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Pefloxacin

Pefloxacin
Pefloxacin structure
CAS No.
70458-92-3
Chemical Name:
Pefloxacin
Synonyms
am725;1584rb;am-725;1589RB;RB-1589;EU-5306;Penaeine;peflacin;PEFLOXACIN;Penoxacine
CBNumber:
CB2304155
Molecular Formula:
C17H20FN3O3
Formula Weight:
333.36
MOL File:
70458-92-3.mol

Pefloxacin Properties

Melting point:
270-272° (dec)
Boiling point:
529.1±50.0 °C(Predicted)
Density 
1.320±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
pka
0.16±0.20(Predicted)
CAS DataBase Reference
70458-92-3(CAS DataBase Reference)
FDA UNII
2H52Z9F2Q5
ATC code
J01MA03
SAFETY
  • Risk and Safety Statements
Toxicity LD50 in mice (mg/kg): 225 i.v., 1000 orally; in rats (g/kg): 1.5 i.p., 2.5 orally (Goueffon)

Pefloxacin price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P0106 Pefloxacin mesylate dihydrate 70458-92-3 10 g $60.4 2021-12-16 Buy
Usbiological 241178 Pefloxacin 70458-92-3 1g $156 2021-12-16 Buy
Usbiological 462119 Pefloxacin Mesylate Dihydrate 70458-92-3 5g $305 2021-12-16 Buy
Usbiological 287889 Pefloxacin 70458-92-3 25g $398 2021-12-16 Buy
TRC P218350 Pefloxacinium 70458-92-3 1g $670 2021-12-16 Buy

Pefloxacin Chemical Properties,Uses,Production

Uses

antibacterial;DNA gyrase inhibitor

Definition

ChEBI: A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.

Pharmaceutical Applications

A 6-fluoro, 7-piperazinyl quinoline available for oral and intravenous administration. The in-vitro activity is very similar to that of norfloxacin . It is active against H. ducreyi, V. cholerae and Legionella spp., but Campylobacter and Acinetobacter spp. and pseudomonads are not susceptible. It has poor activity against pneumococci, chlamydiae, mycoplasmas and ureaplasmas. L. monocytogenes, Nocardia spp. and anaerobes are resistant.
A plasma concentration of c. 5 mg/L is achieved 1–1.5 h after a 400 mg oral dose. The plasma elimination half-life is 8.5–15 h. It is widely distributed, concentrations in bone, brain, blister fluid, CSF, saliva, sputum and prostate all approximating, and in some cases exceeding, the simultaneous plasma concentration. It is extensively metabolized to the desmethyl (= norfloxacin) and N-oxide derivatives. Some 60–70% of a dose, only about 10% of which is unchanged, appears in the urine; 25% of a dose appears in the feces, a small part contributed by elimination in the bile.
The half-life increases with hepatic impairment, but is virtually unaffected by renal failure. In patients on continuous ambulatory peritoneal dialysis (CAPD) given 800 mg followed by 400 mg every 12 h for 10–12 days, there was no significant accumulation of pefloxacin or its metabolite, norfloxacin, but concentrations of pefloxacin N-oxide rose continuously in plasma and dialysate; all concentrations fell rapidly when treatment was discontinued.
Adverse reactions are those common to the group . Most common are gastrointestinal tract disturbances, although some typical CNS reactions have been encountered. Skin eruptions (some photosensitive) occur and rashes appeared in about one-third of a group of patients who were given longterm therapy. Clinical uses are similar to those of ofloxacin.

Pefloxacin Preparation Products And Raw materials

Raw materials

Preparation Products


Pefloxacin Suppliers

Global( 99)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
Shaanxi Dideu Medichem Co. Ltd
18192627656
+86-29-88380327 1012@dideu.com CHINA 3949 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Hebei Crovell Biotech Co Ltd
+86-19930503285 +86-19930503285
86-0311-66562153 zoey@crovellbio.com China 3157 58
CD Chemical Group Limited
+8613651442114
0086-13651442114 info@codchem.com China 20383 58

View Lastest Price from Pefloxacin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Pefloxacin
70458-92-3
US $10.50 / KG 1KG 99% 1 ton Hebei Crovell Biotech Co Ltd
2021-07-22 Pefloxacin USP/EP/BP
70458-92-3
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
2020-05-14 Perfloxacin
70458-92-3
US $0.01-1.00 / KG 1ASSAYS 99% 50 tons Shaanxi Dideu Medichem Co. Ltd

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