Prinomastat
- CAS No.
- 192329-42-3
- Chemical Name:
- Prinomastat
- Synonyms
- Ag3340;Ag 3340;Ag-3340;KB-R 9896;Prinomastat;AG3340 hydrochloride;AG 3340 hydrochloride;AG-3340 hydrochloride;Phenprobamate Impurity 2;Prinomastat hydrochloride
- CBNumber:
- CB01475597
- Molecular Formula:
- C18H21N3O5S2
- Molecular Weight:
- 423.51
- MDL Number:
- MFCD08690607
- MOL File:
- 192329-42-3.mol
- MSDS File:
- SDS
| Melting point | 149.8° |
|---|---|
| Density | 1.377±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | H2O: soluble15mg/mL (clear solution) |
| form | powder |
| pka | 9.25±0.23(Predicted) |
| color | white to beige |
| NCI Dictionary of Cancer Terms | AG3340; prinomastat |
| FDA UNII | 10T6626FRK |
| NCI Drug Dictionary | prinomastat |
Prinomastat price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0198 | Prinomastat hydrochloride ≥95% (HPLC) | 192329-42-3 | 5mg | $127 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0198 | Prinomastat hydrochloride ≥95% (HPLC) | 192329-42-3 | 25mg | $505 | 2024-03-01 | Buy |
| TRC | P715005 | Prinomastat | 192329-42-3 | 50mg | $760 | 2021-12-16 | Buy |
| ChemScene | CS-7961 | Prinomastat 95.03% | 192329-42-3 | 10mg | $655 | 2021-12-16 | Buy |
| ChemScene | CS-7961 | Prinomastat 95.03% | 192329-42-3 | 5mg | $375 | 2021-12-16 | Buy |
Prinomastat Chemical Properties,Uses,Production
Uses
Antineoplastic; antiangiogenic; treatment for retinal and subfoveal choroidal neovascularization (matrix metalloproteinase inhibitor).
Uses
Treatment of HaCaT-ras A-5RT3 tumor xenografts with Prinomastat (Ag3340) for 6 days strongly reduces tumor invasion and vascularization. Prinomastat is also a broad spectrum MMP inhibitor
Uses
Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samples and mouse embryo cultures. It may be used as a MMP-2 inhibitor in HepG2 cells.
Definition
ChEBI: Prinomastat is a hydroxamic acid that is (3S)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide in which the hydrogen attached to the thiomorpholine nitrogen has been replaced by a [4-(pyridin-4-yloxy)phenyl]sulfonyl group. It is a selective inhibitor with of matrix metalloproteinases (MMPs) 2, 3, 9, 13, and 14. It has a role as an antineoplastic agent, a matrix metalloproteinase inhibitor and an EC 3.4.24.35 (gelatinase B) inhibitor. It is a hydroxamic acid, a member of thiomorpholines, a sulfonamide, an aromatic ether and a member of pyridines. It is a conjugate base of a prinomastat(1+).
General Description
Prinomastat comprises hydroxamic acid group and chelates with zinc ion.
Biochem/physiol Actions
Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC50s, 30 pM & 50 pM, respectively.
Enzyme inhibitor
C113282), also known as AG3340, inhibits a number of matrix metalloproteinases, including collagenase-3 (Ki = 38 pM), gelatinase A (Ki = 83 pM), stromelysin 1 (Ki = 0.27 nM), and interstitial collagenase (Ki = 8.2 nM). Note that both the 3- and 4-pyridyl structures have been reported for prinomastat; however, the 4-analogue is the original structure reported for this inhibitor. Target(s): ADAM 17 endopeptidase, or tumor necrosis factor-a converting enzyme, or TACE; ADAMTS-4 endopeptidase, or aggrecanase; collagenase-3; gelatinase A; gelatinase B; interstitial collagenase; matrilysin; membrane-type matrix metalloproteinase-1, or matrix metalloproteinase 14; and stromelysin 1.
Prinomastat Preparation Products And Raw materials
Raw materials
Preparation Products
Prinomastat Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7887 | 56 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |