Fmoc-8-amino-3,6-dioxaoctanoic acid
- CAS No.
- 166108-71-0
- Chemical Name:
- Fmoc-8-amino-3,6-dioxaoctanoic acid
- Synonyms
- FMOC-AEEA-OH;FMOC-AEEA;FMOC-AEEAC-OH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azadodecan-12-oic acid;FMoc-NH-PEG2-CH2COOH;FMOC-AEEAC;FMOC-8-AMINO-3,6-DIOXAOCTANOIC ACID;Fmoc-Ado-OH;N-formylglycine t-butylester;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID
- CBNumber:
- CB2169923
- Molecular Formula:
- C21H23NO6
- Molecular Weight:
- 385.41
- MDL Number:
- MFCD01321015
- MOL File:
- 166108-71-0.mol
- MSDS File:
- SDS
Melting point | 90-92℃ |
---|---|
Boiling point | 631.4±45.0 °C(Predicted) |
Density | 1.265±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,2-8°C |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
pka | 3.40±0.10(Predicted) |
form | Crystalline Powder |
color | White |
InChI | InChI=1S/C21H23NO6/c23-20(24)14-27-12-11-26-10-9-22-21(25)28-13-19-17-7-3-1-5-15(17)16-6-2-4-8-18(16)19/h1-8,19H,9-14H2,(H,22,25)(H,23,24) |
InChIKey | XQPYRJIMPDBGRW-UHFFFAOYSA-N |
SMILES | C(O)(=O)COCCOCCNC(=O)OCC1C2=C(C=CC=C2)C2=C1C=CC=C2 |
CAS DataBase Reference | 166108-71-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P271-P261-P280 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 29189900 | |||||||||
NFPA 704 |
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Fmoc-8-amino-3,6-dioxaoctanoic acid price More Price(63)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 95003 | {2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid ≥95.0% (HPLC) | 166108-71-0 | 500mg | $234 | 2024-03-01 | Buy |
Sigma-Aldrich | 8.51037 | Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem? | 166108-71-0 | 1g | $453 | 2024-03-01 | Buy |
TCI Chemical | F0719 | 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid >97.0%(HPLC) | 166108-71-0 | 1g | $265 | 2024-03-01 | Buy |
TCI Chemical | F0719 | 8-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3,6-dioxa-n-octanoic Acid >97.0%(HPLC) | 166108-71-0 | 200mg | $89 | 2024-03-01 | Buy |
Alfa Aesar | H63641 | (2-[2-(Fmoc-amino)ethoxy]ethoxy)acetic acid, 95% | 166108-71-0 | 250mg | $114 | 2024-03-01 | Buy |
Fmoc-8-amino-3,6-dioxaoctanoic acid Chemical Properties,Uses,Production
Uses
[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid is a hydrophilic, heterobifunctional spacer.
Description
Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical Properties
White solid
Uses
8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.
Uses
Hydrophillic spacer group.
Application
Fmoc-8-amino-3,6-dioxaoctanoic acid is a cleavable ADC linker for the synthesis of antibody-drug couplings (ADCs). It is also a PEG linker for the synthesis of PROTAC. It is widely used in drug delivery systems as it is mainly used to enhance the solubility or targeting of drugs and improve their bioavailability.
Fmoc-8-amino-3,6-dioxaoctanoic acid Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shandong Hengshannuode Pharmaceutical Technology Co., Ltd. | +8615065888978 | admin@hsnordpharma.com | China | 92 | 58 |
XIAMEN SINOPEG BIOTECH CO., LTD. | +86-0592-7761068 +8617350879715 | changaiwei@sinopeg.com | China | 59 | 58 |
Ningxia LabsChem Co., Ltd. | 0952-9294929 +8613895679378 | 48472788@qq.com | China | 352 | 58 |
Sichuan HongRi Pharma-Tech Co.,Ltd | +86-028-64841719 +8618980456393 | daisy@enlaibio.com | China | 1369 | 58 |
Suzhou Chukai Pharma Tech Co.,Ltd | +8615062531973 | 2279973922@qq.com | China | 224 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 | sales@alphabiopharm.com | China | 886 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
View Lastest Price from Fmoc-8-amino-3,6-dioxaoctanoic acid manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-28 | Fmoc-AEEA-OH
166108-71-0
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 98%;99% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
2024-03-28 | Fmoc-8-amino-3,6-dioxaoctanoic acid
166108-71-0
|
US $0.00 / KG | 25KG | 98% | Inquiry | PNP Biotech Co. Ltd | ||
2024-01-02 | [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid
166108-71-0
|
US $60.00-600.00 / KG | 1KG | 0.99 | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd |
- Fmoc-AEEA-OH
166108-71-0
- US $0.00-0.00 / kg
- 98%;99%
- Sichuan HongRi Pharma-Tech Co.,Ltd
- Fmoc-8-amino-3,6-dioxaoctanoic acid
166108-71-0
- US $0.00 / KG
- 98%
- PNP Biotech Co. Ltd
- [2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid
166108-71-0
- US $60.00-600.00 / KG
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
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