4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid
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- CAS-Nr.
- 959-24-0
- Bezeichnung:
- 4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid
- Englisch Name:
- Sotalol hydrochloride
- Synonyma:
- DAROB;SOTALEX;SOTACOR;MJ-1999;BETAPACE;DL-MJ 1999;SOTALOL HCL;SOLATOL HCL;Betapace AF;meadjohnson1999
- CBNumber:
- CB9712098
- Summenformel:
- C12H21ClN2O3S
- Molgewicht:
- 308.82
- MOL-Datei:
- 959-24-0.mol
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4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid Eigenschaften
- Schmelzpunkt:
- 218-220°C
- storage temp.
- 2-8°C
- Löslichkeit
- H2O: 20 mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Wasserlöslichkeit
- Soluble in phosphate buffered saline, DMSO, ethanol, water, and methanol.
- CAS Datenbank
- 959-24-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36/37/38 |
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| S-Sätze: |
26-36 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
PB0826000 |
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| HS Code |
2935904000 |
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| Toxizität |
LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H303 |
May be harmfulif swallowed |
Acute toxicity,oral |
Category 5 |
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P312 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P405 |
Unter Verschluss aufbewahren. |
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4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC
50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent. It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM. Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES). Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Sotalol hydrochloride is used as a potent beta adrenergic antagonist, prolongs the action potential and increases the refractory period. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 μM.
Definition
ChEBI: A hydrochloride salt that is the monohydrochloride of sotalol. It has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. It
is used (usually as the hydrochloride salt) for the management of ventricular and supraventricular arrhythmias.
Biologische Aktivität
A relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity. Also available as part of the Mixed Adrenergic Tocriset™ .
4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 245)Lieferanten
959-24-0(4'-(1-Hydroxy-2-isopropylaminoethyl)methansulfonanilidhydrochlorid)Verwandte Suche:
- 4-(2-isopropylamino-1-hydroxyaethyl)methanesulfonailidhydrochlorid
- 4’-(1-hydroxy-2-(isopropylamino)ethyl)methanesulfonanilidemonohydrochloride
- 4’-(1-hydroxy-2-(isopropylamino)ethyl)-methanesulfonanilidmonohydrochlorid
- isopropylaminohydroxyethylmethanesulfonanilidehydrochloride
- meadjohnson1999
- n-isopropyl-beta-(4-methanesulfonamidophenyl)ethanolaminehydrochloride
- SOTACOR
- SOTALEX
- SOTALOL HCL
- (+/-)-SOTALOL HYDROCHLORIDE
- SOTALOL HYDROCHLORIDE
- MJ-1999
- N-[4-[1-HYDROXY-2-[(1-METHYLETHYL)AMINO]ETHYL]PHENYL]METHANESULFONAMIDE HYDROCHLORIDE
- N-[4-(1-HYDROXY-2-[ISOPROPYLAMINO]ETHYL)-PHENYL]METHANESULFONAMIDE HYDROCHLORIDE
- D,L-Sotalol, Hydrochloride
- MJ-1999, Betapace, Darob, Sotacor, Sotalex
- 4'-[1-Hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide hydrochloride
- 4'-[2-(Isopropylamino)-1-hydroxyethyl]methanesulfonanilide monohydrochloride
- DL-MJ 1999
- Methanesulfonamide, N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-, monohydrochloride (9CI)
- N-Isopropyl-b-(4-methanesulfonamidophenyl)ethanolamine hydrochloride
- METHANESULPHONANILIDE41HYDROXY2ISOPROPYLAMINOETHYLMONOHYDROCHLORIDE
- 4'-(1-hydroxy-2-isopropylaminoethyl)methanesulphonanilide hydrochloride
- BETAPACE
- DAROB
- SOLATOL HCL
- (-N-[4-[1-Hydroxy-2-[(1-Methyl Ethyl) Amino]-ethyl]phenyl]methanesulfonamide
- SOTALOL HYDROCHLORIDE BP
- N-4-[1-Hydroxy-2-(isopropylamino)ethyl]methane sulfonanilide hydrochloride
- Beta-cardone hydrochloride
- Sotalol Hydrochloride (300 mg)
- Sotalol hydrochlorid
- Sotalol (Betapace)
- Sotalol hydrochloride COS
- Berlex Laboratories
- Betapace AF
- (±)-Sotalol hydrochloride,N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride
- MethanesulfonaMide,N-[4-[1-hydroxy-2-[(1-Methylethyl)aMino]ethyl]phenyl]-, hydrochloride (1:1)
- N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-methanesulfonamide,hydrochloride (1:1)
- Sotalol hydrochloride CRS
- N-[4-[(1RS)-1-Hydroxy-2-[(1-methylethyl)amino]ethyl]- phenyl]methanesulfonamide hydrochloride
- (+)-sotalol hydrochloride
- Sotalol hydrochloride USP/EP/BP
- Sotalol HCl (MJ 1999)
- Sotalol HydrochlorideQ: What is
Sotalol Hydrochloride Q: What is the CAS Number of
Sotalol Hydrochloride Q: What is the storage condition of
Sotalol Hydrochloride Q: What are the applications of
Sotalol Hydrochloride
- Sotalol Hydrochloride (1617408)
- 959-24-0
- C21H21ClN2O3S
- C12H20N2O3SxHCl
- C12H20N2O3SClH
- C12H21ClN2O3S
- C12H20N2O3SHCl
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