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Zopiclone

Description References
Zopiclone
Zopiclone
CAS No.
43200-80-2
Chemical Name:
Zopiclone
Synonyms
Amoban;Imobam;Limovan;Sopivan;Amovane;Ximovan;imovane;Zimovane;Imovance;RP-27267
CBNumber:
CB1401303
Molecular Formula:
C17H17ClN6O3
Formula Weight:
388.81
MOL File:
43200-80-2.mol

Zopiclone Properties

Melting point:
1780C
Density 
1.1105 (estimate)
Flash point:
2℃
storage temp. 
Store at RT
solubility 
DMSO: 2 mg/mL
pka
pKa ﹣1.5±0.1(10% ACN in aq. H2SO4 t = 25.0) (Uncertain)
InChIKey
GBBSUAFBMRNDJC-UHFFFAOYSA-N
CAS DataBase Reference
43200-80-2(CAS DataBase Reference)
NIST Chemistry Reference
Zopiclone(43200-80-2)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi,F
Risk Statements  20/21/22-36/37/38-62-36-11
Safety Statements  26-36-36/37-16
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  TL1425000
HS Code  29339900
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Zopiclone price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Z-003 Zopiclone solution 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material 43200-80-2 003-1ml $79.3 2018-11-20 Buy
Sigma-Aldrich Z4900 Zopiclone 43200-80-2 10mg $740 2018-11-20 Buy
Cayman Chemical 14235 Zopiclone ≥98% 43200-80-2 5mg $211 2018-11-19 Buy
Cayman Chemical 14235 Zopiclone ≥98% 43200-80-2 1mg $65 2018-11-19 Buy
Sigma-Aldrich BP812 Zopiclone British Pharmacopoeia (BP) Reference Standard 43200-80-2 bp812 $179 2018-11-23 Buy

Zopiclone Chemical Properties,Uses,Production

Description

Zopiclone is an agonist at the type A γ-aminobutyric acid (GABA) receptor. It is a non-benzodiazepine hypnotic which was first reviewed in Drugs in 1986 and it is indicated for short-term treatment of insomnia. Zopiclone has a relatively low propensity to cause residual clinical effects (such as difficulty in waking or reduced morning concentration).

References

[1] Stuart Noble, Heather D. Langtry and Harriet M. Lamb, Drugs, 1998, vol. 55, 277-302
[2] G. Hajak, W. E. Müller, H. U. Wittchen, D. Pittrow, W. Kirch, Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data, Addiction, 2003, vol. 98, 1371-1378

Chemical Properties

Crystalline Solid

Uses

antihyperammonemic,antineoplastic

Uses

inhibits tyrosinase and prevents melanin formation used to whiten and lighten skin

Uses

Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic

Definition

ChEBI: A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position.

Zopiclone Preparation Products And Raw materials

Raw materials

Preparation Products


Zopiclone Suppliers

Global( 194)Suppliers
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Beijing Cooperate Pharmaceutical Co.,Ltd.
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Mainchem Co., Ltd.
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