Pefloxacin
- CAS No.
- 70458-92-3
- Chemical Name:
- Pefloxacin
- Synonyms
- PEFLOXACIN METHANESULFONATE;PEFLOXACIN MESYLATE DIHYDRATE;pefloxacine;1-Ethyl-4-oxo-6-fluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic acid;am725;1584rb;am-725;1589RB;RB-1589;EU-5306
- CBNumber:
- CB2304155
- Molecular Formula:
- C17H20FN3O3
- Molecular Weight:
- 333.36
- MDL Number:
- MFCD00865015
- MOL File:
- 70458-92-3.mol
| Melting point | 270-272° (dec) |
|---|---|
| Boiling point | 529.1±50.0 °C(Predicted) |
| Density | 1.320±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 0.16±0.20(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 70458-92-3(CAS DataBase Reference) |
| FDA UNII | 2H52Z9F2Q5 |
| ATC code | J01MA03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| Toxicity | LD50 in mice (mg/kg): 225 i.v., 1000 orally; in rats (g/kg): 1.5 i.p., 2.5 orally (Goueffon) |
Pefloxacin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 241178 | Pefloxacin | 70458-92-3 | 1g | $156 | 2021-12-16 | Buy |
| Usbiological | 462119 | Pefloxacin Mesylate Dihydrate | 70458-92-3 | 5g | $305 | 2021-12-16 | Buy |
| Usbiological | 287889 | Pefloxacin | 70458-92-3 | 25g | $398 | 2021-12-16 | Buy |
| TRC | P218350 | Pefloxacinium | 70458-92-3 | 1g | $670 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb593388 | Pefloxacin | 70458-92-3 | 500μg | $957.1 | 2021-12-16 | Buy |
Pefloxacin Chemical Properties,Uses,Production
Uses
antibacterial;DNA gyrase inhibitor
Uses
Pefloxacin Mesylate Dihydrate is an analog of norfloxacin that inhibits topoisomerase.
Definition
ChEBI: A quinolone that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6 and 7 by ethyl, carboxy, fluorine, and 4-methylpiperazin-1-yl groups, respectively.
Pharmaceutical Applications
A 6-fluoro, 7-piperazinyl quinoline available for oral and intravenous administration. The in-vitro activity is very similar to that of norfloxacin . It is active against H. ducreyi, V. cholerae and Legionella spp., but Campylobacter and Acinetobacter spp. and pseudomonads are not susceptible. It has poor activity against pneumococci, chlamydiae, mycoplasmas and ureaplasmas. L. monocytogenes, Nocardia spp. and anaerobes are resistant.
A plasma concentration of c. 5 mg/L is achieved 1–1.5 h after a 400 mg oral dose. The plasma elimination half-life is 8.5–15 h. It is widely distributed, concentrations in bone, brain, blister fluid, CSF, saliva, sputum and prostate all approximating, and in some cases exceeding, the simultaneous plasma concentration. It is extensively metabolized to the desmethyl (= norfloxacin) and N-oxide derivatives. Some 60–70% of a dose, only about 10% of which is unchanged, appears in the urine; 25% of a dose appears in the feces, a small part contributed by elimination in the bile.
The half-life increases with hepatic impairment, but is virtually unaffected by renal failure. In patients on continuous ambulatory peritoneal dialysis (CAPD) given 800 mg followed by 400 mg every 12 h for 10–12 days, there was no significant accumulation of pefloxacin or its metabolite, norfloxacin, but concentrations of pefloxacin N-oxide rose continuously in plasma and dialysate; all concentrations fell rapidly when treatment was discontinued.
Adverse reactions are those common to the group . Most common are gastrointestinal tract disturbances, although some typical CNS reactions have been encountered. Skin eruptions (some photosensitive) occur and rashes appeared in about one-third of a group of patients who were given longterm therapy. Clinical uses are similar to those of ofloxacin.
Pefloxacin Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 3422 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5964 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
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View Lastest Price from Pefloxacin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-06 | Pefloxacin
70458-92-3
|
US $10.50 / KG | 1KG | 99% | 1 ton | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2023-02-13 | Pefloxacin
70458-92-3
|
US $90.00 / kg | 1kg | 99% | 100MT | Hebei baicao biology science and technology co., ltd | |
 |
2022-10-19 | Pefloxacin
70458-92-3
|
US $50.00 / kg | 1kg | 99% | 1 | Hebei Duling International Trade Co. LTD |
-
- Pefloxacin
70458-92-3
- US $10.50 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- Pefloxacin
70458-92-3
- US $90.00 / kg
- 99%
- Hebei baicao biology science and technology co., ltd
-
- Pefloxacin
70458-92-3
- US $50.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD