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Levobupivacaine hydrochloride

Levobupivacaine hydrochloride
Levobupivacaine hydrochloride structure
CAS No.
27262-48-2
Chemical Name:
Levobupivacaine hydrochloride
Synonyms
BUPIVACAINE HCL;(S)-Bupivacaine;LEVAMISOLHCLSALT;L-(-)-Bupivacaine;LEVOBUPIVACAINE HCL;TIMTEC-BB SBB001337;(S)-(-)-Bupivacaine;Bupivacaine Impurity 1;(S)-(-)-BUPIVACAINE HCL;bupicainehydrochloride(-)
CBNumber:
CB3408801
Molecular Formula:
C18H29ClN2O
Formula Weight:
324.89
MOL File:
27262-48-2.mol

Levobupivacaine hydrochloride Properties

Melting point:
254 °C (dec.)(lit.)
alpha 
-12.5 º (c=2, water)
storage temp. 
2-8°C
solubility 
H2O: soluble20mg/mL, clear
form 
powder
color 
white to beige
optical activity
[α]/D -10 to -14°, c = 1.0 in H2O
InChIKey
SIEYLFHKZGLBNX-NTISSMGPSA-N
CAS DataBase Reference
27262-48-2(CAS DataBase Reference)
FDA UNII
J998RDZ51I
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  T+,Xn
Risk Statements  26/27/28-20/21/22-28
Safety Statements  22-36/37/39-45-36/37-53
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  TK6125000

Levobupivacaine hydrochloride price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1092 Levobupivacaine hydrochloride ≥98% (HPLC) 27262-48-2 10mg $71.6 2019-12-02 Buy
Sigma-Aldrich SML1092 Levobupivacaine hydrochloride ≥98% (HPLC) 27262-48-2 50mg $277 2019-12-02 Buy
Alfa Aesar H37643 Levobupivacaine hydrochloride 98% 27262-48-2 1g $413 2020-06-24 Buy
Alfa Aesar H37643 Levobupivacaine hydrochloride 98% 27262-48-2 250mg $138 2020-06-24 Buy

Levobupivacaine hydrochloride Chemical Properties,Uses,Production

Description

Levobupivacaine was first launched in the US for the production of local anesthesia for surgery and obstetrics and for post-operative pain management. It is the (S)-enantiomer of the long acting, highly potent local anesthetic bupivacaine (Marcaine) that can be prepared by a three step sequence from (S)-pipecolic acid or from (S)-lysine by oxidative deamination and stereospecific ring closure to (S)-pipecolamide core structure. Levobupivacaine exhibits its long-acting local anesthetic effect by blocking neuronal sodium channel ion flow in nerve axons. Clinical studies demonstrated an efficacy and a general profile closely resembling those of the racemic bupivacaine currently in use; however, it produced an enhanced safety profile, in particular substantially reduced (about one-third) cardiotoxicity (less effect on myocardial contractility and QT, prolongation) and CNS depressive side effects. Onset and duration of blockade were also equivalent or even better.

Chemical Properties

white crystalline powder

Originator

Chiroscience (UK)

Uses

Local anesthetic; analgesic.

Definition

ChEBI: The monohydrochloride salt of levobupivacaine.

brand name

Chirocaine (Purdue).

Biological Functions

Levobupivacaine hydrochloride (Chirocaine) is the S-enantiomer of bupivacaine. It too has long action. Animal studies show that it has less CNS and cardiac toxicity than does bupivacaine. It also is slightly more motor sparing than is bupivacaine.

Levobupivacaine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Levobupivacaine hydrochloride Suppliers

Global( 195)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 301 58
Xingtai Haoxun Import and Export Trade Co., Ltd.
+8617733977883 WhatsApp:+8617733976525
86-0319-5021664 lisa@xthaoxun.com CHINA 299 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1009 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 304 58
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872
christine@shengqipharm.com CHINA 556 58

View Lastest Price from Levobupivacaine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-17 Levobupivacaine hydrochloride
27262-48-2
US $10.00 / KG 1KG 99% 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2020-07-20 Levobupivacaine hydrochloride
27262-48-2
US $5.00 / KG 10g 99 1tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2020-05-15 levobupivacaine hydrochloride (anhydrous)
27262-48-2
US $100.00 / KG 1KG Above 99% 5000kg/month Shijiazhuang Suking Biotechnology Co .,Ltd. Co., Ltd.

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