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SIGUAZODAN

SIGUAZODAN Structure
SIGUAZODAN structure
CAS No.
115344-47-3
Chemical Name:
SIGUAZODAN
Synonyms
SKF 94836;SIGUAZODAN;SK AND F-94836;Siguazodan (SKF 94836);SKF-94836,inhibit,Phosphodiesterase (PDE),SKF94836,Siguazodan,Inhibitor;N-Cyano-Nmethyl-Nⅱ-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine;N-CYANO-N'-METHYL-N''-[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL]GUANIDINE;Guanidine, N-cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-;4β-Methyl-4,5-dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]pyridazin-6(1H)-one;Siguazodan, N-Cyano-Nμ-methyl-N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine
CBNumber:
CB6229034
Molecular Formula:
C14H16N6O
Molecular Weight:
284.32
MDL Number:
MFCD00867103
MOL File:
115344-47-3.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:05
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SIGUAZODAN Properties

Melting point 268-268.9 °C(lit.)
Density 1.31±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >5 mg/mL, freely soluble
pka 13.71±0.60(Predicted)
form solid
color white
FDA UNII 5E4UI00UQJ

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H335-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3

SIGUAZODAN price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 1148 Siguazodan ≥99%(HPLC) 115344-47-3 10 $122 2021-12-16 Buy
Tocris 1148 Siguazodan ≥99%(HPLC) 115344-47-3 50 $510 2021-12-16 Buy
TRC S497058 Siguazodan 115344-47-3 5mg $330 2021-12-16 Buy
Usbiological 256668 Siguazodan 115344-47-3 10mg $423 2021-12-16 Buy
ChemScene CS-0014736 Siguazodan >99.0% 115344-47-3 5mg $350 2021-12-16 Buy
Product number Packaging Price Buy
1148 10 $122 Buy
1148 50 $510 Buy
S497058 5mg $330 Buy
256668 10mg $423 Buy
CS-0014736 5mg $350 Buy

SIGUAZODAN Chemical Properties,Uses,Production

Uses

Siguazodan is a selective phosphodiesterase PDE III inhibitor and a potent inotropic agent.

Definition

ChEBI: 1-cyano-2-methyl-3-[4-(4-methyl-6-oxo-4,5-dihydro-1H-pyridazin-3-yl)phenyl]guanidine is a pyridazinone.

Biological Activity

Phosphodiesterase inhibitor, selective for PDE3 (IC 50 = 117 nM).

SIGUAZODAN Preparation Products And Raw materials

Raw materials

Preparation Products

SIGUAZODAN Suppliers

Global( 56)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9440 58
Shanghai Changyu Medical Technology Co. Ltd. +86-13301875428 sales@changyuhe.com China 288 58
BOC Sciences -- info@bocsci.com USA 0 65
Jinan ponder chemical co. LTD 0531-0000 thinklifescience@163.com China 19690 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Shanghai Changyu Medical Technology Co. Ltd. 58
BOC Sciences 65
Jinan ponder chemical co. LTD 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

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(4S)-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]PYRROLIDIN-2-ONE CILOSTAMIDE EHNA HYDROCHLORIDE 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE SIGUAZODAN
(R)-6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone Dicyandiamide N-CYANO-N',N'-DIMETHYLGUANIDINE

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SIGUAZODAN SK AND F-94836 SKF 94836 N-CYANO-N'-METHYL-N''-[4-(1,4,5,6-TETRAHYDRO-4-METHYL-6-OXO-3-PYRIDAZINYL)PHENYL]GUANIDINE N-Cyano-Nmethyl-Nⅱ-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine Siguazodan, N-Cyano-Nμ-methyl-N-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]guanidine Siguazodan (SKF 94836) [4R,(-)]-4,5-Dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]-4-methylpyridazin-6(1H)-one [4S,(+)]-4,5-Dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]-4-methylpyridazin-6(1H)-one 4β-Methyl-4,5-dihydro-3-[4-[[(cyanoimino)(methylamino)methyl]amino]phenyl]pyridazin-6(1H)-one Guanidine, N-cyano-N'-methyl-N''-[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]- SKF-94836,inhibit,Phosphodiesterase (PDE),SKF94836,Siguazodan,Inhibitor 115344-47-3 C14H16N6O Cell Biology Cell Signaling and Neuroscience BioChemical G Proteins and Cyclic Nucleotides Phosphodiesterase Inhibitors Cyclic Nucleotide Metabolism Cyclic Nucleotide related