Sertaconazole
- CAS No.
- 99592-32-2
- Chemical Name:
- Sertaconazole
- Synonyms
- SERTACONAZOLE;Sertaconazole nitrate;eno;(RS)-1-(2-((7-chloro-1-benzothiophen-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl) -1H-imidazole;Zalain;FI-7056;fi-7045;Dermofix;Enolase γ;Sertaconazol
- CBNumber:
- CB6701774
- Molecular Formula:
- C20H15Cl3N2OS
- Molecular Weight:
- 437.77
- MDL Number:
- MFCD00868881
- MOL File:
- 99592-32-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 146-147° |
|---|---|
| Boiling point | 614.1±55.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 6.68±0.12(Predicted) |
| color | White to Pale Yellow |
| InChI | InChI=1S/C20H15Cl3N2OS/c21-14-4-5-16(18(23)8-14)19(9-25-7-6-24-12-25)26-10-13-11-27-20-15(13)2-1-3-17(20)22/h1-8,11-12,19H,9-10H2 |
| InChIKey | JLGKQTAYUIMGRK-UHFFFAOYSA-N |
| SMILES | C1N(CC(OCC2=CSC3=C(Cl)C=CC=C32)C2=CC=C(Cl)C=C2Cl)C=CN=1 |
| CAS DataBase Reference | 99592-32-2(CAS DataBase Reference) |
| FDA UNII | 72W71I16EG |
| ATC code | D01AC14,G01AF19 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
Sertaconazole price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 561500 | eno PurifiedbyProteinGaffinitychromatography. | 50ug | $509 | 2026-06-03 | Buy | |
| Usbiological | 561500 | eno PurifiedbyProteinGaffinitychromatography. | 100ug | $708 | 2026-06-03 | Buy | |
| Biosynth | ZDA59232 | Sertaconazole nitrate | 99592-32-2 | 2.5g | $354 | 2026-06-05 | Buy |
| ChemScene | CS-0009631 | Sertaconazole | 99592-32-2 | 5mg | $70 | 2026-06-04 | Buy |
| ChemScene | CS-0009631 | Sertaconazole | 99592-32-2 | 10mg | $97 | 2026-06-04 | Buy |
Sertaconazole Chemical Properties, Uses, Production
Description
Sertaconazole has been developed and launched for the treatment of dermatological fungal infections by Ferrer Internacional S. A. Mylan received FDA approval for sertaconazole nitrate cream for the treatment of athlete's foot (tinea pedis) at the end of 2003.
Uses
An imidazole antifungal agent, inhibits the synthesis of ergosterol, an essential cell wall component of fungi.
Definition
ChEBI: 1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole is a member of the class of imidazoles that carries a 2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl group at position 1. It is a dichlorobenzene, an ether, a member of imidazoles and a member of 1-benzothiophenes.
Indications
Topical treatment of mycoses of the skin induced or sustained by fungi such as yeasts and dermatophytes. New formulations for the treatment of vaginal mycoses are in development.
Antimicrobial activity
Sertaconazole is a rather new broad-spectrum imidazole antimycotic with activity against almost all species of pathogenic fungi. It also has excellent activity against pathogenic yeasts.
Synthesis
2,4-Dichloro acetophenone 169 was brominated at low temperature to give bromide intermediate 170, which was used without isolation. To the same pot, five-fold excess of imidazole was added to give imidazolylacetophenone 171 in 71% yield from 169. Sodium borohydride was employed to reduce ketone 171 to alcohol 172 in 78% yield. Racemic alcohol 172 was resolved with (-)-DIP-chloride to give its corresponding chiral R-alcohol 173 in 80% yield. Compound 173 was then alkylated with 3-bromomethyl-7-chlorobenzo[b]thiophene (174) in dry DMF in the presence of potassium t-butoxide to give the alkylation product in 68% yield. Finally, 60% nitric acid was used to make sertaconazole mononitrate (XXI) in 89% yield.
Solubility in organics
Fairly soluble in ethanol (1.7 %), chloroform (1.5 %); slightly soluble in acetone (0.95 %); very slightly soluble in noctanol (0.069 %). Practically insoluble in water (< 0.01 %).
Sertaconazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Poseidon with Hainan Island Pharmaceutical Co., Ltd. | -- | China | 9 | 60 | |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11775 | 60 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6722 | 52 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Wuhan Fortuna Chemical Co., Ltd | 027-59207852 13308628970 | buy@fortunachem.com | China | 2665 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
Related articles
- Mechanism of action of Sertaconazole
- Sertaconazole contains a benzothiophene group that both augments its antifungal activity and confers a highly lipophilic fragm....
- Mar 30,2022
View Latest Price from Sertaconazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-16 | Sertaconazole nitrate
99592-32-2
|
1KG | 98.0% | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-20 | Sertaconazole nitrate USP/EP/BP
99592-32-2
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-07-27 | Sertaconazole
99592-32-2
|
$52.00-127.00 | 99.48% | 10g | TargetMol Chemicals Inc. |
-
- Sertaconazole nitrate
99592-32-2
- $0.00
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Sertaconazole nitrate USP/EP/BP
99592-32-2
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Sertaconazole
99592-32-2
- $52.00-127.00
- 99.48%
- TargetMol Chemicals Inc.
