1-(Boc-amino)cyclopropanecarboxylic acid
- CAS No.
- 88950-64-5
- Chemical Name:
- 1-(Boc-amino)cyclopropanecarboxylic acid
- Synonyms
- Boc-ACC-OH;BOC-AC3C-OH;BOC-ACPC-OH;BOC-1, 1-ACCP;Boc-1-aminocycL;BOC-(1)NH-DELTA-OH;BOC-(1)NHCPROPN-OH;RARECHEM AR PA 0007;1-{[(tert-butoxy)carbonyl]amino};Boc-1-aminocyclopropyl formic acid
- CBNumber:
- CB0409746
- Molecular Formula:
- C9H15NO4
- Molecular Weight:
- 201.22
- MDL Number:
- MFCD00083257
- MOL File:
- 88950-64-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-(Boc-amino)cyclopropanecarboxylic acid ≥98.0% (TLC) | 39977 | 1g | $572 |
| 1-[(tert-Butoxycarbonyl)amino]cyclopropanecarboxylic Acid min. 95.0 % | B3138 | 5G | $127 |
| 1-[(tert-Butoxycarbonyl)amino]cyclopropanecarboxylic Acid min. 95.0 % | B3138 | 25G | $380 |
| 1-(Boc-amino)cyclopropanecarboxylic acid | B619645 | 5G | $200 |
| Boc-1-aminocyclopropane-1-carboxylic acid | 266539 | 500mg | $333 |
| More product size | |||
| Melting point | 178 °C |
|---|---|
| Boiling point | 347.6±21.0 °C(Predicted) |
| Density | 1.21±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.04±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| BRN | 4430628 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C9H15NO4/c1-8(2,3)14-7(13)10-9(4-5-9)6(11)12/h4-5H2,1-3H3,(H,10,13)(H,11,12) |
| InChIKey | DSKCOVBHIFAJRI-UHFFFAOYSA-N |
| SMILES | C1(NC(OC(C)(C)C)=O)(C(O)=O)CC1 |
| CAS DataBase Reference | 88950-64-5(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P271-P280 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi,Xn,O | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
1-(Boc-amino)cyclopropanecarboxylic acid price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 39977 | 1-(Boc-amino)cyclopropanecarboxylic acid ≥98.0% (TLC) | 88950-64-5 | 1g | $572 | 2023-06-20 | Buy |
| TCI Chemical | B3138 | 1-[(tert-Butoxycarbonyl)amino]cyclopropanecarboxylic Acid min. 95.0 % | 88950-64-5 | 5G | $127 | 2026-03-19 | Buy |
| TCI Chemical | B3138 | 1-[(tert-Butoxycarbonyl)amino]cyclopropanecarboxylic Acid min. 95.0 % | 88950-64-5 | 25G | $380 | 2026-03-19 | Buy |
| TRC | B619645 | 1-(Boc-amino)cyclopropanecarboxylic acid | 88950-64-5 | 5G | $200 | 2021-12-16 | Buy |
| Usbiological | 266539 | Boc-1-aminocyclopropane-1-carboxylic acid | 88950-64-5 | 500mg | $333 | 2021-12-16 | Buy |
1-(Boc-amino)cyclopropanecarboxylic acid Chemical Properties,Uses,Production
Description
1-(Boc-amino)cyclopropanecarboxylic acid is an important organic compound. It is used in the biological field for the synthesis of irreversible inhibitors of tetrapeptide carboxypeptidases, leading to covalent substrate modifications; preparation of combinatorial libraries. It is used in the synthetic field as a pharmaceutical synthesis intermediate.
Chemical Properties
White crystalline powder
Uses
1-(Boc-amino)cyclopropanecarboxylic Acid is used as a reagent in the synthesis of pyrrolotriazinone derivatives as therapeutic PI3K inhibitors. Also used as a reagent in the synthesis of ether, carbamate and ester derivatives of adarotene as potential antitumor agents.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
68781-13-5
88950-64-5
General procedure for the synthesis of Boc-1-aminocyclopropanecarboxylic acid from di-tert-butyl dicarbonate and 1-aminocyclopropanecarboxylic acid hydrochloride: 4.18 g (30.37 mmol) of 1-aminocyclopropanecarboxylic acid hydrochloride was dissolved in 61 ml of dichloromethane and 4.7 ml (33.40 mmol) of triethylamine (TEA) was added. The mixture was stirred for 10 minutes and then the dichloromethane was removed by evaporation under reduced pressure. The reaction was dissolved in a solvent mixture of 36.5 ml of 1N NaOH solution and 101 ml of 1,4-dioxane, followed by the addition of 8.4 ml (36.44 mmol) of di-tert-butyl dicarbonate (Boc2O). The reaction mixture was stirred at room temperature for 16 h, after which the 1,4-dioxane was removed by evaporation under reduced pressure. The residue was acidified to pH 3 with 1N HCl and then extracted with 3100 ml of ethyl acetate. The organic phase was dried with anhydrous magnesium sulfate and after evaporation of the solvent under reduced pressure, 3.59 g of 1-(tert-butoxycarbonylamino)cyclopropylacetic acid was obtained in 59% yield. The product was characterized by 1H NMR (400 MHz, MeOD): δ 1.51 (s, 2H), 1.51 (s, 9H), 1.44 (s, 4H).
References
[1] Patent: EP2865664, 2015, A1. Location in patent: Paragraph 0088; 0089
[2] Tetrahedron, 2013, vol. 69, # 16, p. 3495 - 3505
1-(Boc-amino)cyclopropanecarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13815 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Klong Industrial Co., Ltd | 0086-519-68231162 | info@klongchem.com | CHINA | 131 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
View Lastest Price from 1-(Boc-amino)cyclopropanecarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-09-25 | 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
|
US $34.00-1.20 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-04-04 | 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
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2021-08-12 | 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
- US $34.00-1.20 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1-(Boc-amino)cyclopropanecarboxylic acid
88950-64-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
