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beta-Alanine

Chemical Properties Description Uses Preparation
beta-Alanine
beta-Alanine structure
CAS No.
107-95-9
Chemical Name:
beta-Alanine
Synonyms
-Alaine;Analine;Abufene;BETA-ALA;NSC 7603;B-ALANINE;FEMA 3252;H-BAla-OH;á-alanine;SS-ALAINE
CBNumber:
CB0711205
Molecular Formula:
C3H7NO2
Formula Weight:
89.09
MOL File:
107-95-9.mol

beta-Alanine Properties

Melting point:
202 °C (dec.)(lit.)
Density 
1,437 g/cm3
refractive index 
1.4650 (estimate)
FEMA 
3252 | BETA-ALANINE
Flash point:
204-206°C
storage temp. 
Store at RT.
solubility 
H2O: 1 M at 20 °C, clear, colorless
pka
3.55(at 25℃)
form 
Crystalline Powder
color 
White
PH
6.0-7.5
Water Solubility 
Soluble in water(550g/L). Slightly soluble in alcohol. Insoluble in ether and acetone.
Decomposition 
204-206 ºC
λmax
λ: 260 nm Amax: ≤0.02
λ: 280 nm Amax: ≤0.02
JECFA Number
1418
Merck 
14,205
BRN 
906793
Stability:
Stable. Keep dry.
InChIKey
UCMIRNVEIXFBKS-UHFFFAOYSA-N
CAS DataBase Reference
107-95-9(CAS DataBase Reference)
NIST Chemistry Reference
Beta-alanine(107-95-9)
EPA Substance Registry System
.beta.-Alanine(107-95-9)

SAFETY

Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
RTECS  UA2369200
TSCA  Yes
HS Code  29224920

beta-Alanine price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 05159 β-Alanine BioUltra, ≥99.0% (NT) 107-95-9 100g $57.7 2018-11-13 Buy
Sigma-Aldrich 05159 β-Alanine BioUltra, ≥99.0% (NT) 107-95-9 500g $210 2018-11-13 Buy
TCI Chemical A0180 beta-Alanine >99.0%(T) 107-95-9 25g $14 2018-11-22 Buy
TCI Chemical A0180 beta-Alanine >99.0%(T) 107-95-9 500g $47 2018-11-22 Buy
Alfa Aesar A16665 beta-Alanine, 98% 107-95-9 250g $21.1 2018-11-13 Buy

beta-Alanine Chemical Properties,Uses,Production

Chemical Properties

White powder

Description

This is a secondary amino acid, which is formed in vivo by the degradation of dihydrouracil and carnosine. Because neuronal uptake and neuronal receptor sensitivity to β-alanine have been demonstrated, the compound may be a false transmitter replacing GABA. A rare genetic disorder, hyper-β-alaninemia, has been reported. It is used as a flavor enhancer, flavoring agent, nutrient supplement or adjuvant. β-Alanine has a slightly sweet taste.

Uses

It is widely used in medicine, feed, food, and other industries, mostly to synthesize pantothenic acid and calcium pantothenate (a medicine and feed additive), carnosine, pamidronate sodium, barley nitrogen. It is also used to produce plating corrosion inhibiter, as a biological reagent, and as an organic synthesis intermediate. Used as a food and health supplement additive. Endogenous beta-amino acids, non-selective glycine receptor agonists ,G-protein-coupled orphan receptor (TGR7, MrgD) ligand. Relying on the stability of marine biology, beta-aminopropionic acid has a protective effect on cells.

Preparation

  • Acrylonitrile and ammonia react in a solution of diphenylamine and t-butanol to create beta-aminopropionitrile, which is then alkalized to obtain beta-aminopropionic acid. In a dry autoclave, sequentially add acrylonitrile, diphenylamine and t- butanol, and stir for 5min. Then, add liquid ammonia, maintain the temperature at 100-109℃ and pressure at 1MPa, and stir for 4h. Cool to below 10℃ and stop mixing when the pressure reaches atmospheric pressure. At 65-70℃/(8.0-14.7kPa), decrease the pressure to recover t-butanol to obtain crude beta-aminopropionitrile. Distill the crude product under low pressure, collect the 66-105℃/(1.33-4.0kPa) distillation to obtain beta-aminopropionitrile, and maintain temperature for 1h. Steam under low pressure for half an hour to remove the ammonia in the reaction solution, add water, and drop in hydrochloric until PH reaches 7-7.2. Filter to remove trace impurities. Concentrate the filtered liquid until a large amount of solid precipitates, extract while hot and cool to below 10℃. Filter and vacuum dry to obtain beta-aminopropionic acid. This method requires 982kg beta-aminopropionitrile for every ton of product, and the yield of alkalization is 90%.
  • Place the alkaline sodium hypochlorite solution obtained from degradation of succinimide (Hoc reaction) (containing 14% sodium hypochlorite, 8% sodium hydroxide, 30% sodium carbonate) and ice into a reaction chamber, mix and add succinimide, and let react at 18-25℃ for 0.5h. Increase temperature to 40-50℃ and allow to react for 1h. Add hydrochloric acid to adjust the PH to 4-5, decrease the pressure to condense. After condensed and cooled, add 3 times the amount of 95% ethanol to allow inorganic salts to precipitate, filter, and repeat once again. Then, dilute the filtered liquid with 4 times the amount of distilled water and reflux for 1h. Add activated charcoal to remove color, filter, and pass the filtered liquid through exchange resin. Add activated charcoal to remove color, filter, decrease pressure to condense, cool to crystalize, filter, use distilled water to recrystallize once, and obtain beta-aminopropionic acid.
  • Hydrolyze and acidify beta-aminopropionitrile to obtain.

Description

β-Alanine (or beta-alanine) is a naturally occurring beta amino acid, which is an amino acid in which the amino group is at the β- position from the carboxylate group (i.e., two atoms away. The IUPAC name for β-alanine is 3-amino propanoic acid. Unlike its counterpart α-alanine, β-alanine has no stereocenter.
β-Alanine is not used in the biosynthesis of any major proteins or enzymes. It is formed in vivo by the degradation of dihydrouracil and carnosine. It is a component of the naturally occurring peptides carnosine and anserine and also of pantothenic acid (vitamin B5), which itself is a component of coenzyme A. Under normal conditions, β-alanine is metabolized into acetic acid.
β-Alanine is the rate-limiting precursor of carnosine, which is to say carnosine levels are limited by the amount of available β-alanine. Supplementation with β-alanine has been shown to increase the concentration of carnosine in muscles, decrease fatigue in athletes and increase total muscular work done.
Typically, studies have used supplementing strategies of multiple doses of 400 mg or 800 mg, administered at regular intervals for up to eight hours, over periods ranging from 4 to 10 weeks . After a 10 - week supplementing strategy, the reported increase in intramuscular carnosine content was an average of 80.1% (range 18 to 205%).

Chemical Properties

This is a secondary amino acid, which is formed in vivo by the degradation of dihydrouracil and carnosine. Because neuronal uptake and neuronal receptor sensitivity to β-alanine have been demonstrated, the compound may be a false transmitter replacing GABA. A rare genetic disorder, hyper-β-alaninemia, has been reported. It is used as a flavor enhancer, flavoring agent, nutrient supplement or adjuvant. β-Alanine has a slightly sweet taste.

Chemical Properties

White crystalline powder

Occurrence

Reported to occur as a component in amino acids; carnosine, anserine, pantothenic acid

Uses

β-Alanine is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of dihydrouracil (D449990) and carnosine. β-Alanine is also the rate-limiting precursor of carnosine, as a result supplementation with β-alanine increases the concentration of carnosine in muscles.

Definition

ChEBI: A naturally-occurring beta-amino acid comprising propionic acid with the amino group in the 3-position.

Preparation

By heating acrylic acid with concentrated aqueous ammonia under pressure, by addition of acrylonitrile to phthalimide or to ammonia; from β-aminopropionitrile, from succinimide by the Hofmann degradation.

Purification Methods

Crystallise β-alanine by dissolving it in a hot saturated aqueous solution, filtering, adding four volumes of absolute EtOH and cooling in an ice-bath. Recrystallise it in the same way and then finally, crystallise it from a warm saturated solution in 50% EtOH and adding four volumes of absolute EtOH with cooling in an ice-bath. The crystals are dried in a vacuum desiccator over P2O5. [Donovan & Kegeles J Am Chem Soc 83 255 1961, Beilstein 4 IV 2526.]

beta-Alanine Preparation Products And Raw materials

Raw materials

Preparation Products


beta-Alanine Suppliers

Global( 471)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21956 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1787 55
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 3911 58

View Lastest Price from beta-Alanine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-03 beta-Alanine in stock GMP Factory
107-95-9
US $1.00 / KG 1KG GMP Factory in China 1000 metric tons Chemwill Asia Co.,Ltd.
2018-07-30 beta-Alanine
107-95-9
US $480.00 / KG 10KG 95% 1000kg career henan chemical co

beta-Alanine Spectrum


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