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Imazalil

Description References
Imazalil
Imazalil structure
CAS No.
35554-44-0
Chemical Name:
Imazalil
Synonyms
MAZAL;r23979;Magnate;R 23979;FLO-PRO;Fcundal;Florasan;Fecundal;Imaverol;DECCOZIL
CBNumber:
CB4251497
Molecular Formula:
C14H14Cl2N2O
Formula Weight:
297.18
MOL File:
35554-44-0.mol

Imazalil Properties

Melting point:
52.7°C
Boiling point:
>340°C
Density 
1.348
vapor pressure 
1.58 x l0-4 Pa (20 °C)
refractive index 
1.5680 (estimate)
storage temp. 
Sealed in dry,2-8°C
pka
6.53 (weak base)
form 
neat
Water Solubility 
0.018 g/100 mL
Merck 
13,3616
BRN 
545683
InChIKey
PZBPKYOVPCNPJY-UHFFFAOYSA-N
CAS DataBase Reference
35554-44-0(CAS DataBase Reference)
EWG's Food Scores
3
FDA UNII
6K0NOF3XQ6
Proposition 65 List
Imazalil
NIST Chemistry Reference
Imazalil(35554-44-0)
EPA Substance Registry System
Imazalil (35554-44-0)
Pesticides: Freedom of Information Act (FOIA)
Imazalil
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS06,GHS09,GHS07
Signal word  Danger
Hazard statements  H301-H318-H332-H410-H302+H332
Precautionary statements  P261-P280-P305+P351+P338+P310-P273-P305+P351+P338-P501
Hazard Codes  Xn,N
Risk Statements  20/22-41-50/53
Safety Statements  26-39-60-61
RIDADR  2588
WGK Germany  3
RTECS  NI4776000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29332900

Imazalil price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 32007 Imazalil PESTANAL 35554-44-0 100mg $96 2021-12-16 Buy
Sigma-Aldrich Y0000136 Enilconazole European Pharmacopoeia (EP) Reference Standard 35554-44-0 y0000136 $190 2021-12-16 Buy
Sigma-Aldrich Y0000136 Enilconazole European Pharmacopoeia (EP) Reference Standard 35554-44-0 $190 2021-12-16 Buy
TRC I268503 Imazalil 35554-44-0 10g $110 2021-12-16 Buy
Usbiological 280708 Imazalil 35554-44-0 250mg $396 2021-12-16 Buy

Imazalil Chemical Properties,Uses,Production

Description

Imazalil (also known as Enilconazole) is a kind of topical mycotic agent that used for the treatment of fungi infections. It is primarily used for the treatment of fungi attracted to tubers of the crops, including Fusarium spp, Phoma spp, and Helminthosporum solani which reduces the crop quality. It can also be applied to citrus fruits. In addition, it can also be used for the treatment of Microsporum spp and Aspergillus spp infections occurring in the dogs, either as a single topic agent or being combined with oral administrated itraconazole or griseofulvin. The mechanism of action of Imazalil is through suppressing the biosynthesis pathway of ergosterol through blocking the demethylation process. 

References

http://www.vetbook.org/wiki/dog/index.php?title=Enilconazole
https://en.wikipedia.org/wiki/Enilconazole
https://www.mysciencework.com/publication/show/f0382c741754e9200388abe8cf2f0133

Description


Description

Imazalil is an imidazole fungicide that inhibits ergosterol biosynthesis. Imazalil inhibits the growth of various fungi in vitro including P. italicum, A. niger, U. maydis, B. alii, and C. cucumerinum in a pH-dependent manner (MICs = 0.005-2 μg/ml at pH 7). It inhibits S. cerevisiae, but not rat liver microsomal, cytochrome P450 enzymes (CYPs; IC50s = 0.088 and 80 μM, respectively), as well as aromatase CYP19 from human placental microsomes (IC50 = 0.34 μM). Imazalil activates the murine pregnane X receptor (PXR) in a concentration-dependent manner in a cell-based reporter assay. It increases hepatic CYP3A11 and CYP2B10 mRNA levels in mice when administered at a dose of 100 mg/kg. Imazalil also increases Ki-67-positive nuclei in liver sections and hepatic MCM2 mRNA levels, markers of cell proliferation, in mice when co-administered with the murine constitutive androstane receptor (mCAR) agonist TCPOBOP (Item No. 14140). Formulations containing imazalil have been used to control fungal infection in agriculture.

Uses

antifungal

Uses

As a disinfectant for stable and kennel equipment; experimentaly as an agricultural fungicide.

Uses

Imazalil is a systemic fungicide with protective and curative action. It is used for the control of a wide range of fungal diseases on fruit, vegetables and ornamentals, powdery mildew on roses and storage diseases of citrus fruit, pome fruit, bananas and seed potatoes. It is also used as a seed dressing, for control of diseases of cereals (particularly Fusarium and Helminthosporium spp.), and it is particularly active against benzimidazole-resistant strains of plant-pathogenic fungi.

General Description

Slightly yellow to brown solidified oil. Non-corrosive. Used as a fungicide.

Air & Water Reactions

Water soluble.

Reactivity Profile

Imazalil is an imidazole derivative.

Safety Profile

Poison by ingestion and intraperitoneal routes. Experimental reproductive effects. A skin and eye irritant. When heated to decomposition it emits toxic fumes of Cland NOx.

Veterinary Drugs and Treatments

Although no dosage forms are currently commercially available for topical use in the USA, Enilconazole is used topically for treating dermatophytosis in small animals and horses using compounded products. A commercially available topical rinse Imaverol? (Janssen) 10% is available with canine, bovine and equine use labeling in many countries. Intranasal instillation of enilconazole after plaque debridement has also been shown useful in treating nasal aspergillosis in small animals.
Use of topical enilconazole on cats with dermatophytosis is somewhat controversial as there are apparently no products with feline labeling available in Europe or Canada. There are preliminary reports of safely and successfully using enilconazole on dermatophytic cats in combination with oral itraconazole.
A topical product and a poultry environmental disinfectant product (Clinafarm EC?) is available in the USA. It is technically illegal to use this product other than it is labeled; it is an EPA licensed product in the USA.

Metabolic pathway

Published information is available on the metabolism of imazalil in plants and soils. The principal metabolite in plants and soils is 1-[2-(2,4- dichlorophenyl)-2-hydroxyethyl]-1H-imidazole.

Degradation

Imazalil is very stable to hydrolysis in dilute acids and alkalis at room temperature, in the absence of light. It is also stable to light under normal storage conditions.

Imazalil Preparation Products And Raw materials

Raw materials

Preparation Products


Imazalil Suppliers

Global( 215)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5942 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Shaanxi Dideu Medichem Co. Ltd
15319487004
029-88380327 1015@dideu.com CHINA 3994 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58

View Lastest Price from Imazalil manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-30 Imazalil
35554-44-0
US $62.00 / KG 1Kg/Bag 99% 2000T Baoji Guokang Bio-Technology Co., Ltd.
2021-11-15 Imazalil
35554-44-0
US $110.00 / KG 10KG 99.9% 100tons Hebei Yirun Sega Biological Technology Co. Ltd
2021-07-20 Imazalil
35554-44-0
US $0.00-0.00 / KG 1g 99% 20tons Shaanxi Dideu Medichem Co. Ltd

Imazalil Spectrum


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