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methoxyflurane

methoxyflurane
methoxyflurane structure
CAS No.
76-38-0
Chemical Name:
methoxyflurane
Synonyms
MOF;MOZ;hMOF;KAT8;KAT6A;MYST3;MYST1;DA-759;ZNF220;Inhalan
CBNumber:
CB6314297
Molecular Formula:
C3H4Cl2F2O
Formula Weight:
164.97
MOL File:
76-38-0.mol

methoxyflurane Properties

Melting point:
-36°C
Boiling point:
103 °C
Density 
1.4262
refractive index 
1.386
Flash point:
37°C
storage temp. 
-70°C
Water Solubility 
Miscible with alcohol, acetone, chloroform, ether, fixed oils and benzene. Immiscible with water.
Merck 
14,5994
BRN 
1737766
Exposure limits
No exposure limit is set. Based on comparison with related compounds, a TLV-TWA of 675 mg/m3 (100 ppm) is recommended.
Stability:
Stability
CAS DataBase Reference
76-38-0(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02,GHS07,GHS08
Hazard statements  H226-H319-H341
Precautionary statements  P201-P210-P303+P361+P353-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  10
Safety Statements  23-24/25
RIDADR  3271
RTECS  KN7820000
Hazard Note  Irritant
HazardClass  3
PackingGroup  III
HS Code  2909191800

methoxyflurane price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar L17285 2,2-Dichloro-1,1-difluoroethyl methyl ether, 97% 76-38-0 5g $74 2018-11-13 Buy
Alfa Aesar L17285 2,2-Dichloro-1,1-difluoroethyl methyl ether, 97% 76-38-0 25g $286 2018-11-13 Buy

methoxyflurane Chemical Properties,Uses,Production

Chemical Properties

colourless liquid

Uses

Methoxyflurane is a very potent and highly lipid soluble anesthetic agent. Methoxyflurane causes deep sedation and it has been used as a patient controlled analgesic for painful procedures in children. Methoxyflurane is a significant respiratory depressant.

Uses

Methoxyflurane is used as a clinical anesthesia (inhalation).

Definition

ChEBI: An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.

brand name

Penthrane (Abbott).

Biological Functions

Methoxyflurane (Penthrane) is the most potent inhalational agent available, but its high solubility in tissues limits its use as an induction anesthetic. Its pharmacological properties are similar to those of halothane with some notable exceptions. For example, since methoxyflurane does not depress cardiovascular reflexes, its direct myocardial depressant effect is partially offset by reflex tachycardia, so arterial blood pressure is better maintained. Also, the oxidative metabolism of methoxyflurane results in the production of oxalic acid and fluoride concentrations that approach the threshold of causing renal tubular dysfunction. Concern for nephrotoxicity has greatly restricted the use of methoxyflurane.

General Description

Methoxyflurane is a volatile liquid (bp=105°C) with a highblood:gas partition coefficient and thus a slow induction andprolonged recovery. Approximately 75% of the drug undergoesmetabolism yielding dichloroacetate, difluoromethoxyacetate,oxalate, and fluoride ions. The intrarenal inorganicfluoride concentration, as a result of renal defluorination, maybe responsible for the nephrotoxicity seen with methoxyflurane.Both the concentration of F- generated and the durationfor which it remained elevated were factors in the developmentof methoxyflurane nephrotoxicity. Methoxyfluranewas removed from the U.S. market in 2000 because of saferalternatives. Both isoflurane and enflurane produce less fluorideion upon metabolism than methoxyflurane.

General Description

Clear colorless liquid with a sweet fruity odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,2-DICHLORO-1,1-DIFLUOROETHYL METHYL ETHER may be sensitive to prolonged exposure to light.

Health Hazard

Methoxyflurane exhibited low to very lowacute toxicity via inhalation, slightly lowerthan that of ethrane. Oral toxicity was low tomoderate depending on the species. Inhala tion of its vapors at 1.5–2% by volumeconcentrations in air can cause anesthesia inhumans. The toxic symptoms are similar tothose of ethrane, and the target organs areprimarily the central nervous system, kidney,and liver. At subanesthetic concentrations of0.3–0.5% by volume in air, its exposure tohumans for 1 hour resulted in the onset oflow toxicity. The sites of biological effectswere in the kidney.
LC50 value, inhalation (mice): 17,500 ppm/2 hr
LD50 value, oral (mammals): 3600 mg/kg
The liquid may be an irritant to theeyes. The teratomeric properties of this com pound were observed in rats and mice. Thesymptoms were embryo deaths and develop mental abnormalities in the urogenital andmusculoskeletal systems.
No carcinogenic actions in animals orhumans have been reported. The histidinereversion–Ames test for mutagenicity wasinconclusive.

Fire Hazard

2,2-DICHLORO-1,1-DIFLUOROETHYL METHYL ETHER is combustible.

Veterinary Drugs and Treatments

Methoxyflurane is an inhalant anesthetic, but it is rarely used today primarily due to its potential for causing nephrotoxicity, slow onset of action (a short-acting barbiturate is often used as an induction agent), and prolonged recovery time. However, it does produce some muscle relaxation and analgesia, even at relatively low concentrations and can be administered without a precision vaporizer as it will vaporize to a maximum of about 3%.

methoxyflurane Preparation Products And Raw materials

Raw materials

Preparation Products


methoxyflurane Suppliers

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