ChemicalBook >> CAS DataBase List >>4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER structure

CAS No.: 183673-66-7

Chemical Name:: 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

Synonyms: FMOC-PIP(BOC)-OH;Fmoc-L-Pip(Boc)-OH;1-BOC-4-FMOC-PIP-OH;FMOC-4,4-ACP(1-N-BOC);BOC-PIC(4)(4-NHBOC)-OH;1-N-Boc-4-N-Fmoc-Aminopiperi;1-BOC-4-N-FMOC-AMINO-PIPERIDINE;1-Boc-4-(Fmoc-amino)piperidine-4;1-N-BOC-4-N-FMOC-AMINO-4-CARBOXYLIC-PIPERIDINE;1-BOC-PIPERIDINE-4-FMOC-AMINO-4-CARBOXYLIC ACID

CBNumber:: CB2673000

Molecular Formula:: C26H30N2O6

Molecular Weight:: 466.53

MDL Number:: MFCD01318741

MOL File:: 183673-66-7.mol

MSDS File:: SDS

Last updated:2025-09-12 14:32:05

Product description	Number	Pack Size	Price
N-Boc-amino-(4-N-Fmoc-piperidinyl)carboxylicAcid	B619250	250mg	$70
1-Boc-4-(Fmoc-amino)-4-piperidinecarboxylicacid 97%	OR953106	500mg	$110
1-Boc-4-(Fmoc-amino)-4-piperidinecarboxylicacid 97%	OR953106	1g	$176
N-Fmoc-Amino-(4-N-Boc-piperidinyl)carboxylicacid	V1376	1g	$178
N-Boc-amino-(4-N-fmoc-piperidinyl)carboxylic acid	FB18901	500mg	$255
More product size

Request For Quotation

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Properties

Melting point	80-82 °C
Boiling point	569.36°C (rough estimate)
Density	1.2464 (rough estimate)
refractive index	1.5300 (estimate)
storage temp.	Inert atmosphere,2-8°C
pka	3.80±0.20(Predicted)
Appearance	White to off-white Solid
CAS DataBase Reference	183673-66-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
F	10
HS Code	29225090

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B619250	N-Boc-amino-(4-N-Fmoc-piperidinyl)carboxylicAcid	183673-66-7	250mg	$70	2021-12-16	Buy
Apolloscientific	OR953106	1-Boc-4-(Fmoc-amino)-4-piperidinecarboxylicacid 97%	183673-66-7	500mg	$110	2021-12-16	Buy
Apolloscientific	OR953106	1-Boc-4-(Fmoc-amino)-4-piperidinecarboxylicacid 97%	183673-66-7	1g	$176	2021-12-16	Buy
AK Scientific	V1376	N-Fmoc-Amino-(4-N-Boc-piperidinyl)carboxylicacid	183673-66-7	1g	$178	2021-12-16	Buy
Biosynth Carbosynth	FB18901	N-Boc-amino-(4-N-fmoc-piperidinyl)carboxylic acid	183673-66-7	500mg	$255	2021-12-16	Buy

Product number	Packaging	Price	Buy
B619250	250mg	$70	Buy
OR953106	500mg	$110	Buy
OR953106	1g	$176	Buy
V1376	1g	$178	Buy
FB18901	500mg	$255	Buy

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Chemical Properties,Uses,Production

Chemical Properties

N-Boc-amino-(4-N-Fmoc-piperidinyl)carboxylic Acid is white to cream crystalline powder or chunks

Uses

N-Boc-amino-(4-N-Fmoc-piperidinyl)carboxylic acid is used in the preparation of synthetic peptide amides as kappa opioid receptor agonists for treatment of pain, pruritis and inflammation associated w ith a variety of diseases.

Uses

Cyclic ?,?-disubstituted amino acid for the preparation of water-soluble highly helical peptides.

Synthesis

28920-43-6

4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID

183673-71-4

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

183673-66-7

The general procedure for the synthesis of 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid from methyl chloroformate-9-fluorenylmethyl and 4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid was as follows: 4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid (5 g, 20.5 mmol) was dissolved in THF (300 mL), an aqueous solution of Na2CO3 (6.45 g, 61.5 mmol, 3.0 eq.) was added (64.5 mL) and cooled to 0 °C. A THF solution (30 mL) of methyl 9-fluorenyl chloroformate (5.3 g, 30.7 mmol, 1.5 eq.) was added slowly and dropwise. The reaction mixture was gradually warmed to 25 °C and stirring was continued for 12 hours. After completion of the reaction, the reaction solution was carefully acidified with 1 M HCl and the crude product was extracted three times with EtOAc. The organic layers were combined, dried with Na2SO4, concentrated and purified by combiflash column chromatography (eluent: 0 to 10% MeOH/DCM) to afford the target product 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butyloxycarbonyl)piperidine-4-carboxylic acid (4.02 g, 42% yield). The product was confirmed by 1H NMR, 13C NMR and HRMS characterization.

References

[1] Organic Syntheses, 2005, vol. 81, p. 213 - 224
[2] Patent: WO2015/184349, 2015, A2. Location in patent: Paragraph 0225-0226

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

9-Fluorenylmethyl chloroformate 4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID Sodium carbonate Tetrahydrofuran

Preparation Products

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Suppliers

Global( 179)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29798	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
GL Biochem (Shanghai) Ltd.	+86-021-61263370 +86-18901917034		CHINA	3904	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
GL Biochem (Shanghai) Ltd.	58

View Lastest Price from 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-09-11	4-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 183673-66-7	US $34.00-52.00 / mg		99.90%	10g	TargetMol Chemicals Inc.
	2020-01-05	4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 183673-66-7	US $7.00 / KG	1KG	99%	100KG	Career Henan Chemical Co

4-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester
183673-66-7
US $34.00-52.00 / mg
99.90%
TargetMol Chemicals Inc.

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
183673-66-7
US $7.00 / KG
99%
Career Henan Chemical Co

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER Spectrum

4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER(183673-66-7)¹HNMR

183673-66-7(4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER)Related Search:

N-BOC-ISONIPECOTIC ACID 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 1-Boc-4-Methylaminopiperidine FMOC-D-DAB(FMOC)-OH 1-Amino-1-cyclohexanecarboxylic acid

FMOC-DAB(BOC)-OH 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde tert-Butyl N-(3-aminopropyl)-N-methylcarbamate N-Boc-4-piperidinemethanol Ethyl 4-hydroxypiperidine-1-carboxylate

4-Amino-1-Boc-piperidine 1-Boc-piperidine 1-BOC-4-METHYLPIPERIDINE Isopropyl 4-aminopiperidine-1-carboxylate FMOC-D-DAB-OH

FMOC-DAB-OH HCL Propamocarb Fmoc-Aib-OH

1of4

1-(TERT-BUTOXYCARBONYL)-4-([(9H-FLUOREN-9-YLMETHOXY)CARBONYL]AMINO)PIPERIDINE-4-CARBOXYLIC ACID 1-(TERT-BUTOXYCARBONYL)-4-FLUORENYLMETHOXYCARBONYLAMINOPIPERIDINE-4-CARBOXYLIC ACID 1-N-BOC-4-N-FMOC-AMINO-4-CARBOXYLIC-PIPERIDINE 1-N-BOC-4-N-FMOC-AMINOPIPERIDINE-4-CARBOXYLIC ACID 1-BOC-4-FMOC-PIP-OH 1-BOC-4-(FMOC-AMINO)-PIPERIDINE-4-CARBOXYLIC ACID 1-BOC-PIPERIDINE-4-FMOC-AMINO-4-CARBOXYLIC ACID 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER 4-(FMOC-AMINO)-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID 4-[[(9H-Fluoren-9-ylMethoxy)carbonyl]aMino]-1,4-piperidinedicarboxylic Acid 1-(1,1-DiMethylethyl) Ester 1-BOC-4-N-FMOC-AMINO-PIPERIDINE 1-Boc-4-(FMoc-aMino)-4-piperidinecarboxylic acid BOC-PIC(4)(4-NHBOC)-OH FMOC-4,4-ACP(1-N-BOC) FMOC-4-AMINO-1-BOC-PIPERIDINE-4-CARBOXYLIC ACID N-ALPHA,GAMMA-DI-T-BUTOXYCARBONYL-4-AMINO-4-PIPECOLIC ACID N-BOC-4-N-FMOC-AMINO-4-PIPERIDINYLCARBOXYLIC ACID N-BOC-4-(FMOC-AMINO)PIPERIDINE-4-CARBOXYLIC ACID N-(9-FLUORENYLMETHOXYCARBONYL)-AMINO-(4-N-(TERT-BUTOXYCARBONYL)-PIPERIDINYL)CARBOXYLIC ACID 1-[(tert-butoxy)carbonyl]-4-[(9H-fluoren-9-ylMethoxy)carbonyl]piperidine-4-carboxylic acid N-FMOC-AMINO-(4-N-BOC-PIPERIDINYL) CARBOXYLIC ACID 4-(((9H-fluoren-9-yl)Methoxy)carbonylaMino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid 4-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic aci 1-Boc-piperidine-4-Fmoc-amino-4-carboxylic acid≥ 97% (HPLC) Fmoc-L-Pip(Boc)-OH 1-Boc-4-(N-Fmoc-amino)piperidine-4-carboxylic acid 1,4-Piperidinedicarboxylicacid,4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-,1-(1,1-dimethylethyl)ester(9CI) 1-Boc-piperidine-4-N-Fmoc-amino-4-carboxylicacid N-FMOC-Amino-(4-N-BOC-piperidinyl)carboxylicacid,95% 1-N-Boc-4-N-Fmoc-Aminopiperi 4-N-Fmoc-amino-1-N-Bocpiperidine-4-carboxylic acid 1-(N-Boc)-4-(Fmoc-amino)-piperidine-4-carboxylic acid 4-(((9H-fluoren-9-yl)methoxy)carbonyl)-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid 1-(tert-butoxycarbonyl)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-4-piperidinecarboxylic acid 4-(9H-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylicaci 4-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER USP/EP/BP 4-(9H-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-carboxylic acid FMOC-PIP(BOC)-OH 1-Boc-4-(Fmoc-amino)piperidine-4 1-(1,1-Dimethylethyl) 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1,4-piperidinedicarboxylate 1-Boc-Pi'ceridine-4-Fmoc-amino-4-carboxylic acid 4-(9H-fluoren-9-ylmethoxycarbonylamino)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester, 10 mM in DMSO 183673-66-7 83673-66-7 C26H30N2O6 Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Others Heterocycles Others Peptide Synthesis Unnatural Amino Acid Derivatives FMOC amino acids Amino Acid Derivatives Amino Acids & Derivatives