1,6-Dichlor-1,6-didesoxy-β-D-fructofuranosyl-4-chlor-4-desoxy-α-D-galaktose Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Sucralose is the only non-caloric sweetener made from sugar. It is in fact the latest non nutritive sweetener to have been approved by US FDA and other regulatory bodies and have hit the markets .
Sucralose is derived from sugar through a multi-step patented manufacturing process that selectively substitutes three atoms of chlorine for three hydroxyl groups on the sugar molecule. This change produces a sweetener that has no calories, yet is 600 times sweeter than sucrose, making it roughly twice as sweet as saccharin and four times as sweet as aspartame.
Chemische Eigenschaften
Sucralose is a white to off-white colored, free-flowing, crystalline
powder.
History
In 1975, sucralose was discovered by scientists from Tate & Lyle, working with researchers Leslie Hough and Shashikant Phadnis at Queen Elizabeth College (now part of King's College London). While looking for ways to use sucrose as a chemical intermediate, mixing sulfuryl chloride with sugar, Phadnis was told to "test" a chlorinated sugar compound. According to an anecdotal account, Phadnis thought Hough asked him to "taste" it, so he did and found the compound to be exceptionally sweet.
Sucralose was first approved for use in Canada in 1991. Subsequent approvals came in Australia in 1993, in New Zealand in 1996, in the United States in 1998, and in the European Union in 2004. By 2008, it had been approved in over 80 countries, including Mexico, Brazil, China, India, and Japan. In 2006, the FDA amended the regulations for foods to include sucralose as a "non-nutritive sweetener" in food.
Verwenden
Sucralose (1,6-dichloro-1,6-dideoxy-p-fructofuranosyl-4-chloro-oc-
D-galactopyra- noside) is a nonnutritive sweetener based on sucrose. It
is selectively chlorinated and the glycoside link between the two rings
is resistant to hydrolysis by acid or enzymes, so it is not metabolized. It
has 400 to 800 times the sweetness of sucrose, is very soluble in water,
and is stable in heat. It can be used in food products that are baked or
fried.
Sucralose is produced by the selective chlorination of the sucrose molecule
using a patented process by Tate and LyIe that replaces the three
hydroxyl groups (OH) with three chlorine (Cl) atoms.
This modified sugar is minimally absorbed by the body and passes out
unchanged. It was approved for use in foods and beverages in 1999 in
the United States.
Definition
ChEBI: A disaccharide derivative consisting of 4-chloro-4-deoxy-alpha-D-galactopyranose and 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranose units linked by a glycosidic bond.
Vorbereitung Methode
Sucralose may be prepared by a variety of methods that involve the
selective substitution of three sucrose hydroxyl groups by chlorine.
Sucralose can also be synthesized by the reaction of sucrose (or an
acetate) with thionyl chloride.
Allgemeine Beschreibung
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Sucralose is a polar, chlorinated sugar synthesized from saccharose precursor. It is widely used as a sweetener in a number of food and beverage products.
Pharmazeutische Anwendungen
Sucralose is used as a sweetening agent in beverages, foods, and
pharmaceutical applications. It has a sweetening power approximately
300–1000 times that of sucrose and has no aftertaste. It has
no nutritional value, is noncariogenic, does not promote dental
caries, and produces no glycemic response.
Sicherheit(Safety)
Sucralose is generally regarded as a nontoxic and nonirritant
material and is approved, in a number of countries, for use in food
products. Following oral consumption, sucralose is mainly unabsorbed
and is excreted in the feces.
The WHO has set an acceptable daily intake for sucralose of up
to 15 mg/kg body-weight.
LD50 (mouse, oral): > 16 g/kg
LD50 (rat, oral): > 10 g/kg
Lager
Sucralose is a relatively stable material. In aqueous solution, at
highly acidic conditions (pH < 3), and at high temperatures
(≤35℃), it is hydrolyzed to a limited extent, producing 4-chloro-4-
deoxygalactose and 1,6-dichloro-1,6-dideoxyfructose. In food
products, sucralose remains stable throughout extended storage
periods, even at low pH. However, it is most stable at pH 5–6.
Sucralose should be stored in a well-closed container in a cool,
dry place, at a temperature not exceeding 21℃. Sucralose, when
heated at elevated temperatures, may break down with the release
of carbon dioxide, carbon monoxide, and minor amounts of
hydrogen chloride.
Regulatory Status
The FDA, in April 1998, approved sucralose for use as a tabletop
sweetener and as an additive in a variety of food products. In the
UK, sucralose was fully authorized for use in food products in
2005. It is also accepted for use in many other countries
worldwide. Included in the Canadian List of Acceptable Nonmedicinal
Ingredients.
1,6-Dichlor-1,6-didesoxy-β-D-fructofuranosyl-4-chlor-4-desoxy-α-D-galaktose Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
