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Pantoprazole Sodium

Pantoprazole Sodium
Pantoprazole Sodium structure
Chemical Name:
Pantoprazole Sodium
Zurcal;Nolpaza;PANTOZOL;PANTECTA;EUPANTOL;Pantoloc;Protonix;Controloc;midazolesodium;BY-1023 sodium
Molecular Formula:
Formula Weight:
MOL File:

Pantoprazole Sodium Properties

Melting point:
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
CAS DataBase Reference
138786-67-1(CAS DataBase Reference)
NCI Drug Dictionary
pantoprazole sodium
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  20/21/22-37/38-41-48
Safety Statements  22-26-36/37/39-45

Pantoprazole Sodium price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1604 Pantoprazole Sodium Pharmaceutical Secondary Standard; Certified Reference Material 138786-67-1 1 g $78.2 2021-03-22 Buy
Sigma-Aldrich 1494895 Pantoprazole sodium United States Pharmacopeia (USP) Reference Standard 138786-67-1 250 mg $366 2021-03-22 Buy

Pantoprazole Sodium Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid


Controloc,Byk Gulden ,Germany


An antiulcerative. Gastric pump inhibitor



Manufacturing Process

2-Chloromethyl-4,5-dimethoxy-3-methylpyridinium chloride (about 1.5 g) are added to a solution of 5-difluoromethoxy-1H-benzimidazole-2-thiol in 10 ml of ethanol and 10 ml of 1 N sodium hydroxide solution. The yellow reaction mixture is stirred at 20°C for 1 hour, a further 10 ml of water are added, whereupon a colorless solid precipitates out, the mixture is stirred for a further 5 hours and filtered and the residue is rinsed with 1 N sodium hydroxide solution and water and dried to constant weight. The 5difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole is obtained as an oil.
5-Difluoromethoxy-2-[(4,5-dimethoxy-2-pyridyl)methylthio]-1H-benzimidazole (about 1 g) are dissolved in 10 ml of dioxane and 2 ml of 1 N sodium hydroxide solution. An equimolar amount of a titrated aqueous sodium hypochlorite solution, to which 1 mole per liter of sodium hydroxide solution has been added, is first added dropwise, while cooling with ice. After one hour a further equivalent and after 3 hours half the equimolar amount of sodium hypochlorite are added, to achieve complete reaction. After a reaction time of 4 hours, 5 ml of 5% strength sodium thiosulfate solution and another 25 ml of dioxane are added and the upper dioxane phase is separated off, washed once with 5 ml of sodium thiosulfate solution and concentrated on a rotary evaporator. The oily residue is dissolved in 20 ml of water and 10 ml of ethyl acetate and the solution is brought to pH 7 with about 100 ml of a buffer solution of pH 6.8. The solid which has precipitated out is filtered off with suction over a suction filter, washed with water, extracted by stirring at 0C with acetone and dried. 5-Difluoromethoxy-2-[(4,5-dimethoxy-2pyridyl)methanesulfinyl]-1H-benzimidazole is prepared; yield about 85%.

brand name

Protonix (Wyeth).

Therapeutic Function


General Description

Pantoprazole sodium, racemicsodium5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sesquihydrate is a white tooff-white crystalline powder that is freely soluble in water,very slightly soluble in phosphate buffer at pH 7.4, and practicallyinsoluble in n-hexane. The benzimidazole of this drughas a weakly basic nitrogen (pyridine N, pKa 3.83) and an benzimidazoleproton (pKa 0.11), facilitating formulation as asodium salt. The stability of the compound in aqueous solutionis pH dependent; the rate of degradation increases with decreasingpH. At ambient temperature, the degradation half-lifeis approximately 2.8 hours at pH 5.0 and approximately 220hours at pH 7.8.
The absorption of pantoprazole is rapid (Cmax of2.5μg/mL, Tmax 2.5 hours) after single or multiple oral40-mg doses. Pantoprazole is well absorbed (77% bioavailability).Administration with food may delay its absorptionbut does not alter pantoprazole bioavailability. Pantoprazoleis distributed mainly in extracellular fluid. The serum proteinbinding of pantoprazole is about 98%, primarily to albumin.Pantoprazole is extensively metabolized in the liver throughthe CYP system, including O-demethylation (CYP2C19),with subsequent sulfation. Other metabolic pathways includesulfur oxidation by CYP3A4. There is no evidencethat any of the pantoprazole metabolites have significantpharmacological activity. Approximately 71% of a dose of pantoprazole is excreted in the urine, with 18% excretedin the feces through biliary excretion.

Pantoprazole Sodium Preparation Products And Raw materials

Raw materials

Preparation Products

Pantoprazole Sodium Suppliers

Global( 386)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-34979012 CHINA 739 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967 CHINA 1009 58
career henan chemical co
+86-371-86658258 CHINA 29954 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6369 58
18627774460 CHINA 743 58
BOC Sciences
1-631-614-7828 United States 19752 58
Shanghai Longyu Biotechnology Co., Ltd.
+86 15821988213 China 2471 58

View Lastest Price from Pantoprazole Sodium manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-26 Pantoprazole Sodium
US $460.00 / Kg/Bag 1KG 99% 1T Baoji Guokang Bio-Technology Co., Ltd.
2021-10-21 Pantoprazole sodium
US $1.00-500.00 / g 1g >99% 20tons Anhui Rencheng Technology Co., Ltd
2021-10-20 Pantoprazole Sodium
US $50.00-38.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

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