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Zopiclone

Description References
Zopiclone
Zopiclone structure
CAS No.
43200-80-2
Chemical Name:
Zopiclone
Synonyms
Amoban;Imobam;Limovan;Sopivan;Amovane;Ximovan;imovane;CS-1331;Zimovane;Imovance
CBNumber:
CB1401303
Molecular Formula:
C17H17ClN6O3
Formula Weight:
388.81
MOL File:
43200-80-2.mol

Zopiclone Properties

Melting point:
1780C
Boiling point:
580.7±50.0 °C(Predicted)
Density 
1.1105 (estimate)
Flash point:
2℃
storage temp. 
Store at RT
solubility 
DMSO: 2 mg/mL
pka
pKa ﹣1.5±0.1(10% ACN in aq. H2SO4 t = 25.0) (Uncertain)
InChIKey
GBBSUAFBMRNDJC-UHFFFAOYSA-N
CAS DataBase Reference
43200-80-2(CAS DataBase Reference)
FDA UNII
03A5ORL08Q
NIST Chemistry Reference
Zopiclone(43200-80-2)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H312-H315-H332-H335-H361-H225-H302+H332-H319
Precautionary statements  P261-P280-P210-P305+P351+P338
Hazard Codes  Xn,Xi,F
Risk Statements  20/21/22-36/37/38-62-36-11
Safety Statements  26-36-36/37-16
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  TL1425000
HS Code  29339900

Zopiclone price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Z-003 Zopiclone solution 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material 43200-80-2 003-1ml $81 2019-12-02 Buy
Sigma-Aldrich Z4900 Zopiclone 43200-80-2 10mg $740 2019-12-02 Buy
Cayman Chemical 14235 Zopiclone ≥98% 43200-80-2 5mg $211 2020-06-24 Buy
Cayman Chemical 14235 Zopiclone ≥98% 43200-80-2 1mg $69 2020-06-24 Buy
Sigma-Aldrich BP812 Zopiclone British Pharmacopoeia (BP) Reference Standard 43200-80-2 bp812 $183 2019-12-02 Buy

Zopiclone Chemical Properties,Uses,Production

Description

Zopiclone is an agonist at the type A γ-aminobutyric acid (GABA) receptor. It is a non-benzodiazepine hypnotic which was first reviewed in Drugs in 1986 and it is indicated for short-term treatment of insomnia. Zopiclone has a relatively low propensity to cause residual clinical effects (such as difficulty in waking or reduced morning concentration).

References

[1] Stuart Noble, Heather D. Langtry and Harriet M. Lamb, Drugs, 1998, vol. 55, 277-302
[2] G. Hajak, W. E. Müller, H. U. Wittchen, D. Pittrow, W. Kirch, Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data, Addiction, 2003, vol. 98, 1371-1378

Description

Zopiclone is an effective hypnotic agent with a short duration of action. Although it interacts with the benzodiazepine receptor complex, it is reported to have minimal effects on memory, little synergy with alcohol, and low abuse potential.

Chemical Properties

Crystalline Solid

Originator

Rhone-Poulenc (France)

Uses

Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic

Uses

antihyperammonemic,antineoplastic

Uses

inhibits tyrosinase and prevents melanin formation used to whiten and lighten skin

Definition

ChEBI: A pyrrolo[3,4-b]pyrazine compound having a 4-methylpiperazine-1-carboxyl group at the 5-position, a 5-chloropyridin-2-yl group at the 6-position and an oxo-substituent at the 7-position.

brand name

IMOVANE

World Health Organization (WHO)

Zopiclone was introduced as a sedative in 1985. It remains registered in several countries and the World Health Organization is not aware of any other country that has refused registration.

Zopiclone Preparation Products And Raw materials

Raw materials

Preparation Products

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