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Aluminiumhydroxid Produkt Beschreibung

Aluminum hydroxide Struktur
21645-51-2
CAS-Nr.
21645-51-2
Bezeichnung:
Aluminiumhydroxid
Englisch Name:
Aluminum hydroxide
Synonyma:
c33;c4d;h46;c31c;c31f;AHDG;p30bf;af260;alugel;alusal
CBNumber:
CB9243680
Summenformel:
AlH3O3
Molgewicht:
78
MOL-Datei:
21645-51-2.mol

Aluminiumhydroxid Eigenschaften

Schmelzpunkt:
300℃
Dichte
2.42 g/cm3 at 20 °C
Dampfdruck
<0.1 hPa (20 °C)
storage temp. 
Store at +5°C to +30°C.
Löslichkeit
0.0015g/l
Aggregatzustand
colloidal suspension
Farbe
White
Wichte
2.42
Geruch (Odor)
Odorless
Säure-Base-Indikators(pH-Indikatoren)
>7
PH
8-9 (100g/l, H2O, 20℃)(slurry)
Wasserlöslichkeit
insoluble
Merck 
14,342
Solubility Product Constant (Ksp)
pKsp: 32.89
Stabilität:
Stable. Incompatible with strong bases.
CAS Datenbank
21645-51-2(CAS DataBase Reference)
EPA chemische Informationen
Aluminum hydroxide (21645-51-2)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36
S-Sätze: 26-36
WGK Germany  -
RTECS-Nr. BD0940000
TSCA  Yes
HS Code  28183000
Giftige Stoffe Daten 21645-51-2(Hazardous Substances Data)
Toxizität TDLo oral in child: 79gm/kg/2Y-I
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Aluminiumhydroxid Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

GERUCHLOSER WEISSER FESTSTOFF IN VERSCHIEDENEN FORMEN.

ARBEITSPLATZGRENZWERTE

TLV nicht festgelegt (ACGIH 2005).
MAK: 1,5 mg/m?(Alveolengängige Fraktion); 4 mg/m?(Einatembare Fraktion) Schwangerschaft: Gruppe D (DFG 2006).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation.

INHALATIONSGEFAHREN

Verdampfen bei 20°C vernachlässigbar; eine belästigende Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.

LECKAGE

Verschüttetes Material in Behältern sammeln. Reste mit viel Wasser wegspülen.

R-Sätze Betriebsanweisung:

R36:Reizt die Augen.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

Aluminum hydroxide, Al(OH)3, also known as aluminum trihydroxide, aluminum trihydrate, aluminum hydrate, hydrated alumina, and hydrated aluminum oxide, is a white to whitish-yellow water-insoluble powder with a specific gravity of 2.42. Aluminum hydroxide is used as a baseforpigments, as a water repellent in textile coatings, and as an antacid in medicine. Aluminum hydroxide is soluble in hydrochloric or sulfuric acids or in sodiumhydroxide.

Chemische Eigenschaften

Aluminum hydroxide adjuvant is a white hydrogel that sediments slowly and forms a clear supernatant.

Verwenden

aluminum hydroxide is an inorganic compound used to make a product less transparent. It is also used by formulators as a humectant, and to soften, smooth, and protect the skin. In addition it helps control product viscosity. often found in facial masks and make-up preparations.

Verwenden

Mainly used as an Active medicament in an Antacid Formulations, also used in manufacturing of Lake Colors, Inks, glass, effluent treatment, and fire retardants.

Vorbereitung Methode

Aluminum hydroxide adjuvant is prepared by the precipitation of a soluble aluminum salt by an alkali hydroxide, or the precipitation of an alkali aluminate by acid.

Definition

aluminium hydroxide: A white crystalline compound, Al(OH)3; r.d. 2.42-2.52. The compound occurs naturally as the mineral gibbsite (monoclinic). In the laboratory it can be prepared by precipitation from solutions of aluminium salts. Such solutions contain the hexaquoaluminium( III) ion with six water molecules coordinated, [Al(H2O)6]3+. In neutral solution this ionizes:
[Al(H2O)6]3+→H+ + [Al(H2O)5OH]2+
The presence of a weak base such as S2- or CO32- (by bubbling hydrogen sulphide or carbon dioxide through the solution) causes further ionization with precipitation of aluminium hydroxide
[Al(H2O)6]3+(aq) → Al(H2O)3(OH)3(s) + 3H+(aq)
The substance contains coordinated water molecules and is more correctly termed hydrated aluminium hydroxide. In addition, the precipitate has water molecules trapped in it and has a characteristic gelatinous form. The substance is amphoteric. In strong bases the aluminate ion is produced by loss of a further proton:
Al(H2O)3(OH)3(s) + OH-(aq)
[Al(H2O)2(OH)4]-(aq) + H2O(l)
On heating, the hydroxide transforms to a mixed oxide hydroxide, AlO.OH (rhombic; r.d. 3.01). This substance occurs naturally as diaspore and boehmite. Above 450℃ it transforms to γ-alumina.
In practice various substances can be produced that are mixed crystalline forms of Al(OH)3, AlO.OH, and aluminium oxide (Al2O3) with water molecules. These are known as hydrated alumina. Heating the hydrated hydroxide causes loss of water, and produces various activated aluminas, which differ in porosity, number of remaining -OH groups, and particle size. These are used as catalysts (particularly for organic dehydration reactions), as catalyst supports, and in chromatography. Gelatinous freshly precipitated aluminium hydroxide was formerly widely used as a mordant for dyeing and calico printing because of its ability to form insoluble coloured lakes with vegetable dyes.

Trademarks

Amphojel (Wyeth-Ayerst); Dialume (Rhone-Poulenc Rorer).

Pharmazeutische Anwendungen

Aluminium hydroxide (Al(OH)3) has several medical applications. It is used as an antacid for treating heartburn as well as acid indigestion (reflux oesophagitis). It is also known to have healing properties of peptic ulcers. In patients suffering from kidney failure, who show elevated serum phosphate levels (hyperphosphataemia), Al(OH)3 is used as a phosphate binder.
Al(OH)3 is an amphoteric compound , which means it can react as a base or as an acid. In its application as an anti-acid, Al(OH)3 reacts with any excess stomach acid (mainly HCl) with the formation of AlCl3 and water .
Al(OH)3 + 3HCl → AlCl3 + 3H2O
Al(OH)3 is known to cause constipation, so formulations of anti-acids often include a combination with Mg2+ antacids. Usually, oral antifoaming agents, such as simethicone, are added in order to reduce bloating and discomfort/pain.

Pharmazeutische Anwendungen

Aluminum hydroxide adjuvant is used in parenteral human and veterinary vaccines.It activates Th2 immune responses, including IgG and IgE antibody responses. It is also used for the isolation of certain serum components such as blood clotting factors.

Sicherheitsprofil

Poison by intraperitoneal route. Human systemic effects by ingestion: fever, osteomalacia, and gastrointestinal effects. When coprecipitated with bismuth hydroxide and reduced by H2, it is violently flammable in air. Incompatible with chlorinated rubber.

Sicherheit(Safety)

Aluminum hydroxide adjuvant is intended for use in parenteral vaccines and is generally regarded as nontoxic. It may cause mild irritation, dryness, and dermatitis on skin contact. On eye contact, aluminum hydroxide adjuvant may also cause redness, conjunctivitis, and short-term mild irritation. Ingestion of large amounts may cause gastrointestinal irritation with nausea, vomiting, and constipation. Inhalation of the dried product may cause respiratory irritation and cough. Type I hypersensitivity reactions following parenteral administration have been reported.

Veterinary Drugs and Treatments

Orally administered aluminum hydroxide is used to reduce hyperphosphatemia in patients with renal failure.

Lager

Aluminum hydroxide adjuvant is stable for at least 2 years when stored at 4–308℃ in well-sealed inert containers. It must not be allowed to freeze as the hydrated colloid structure will be irreversibly damaged.

Inkompatibilitäten

When exposed to phosphate, carbonate, sulfate, or borate anions, the point of zero charge for aluminum hydroxide adjuvant decreases.

Regulatory Status

GRAS listed. Accepted for use in human and veterinary parenteral vaccines in Europe and the USA. The limits for use in human vaccines are 0.85 mg aluminum/dose (FDA) and 1.25 mg aluminum/ dose (WHO). There are no established limits for use in veterinary vaccines. Reported in the EPA TSCA Inventory.

Aluminiumhydroxid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Aluminiumhydroxid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 440)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hebei Runbin Biotechnology Co. LTD
13180553332 13180553332
2179877681@qq.com CHINA 1000 58
SINOPRO.CO.LTD
0082-42-721-7177
0082-42-3676760 michael@sinopro.co.kr South Korea 300 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Yancheng Green Chemicals Co.,Ltd
86-25-86655873
86-25-52279193 sales@greenchem-china.com CHINA 93 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Jinan Finer Chemical Co., Ltd
+8615508631887 +86-531-88989536
+86-531-88989539 sales@finerchem.com CHINA 1706 58

21645-51-2(Aluminiumhydroxid)Verwandte Suche:


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