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Prinomastat

CAS No.
192329-42-3
Chemical Name:
Prinomastat
Synonyms
Ag3340;Ag 3340;Ag-3340;KB-R 9896;Prinomastat;AG3340 hydrochloride;AG 3340 hydrochloride;AG-3340 hydrochloride;Phenprobamate Impurity 2;Prinomastat hydrochloride
CBNumber:
CB01475597
Molecular Formula:
C18H21N3O5S2
Molecular Weight:
423.51
MDL Number:
MFCD08690607
MOL File:
192329-42-3.mol
MSDS File:
SDS
Last updated:2023-07-12 16:57:15

Prinomastat Properties

Melting point 149.8°
Density 1.377±0.06 g/cm3(Predicted)
storage temp. room temp
solubility H2O: soluble15mg/mL (clear solution)
form powder
pka 9.25±0.23(Predicted)
color white to beige
NCI Dictionary of Cancer Terms AG3340; prinomastat
FDA UNII 10T6626FRK
NCI Drug Dictionary prinomastat

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360
Precautionary statements  P201-P308+P313
Hazard Codes  T
Risk Statements  60-61
Safety Statements  53-45
WGK Germany  3
NFPA 704
0
2 0

Prinomastat price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0198 Prinomastat hydrochloride ≥95% (HPLC) 192329-42-3 5mg $127 2024-03-01 Buy
Sigma-Aldrich PZ0198 Prinomastat hydrochloride ≥95% (HPLC) 192329-42-3 25mg $505 2024-03-01 Buy
TRC P715005 Prinomastat 192329-42-3 50mg $760 2021-12-16 Buy
ChemScene CS-7961 Prinomastat 95.03% 192329-42-3 10mg $655 2021-12-16 Buy
ChemScene CS-7961 Prinomastat 95.03% 192329-42-3 5mg $375 2021-12-16 Buy
Product number Packaging Price Buy
PZ0198 5mg $127 Buy
PZ0198 25mg $505 Buy
P715005 50mg $760 Buy
CS-7961 10mg $655 Buy
CS-7961 5mg $375 Buy

Prinomastat Chemical Properties,Uses,Production

Uses

Antineoplastic; antiangiogenic; treatment for retinal and subfoveal choroidal neovascularization (matrix metalloproteinase inhibitor).

Uses

Treatment of HaCaT-ras A-5RT3 tumor xenografts with Prinomastat (Ag3340) for 6 days strongly reduces tumor invasion and vascularization. Prinomastat is also a broad spectrum MMP inhibitor

Uses

Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samples and mouse embryo cultures. It may be used as a MMP-2 inhibitor in HepG2 cells.

Definition

ChEBI: Prinomastat is a hydroxamic acid that is (3S)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide in which the hydrogen attached to the thiomorpholine nitrogen has been replaced by a [4-(pyridin-4-yloxy)phenyl]sulfonyl group. It is a selective inhibitor with of matrix metalloproteinases (MMPs) 2, 3, 9, 13, and 14. It has a role as an antineoplastic agent, a matrix metalloproteinase inhibitor and an EC 3.4.24.35 (gelatinase B) inhibitor. It is a hydroxamic acid, a member of thiomorpholines, a sulfonamide, an aromatic ether and a member of pyridines. It is a conjugate base of a prinomastat(1+).

General Description

Prinomastat comprises hydroxamic acid group and chelates with zinc ion.

Biochem/physiol Actions

Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC50s, 30 pM & 50 pM, respectively.

Enzyme inhibitor

C113282), also known as AG3340, inhibits a number of matrix metalloproteinases, including collagenase-3 (Ki = 38 pM), gelatinase A (Ki = 83 pM), stromelysin 1 (Ki = 0.27 nM), and interstitial collagenase (Ki = 8.2 nM). Note that both the 3- and 4-pyridyl structures have been reported for prinomastat; however, the 4-analogue is the original structure reported for this inhibitor. Target(s): ADAM 17 endopeptidase, or tumor necrosis factor-a converting enzyme, or TACE; ADAMTS-4 endopeptidase, or aggrecanase; collagenase-3; gelatinase A; gelatinase B; interstitial collagenase; matrilysin; membrane-type matrix metalloproteinase-1, or matrix metalloproteinase 14; and stromelysin 1.

Prinomastat Preparation Products And Raw materials

Raw materials

Preparation Products

Prinomastat Suppliers

Global( 25)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49392 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30250 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12338 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7887 56
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720 psaitong@jm-bio.com China 12308 58
Shanghai Han-Xiang Chemical Co., Ltd. 15971444841 amber@biochempartner.com China 3063 58
(S)-2,2-DIMETHYL-N-HYDROXY-4-[4-(4-PYRIDYLOXY)PHENYLSULFONYL]-1,4-THIAZINANE-3-CARBOXAMIDE 3-Thiomorpholinecarboxamide, N-hydroxy-2,2-dimethyl-4-((4-(4-pyridinyloxy)phenyl)sulfonyl)-, (S)- Ag 3340 Ag3340 Ag-3340 KB-R 9896 (S)-2,2-Dimethyl-4-((p-(4-pyridyloxy)phenyl)sulfonyl)-3-thiomorpholinecarbohydroxamic acid hydrochloride AG 3340 hydrochloride AG3340 hydrochloride 2-[(hydroxyamino)methyl]-5,6-dimethyl-4-(4-pyridin-4-yloxyphenyl)sulfonyl-morpholine-3-thione (S)-2-[(Hydroxyamino)methyl]-5,6-dimethyl-4-(4-pyridin-4-yloxyphenyl)sulfonylmorpholine-3-thione Prinomastat AG-3340 hydrochloride Prinomastat hydrochloride (3S)-N-hydroxy-2,2-dimethyl-4-[4-(pyridin-4-yloxy) benzenesulfonyl]thiomorpholine-3-carboxamide 3-Thiomorpholinecarboxamide, N-hydroxy-2,2-dimethyl-4-[[4-(4-pyridinyloxy)phenyl]sulfonyl]-, (3S)- Phenprobamate Impurity 2 (S)-N-Hydroxy-2,2-dimethyl-4-((4-(pyridin-4-yloxy)phenyl)sulfonyl)thiomorpholine-3-carboxamide 192329-42-3