CBNumber:CB8698780
Summenformel:C7H6O2
Molgewicht:122.12
MOL-Datei:65-85-0.mol
Benzoesure physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 121-125 °C(lit.)
Siedepunkt:: 249 °C(lit.)
Dichte: 1.08
Dampfdichte: 4.21 (vs air)
Dampfdruck: 10 mm Hg ( 132 °C)
Brechungsindex: 1.504
FEMA : 2131 | BENZOIC ACID
Flammpunkt:: 250 °F
storage temp. : Store at RT.
Löslichkeit: soluble, clear, colorless (95% ethanol, 1gm/3mL)
pka: 4.19(at 25℃)
Aggregatzustand: Solid
Farbe: White to yellow-beige to orange
PH: 2.5-3.5 (H2O, 20℃)(saturated solution)
Wasserlöslichkeit: Slightly soluble. 0.34 g/100 mL
Merck : 14,1091
BRN : 636131
Stabilität:: Stable. Combustible. Incompatible with strong bases, strong oxidizing agents, alkalies.
InChIKey: WPYMKLBDIGXBTP-UHFFFAOYSA-N
CAS Datenbank: 65-85-0(CAS DataBase Reference)
NIST chemische Informationen: Benzoic acid(65-85-0)
EPA chemische Informationen: Benzoic acid(65-85-0)
Sicherheit
Kennzeichnung gefährlicher: Xn,T,Xi
R-Sätze:: 22-36-42/43-36/37/38-40-63-43-23/24/25-45-41-37/38-20/21/22-48/23-38-67-37
S-Sätze:: 26-45-37/39-24-22-36/37-24/25-23-53-36-63-39
RIDADR : UN 3077 9/PG 3
WGK Germany : 1
RTECS-Nr.: DG0875000
F : 21
Selbstentzündungstemperatur: 570 °C
Hazard Note : Harmful
TSCA : Yes
HS Code : 2916 31 00
Giftige Stoffe Daten: 65-85-0(Hazardous Substances Data)
Toxizität: LD50 orally in Rabbit: 1700 mg/kg LD50 dermal Rabbit > 5000 mg/kg

Benzoesure Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Benzoic acid,C6H5COOH, also known as benzene carboxylic acid and phenyl formic acid,is a colorless, monoclinic crystalline solid that has a melting point of 122.4"C and sublimes readily at 100·C. It is an aromatic carboxylic acid that is slightly soluble in water and moderately soluble in alcohol and ether. It is used as a preservative and its derivatives are valuable in medicine, commerce, and industry.
Chemische Eigenschaften
Benzoic acid is a white crystalline or flaky solid with a faint, pleasant odor.
Chemische Eigenschaften
Benzoic acid occurs as feathery, light, white or colorless crystals or powder. It is essentially tasteless and odorless or with a slight characteristic odor suggestive of benzoin.
Verwenden
benzoic acid is a preservative primarily for use against molds and yeasts. Its performance is classified only as fair against bacteria. Benzoic acid is used in concentrations of 0.05 to 0.1 percent. Although it has a low sensitizing rate, it may cause an allergic reaction in persons sensitive to similar chemicals.
Verwenden
Benzoic Acid is a preservative that occurs naturally in some foods such as cranberries, prunes, and cinnamon. it is most often used in the form of sodium benzoate because of the low aqueous solubility of the free acid. sodium benzoate is 180 times as soluble in water at 25°c as benzoic acid. the salt in solution is converted to the acid which is the active form. the optimum ph range for microbial inhi- bition is ph 2.5–4.0. it is used in acid foods such as carbonated bev- erages, fruit juices, and pickles. it is also termed benzoate of soda.
Verwenden
keratolytic
Definition
ChEBI: A compound comprising a benzene ring core carrying a carboxylic acid substituent.
Vorbereitung Methode
Although benzoic acid occurs naturally, it is produced commercially by several synthetic methods. One process involves the continuous liquid-phase oxidation of toluene in the presence of a cobalt catalyst at 150–2008℃ and 0.5–5.0 MPa (5.0–50.0 atm) pressure to give a yield of approximately 90% benzoic acid.
Benzoic acid can also be produced commercially from benzotrichloride or phthalic anhydride. Benzotrichloride, produced by chlorination of toluene, is reacted with 1 mole of benzoic acid to yield 2 moles of benzoyl chloride. The benzoyl chloride is then converted to 2 moles of benzoic acid by hydrolysis. Yield is 75–80%.
In another commercial process, phthalic anhydride is converted to benzoic acid, in about an 85% yield, by hydrolysis in the presence of heat and chromium and disodium phthalates.
Crude benzoic acid is purified by sublimation or recrystallization.
Biotechnologische Produktion
Benzoic acid is exclusively chemically synthesized on an industrial scale. Toluene from petrochemical routes is oxidized in the presence of the catalyst potassium permanganate to benzoic acid . However, a recent study described for the first time a benzoic acid production process by fermentation using Streptomyces maritimus. The production of benzoic acid during cultivation on glucose, starch, and cellobiose has been investigated. The best results have been achieved with product concentrations of 460 mg.L-1 in 6 days using starch as substrate. Additionally, a genetically modified S. maritimus optimized for endo-glucanasesecretion has been tested on phosphoric acid swollen cellulose. A final product concentration of 125 mg.L-1 was observed after 4 days of cultivation.
ERSCHEINUNGSBILD
WEISSE KRISTALLE ODER PULVER.
PHYSIKALISCHE GEFAHREN
Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft möglich.
CHEMISCHE GEFAHREN
Schwache Säure in wässriger Lösung. Reagiert mit Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK: IIb (nicht festgelegt, aber Informationen vorhanden); (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation und durch Verschlucken.
INHALATIONSGEFAHREN
Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitsschädliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen, die Haut und die Atmungsorgane. Die Substanz kann bei Kontakt einen nicht-allergischen Hautausschlag verursachen.
LECKAGE
Verschüttetes Material in Kunstsstoffbehältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Gesichtsschutz benutzen. Persönliche Schutzausrüstung: Schutzkleidung. Reste mit viel Wasser wegspülen.
Allgemeine Beschreibung
Boric acid,H3B03, also known as boracic acid, orthoboric acid, and sassolite, is a white solid composed of triclinic crystals.It is a derivative of barium oxide and is soluble in water. A white crystalline solid. Slightly soluble in water. The primary hazard is the potential for environmental damage if released. Immediate steps should be taken to limit spread to the environment. Used to make other chemicals, as a food preservative, and for other uses.
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36:Reizt die Augen.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R43:Sensibilisierung durch Hautkontakt möglich.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R45:Kann Krebs erzeugen.
R41:Gefahr ernster Augenschäden.
R37/38:Reizt die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
Air & Water Reaktionen
Vapor from molten Benzoic acid may form explosive mixture with air. The finely powdered dry acid is a significant dust explosion hazard [Bretherick, 5th ed., 1995, p. 884]. In air very rapid combustion occurs [Wilson, L.Y. et al., J. Chem. Ed., 1985, 62(10), p. 902]. Slightly soluble in water.
Reaktivität anzeigen
At high temperature Benzoic acid can react with oxidizing reagents.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S24:Berührung mit der Haut vermeiden.
S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Hazard
Moderately toxic by ingestion. Use restricted to 0.1% in foods.
Health Hazard
Dust may be irritating to nose and eyes. At elevated temperatures, fumes may cause irritation of eyes, respiratory system, and skin.
Brandgefahr
Behavior in Fire: Vapor from molten Benzoic acid may form explosive mixture with air. Concentrated dust may form explosive mixture.
Aussehen Eigenschaften
C7H6O2. Farbloses, geruchloses Pulver oder Plättchen.
Pharmazeutische Anwendungen
Benzoic acid is widely used in cosmetics, foods, and pharmaceuticals, as an antimicrobial preservative. Greatest activity is seen at pH values between 2.5–4.5.
Benzoic acid also has a long history of use as an antifungal agent in topical therapeutic preparations such as Whitfield’s ointment (benzoic acid 6% and salicylic acid 3%).
Landwirtschaftliche Anwendung
Fungicide, Insecticide: Used in the manufacture of benzoates; plasticizers, benzoyl chloride, alkyd resins, in the manufacture of food preservatives, in use as a dye binder in calico printing; in curing of tobacco, flavors, perfumes, dentifrices, standard in analytical chemistry. Not currently registered for use in the U.S. Benzoic acid is currently used in about a dozen European countries.
Gefahren für Mensch und Umwelt
Gesundheitsschädlich beim Verschlucken. Reizt die Augen. Führt zu Magen-Darm-Störungen.
Nicht mit Fluor oder Sauerstoff in Berührung bringen.
LDLo (oral, Mensch): 500 mg/kg.
Handelsname
RETARDER BA®; MICROL® Preservative; TENN-PLAS®; RETARDEX®; SALVO LIQUID®; SALVO POWDER®; TULSA®
Schutzmaßnahmen und Verhaltensregeln
Geeignete Schutzhandschuhe als kurzzeitiger Staubschutz.
Verhalten im Gefahrfall
Trocken aufnehmen. Der Entsorgung zuführen. Nachreinigen.
Kohlendioxid, Wasser, Pulver.
Brennbar. Im Brandfall Entstehung gefährlicher Dämpfe möglich.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft.
Nach Verschlucken: Reichlich Wasser trinken lassen. Erbrechen auslösen. Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
Ersthelfer: siehe gesonderten Anschlag

Sachgerechte Entsorgung
Als feste Laborchemikalienabfälle.
Sicherheit(Safety)
Ingested benzoic acid is conjugated with glycine in the liver to yield hippuric acid, which is then excreted in the urine; care should be taken when administering benzoic acid to patients with chronic liver disease. Benzoic acid is a gastric irritant, and a mild irritant to the skin. It is also a mild irritant to the eyes and mucous membranes. Allergic reactions to benzoic acid have been reported, although a controlled study indicated that the incidence of urticaria in patients given benzoic acid is no greater than in those given a lactose placebo. It has been reported that asthmatics may become adversely affected by benzoic acid contained in some antiasthma drugs.
The WHO acceptable daily intake of benzoic acid and other benzoates, calculated as benzoic acid, has been set at up to 5 mg/kg body-weight. The minimum lethal human oral dose of benzoic acid is 500 mg/kg body-weight.
LD50 (cat, oral): 2 g/kg
LD50 (dog, oral): 2 g/kg
LD50 (mouse, IP): 1.46 g/kg
LD50 (mouse, oral): 1.94 g/kg
LD50 (rat, oral): 1.7 g/kg
mögliche Exposition
Benzoic acid is used in production of plasticizers, benzoyl chloride, sodium benzoate and alkyl resins; in the manufacture of benzoates; in the manufacture of food preservatives; as a dye binder in calico printing; in curing of tobacco, flavors, perfumes, dentifrices; standard in analytical chemistry; antifungal agent.
Erste Hilfe
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Lager
Aqueous solutions of benzoic acid may be sterilized by autoclaving or by filtration.
A 0.1% w/v aqueous solution of benzoic acid has been reported to be stable for at least 8 weeks when stored in polyvinyl chloride bottles, at room temperature.
When added to a suspension, benzoic acid dissociates, with the benzoate anion adsorbing onto the suspended drug particles. This adsorption alters the charge at the surface of the particles, which may in turn affect the physical stability of the suspension. The addition of sodium azide has been shown to increase the stability of benzoic acid in skin permeation experiments.
The bulk material should be stored in a well-closed container in a cool, dry place.
Versand/Shipping
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9—Miscellaneous hazardous material, Technical Name Required.
läuterung methode
For use as a volumetric standard, analytical reagent grade benzoic acid should be carefully fused to ca 130o (to dry it) in a platinum crucible, and then powdered in an agate mortar. Benzoic acid has been crystallised from boiling water (charcoal), aqueous acetic acid, glacial acetic acid, *C6H6, aqueous EtOH, pet ether (b 60-80o), and from EtOH solution by adding water. It is readily purified by fractional crystallisation from its melt and by sublimation in a vacuum at 80o. The S-benzylisothiuronium salt has m 167o (from EtOH/H2O). [Beilstein 9 IV 273.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, caustics, ammonia, amines, isocyanates. Dust forms an explosive mixture with air.
Inkompatibilitäten
Undergoes typical reactions of an organic acid, e.g. with alkalis or heavy metals. Preservative activity may be reduced by interaction with kaolin.
Waste disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Regulatory Status
GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, irrigation solutions, oral solutions, suspensions, syrups and tablets, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Benzoesure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Hippursure Cobaltdi(acetat) Naphthalin Arsen Benzylalkohol Zinkoxid Bleimonoxid Toluol Chlor Ameisensure Phthalsure alpha, alpha, alpha-Trichlortoluol Naphthensuren, Cobaltsalze Phthalsureanhydrid
Downstream Produkte
Ethyl-3,4-dihydroxybenzoat Dibenzoylperoxid Natriumbenzoat 3-Nitrobenzoesäure 4-tert-Butylphenol 2,5-Diphenyl-1,3,4-oxadiazol Nefopam Dinatrium-4,4'-bis[(4-ethoxyphenyl)azo]stilben-2,2'-disulfonat 3,5-Diaminobenzoesure 3-Hydroxybenzoesure Ammoniumbenzoat Isopentylbenzoat Mebenil 3,5-Dihydroxybenzoesure Methylbenzoat Gonadotropin, chorionisch Methylacrylat 4-Phenylspiro[furan-2(3H),1'(3'H)-isobenzofuran]-3,3'-dion Benzoylchlorid Benzylbenzoat Kaliumbenzoat
Benzoesure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 509)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.comsales1@qqpharm.com CHINA 137 55
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 300 58
Yancheng Green Chemicals Co.,Ltd
86-515-87883661
86-515-87883652sales@greenchem-china.com CHINA 350 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20786 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555jack.li@time-chemicals.com CHINA 1374 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32651 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684info@tnjchem.com China 1659 55
Chemson Industrial (Shanghai) Co., Ltd.
86-21-65208861-ext8007
86-21-65180813sales1@chemson.com.cn CHINA 121 58
 
65-85-0(Benzoesure)Verwandte Suche:
Natriumbenzoat trans-zimtsure ACETIC ACID AQUANTRAAL Hyaluronsure Methyl-4-hydroxybenzoat Phenylvalerat Gummi benzoin, Siam- 2,2-Dimethoxy-1,2-diphenylethan-1-on 4-Aminobenzoesure Benzoesure CARBOXYLIC ACID 4-Hydroxybenzoesure Zitronensure (±)-2-Hydroxy-1,2-diphenylethan-1-on 4-Nitrobenzoesäure Benzylbenzoat Anthranilic acid
uniseptbza FEMA 2131 CARBOXYBENZENE DRACYLIC ACID BENZENE CARBOXYLIC ACID Benzenemethonic acid benzeneformic acid 'LGC' (2405) 'LGC' (2606) 'LGC' (4003) METTLER TOLEDO CALIBRATION SUBSTANCE ME 18555 AKOS BBS-00003711 ACIDUM BENZOICUM VEVOVITALL(R) RARECHEM AL BO 0012 PUROX B oracylic acid PHENYLFORMIC ACID phenyl carboxylic acid BenzoicAcidGr BENZOIC ACID, REAG. BENZOIC ACID, PHARMA Benzoic acid, for analysis ACS, 99.6% Benzoic acid, for analysis, 99.5% BENZOIC ACID PRIMARY STANDARD BENZOIC ACID REAGENT (ACS) benzoic acid solution mettler toledotm calibration substance me 18555,benzoic acid BENZOICACID,CRYSTAL,REAGENT,ACS BENZOICACID,CRYSTAL,USP,EP,BP,JP BENZOICACID,REAGENTSPECIAL,ACS Benzoic acid 99.5+% BENZOIC ACID (RG) benzenecarbonic acid benzenemonocarbonic acid benzenemonocarboxylic acid BENZOICACIDANDITSCOMMONSALTS BENZOESAEURE TECHNISCH Benzoesure Benzoic acid, ACS, 99.5% min Benzoic Acid Zone Refined (number of passes:20) BENZOIC ACID CRYSTAL Benzoic acid, 99+% , typically 99.6% BENZOIC ACID extrapure AR Benzoic Acid, Crystal, Reagent Benzoic acid, 99%, extra pure Benzoic acid, 99.5%, for analysis Benzoic acid, 99.6%, for analysis ACS Benzoic acid, for analysis Benzoic acid, for analysis ACS NA-9094 BENZOIC ACID Benzoic Acid, Acs Min Benzoic Acid Zone Refined Benzoic acid in Petroleum ether Benzoic acid ,99% Benzoic acid, synthesis grade Benzoic acid, reagent grade, ACS
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