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4-Trifluoromethylphenol

4-Trifluoromethylphenol structure

CAS No.: 402-45-9

Chemical Name:: 4-Trifluoromethylphenol

Synonyms: 4-(TRIFLUOROMETHYL)PHENOL;TFMPO;P-Trifluoromethyl;TRIFLUORO-PARA-CRESOL;Fluoxetine Impurity 4;4-HYDROXYBENZOTRIFLUORI;4-trifluorotoluolphenol;p-TrifluoroMethylphenyl;α,α,α-Trifluoro-p-cresol;Fluoxetine EP Impurity D

CBNumber:: CB6371577

Molecular Formula:: C7H5F3O

Molecular Weight:: 162.11

MDL Number:: MFCD00002363

MOL File:: 402-45-9.mol

MSDS File:: SDS

Last updated:2023-11-02 15:05:42

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4-Trifluoromethylphenol Properties

Melting point	45-47 °C(lit.)
Boiling point	71.5-72 °C (8 mmHg)
Density	1.3226 (estimate)
Flash point	183 °F
storage temp.	Store at <= 20°C.
Water Solubility	Insoluble in water
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	pK1:8.675 (25°C)
form	Crystals
color	White to yellow-brown
BRN	1637019
Stability	Light Sensitive
InChIKey	BAYGVMXZJBFEMB-UHFFFAOYSA-N
CAS DataBase Reference	402-45-9(CAS DataBase Reference)
FDA UNII	G8PMO13PO4
NIST Chemistry Reference	p-Hydroxybenzotrifluoride(402-45-9)
EPA Substance Registry System	4-(Trifluoromethyl)phenol (402-45-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS06

Signal word

Danger

Hazard statements

H228-H301-H315-H318-H335

Precautionary statements

P210-P240-P280-P301+P310-P302+P352-P305+P351+P338

Hazard Codes

Xn,Xi

Risk Statements

22-37/38-41-36/37/38

Safety Statements

26-39-24/25

RIDADR

UN 2926 4.1/PG 2

WGK Germany

Hazard Note

Irritant/Keep Cold

PackingGroup

Ⅱ

HS Code

29081000

NFPA 704

	2
2		3

4-Trifluoromethylphenol price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.41244	4-Hydroxybenzotrifluoride for synthesis	402-45-9	1g	$53.1	2024-03-01	Buy
Sigma-Aldrich	178470	4-(Trifluoromethyl)phenol 97%	402-45-9	1g	$54.8	2024-03-01	Buy
Sigma-Aldrich	8.41244	4-Hydroxybenzotrifluoride for synthesis	402-45-9	5G	$215	2024-03-01	Buy
Sigma-Aldrich	178470	4-(Trifluoromethyl)phenol 97%	402-45-9	5g	$124	2024-03-01	Buy
TCI Chemical	H0644	4-Hydroxybenzotrifluoride >98.0%(GC)(T)	402-45-9	5g	$79	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.41244	1g	$53.1	Buy
178470	1g	$54.8	Buy
8.41244	5G	$215	Buy
178470	5g	$124	Buy
H0644	5g	$79	Buy

4-Trifluoromethylphenol Chemical Properties,Uses,Production

Preparation method

Chlorosilane and bromotrifluoromethane at-59℃form trifluoromethylsilane. Trifluoromethylsilane and benzoquinone in the presence of catalyst form 4-triethylsiloxy-4-trifluoromethyl-2,5-cyclohexadien-1-ketone which is reduced by zinc powder to p-trifluoromethylphenol with a yield of 71%. This method avoids the use of hydrofluoric acid in the traditional process but should be carried out under anhydrous conditions.If there were water trifluoromethyl silane would rapidly become silanol under the effect of water and alkali. The catalyst used in the reaction is alkali of which the strength has nothing to do with the catalytic activity. By now the role of catalyst is still unknown but the reaction can not proceed without catalyst.

Chemical Characteristics

Off-white crystal

Uses

For intermediate of medicine and pesticide.

Chemical Properties

White to yellowish-brown crystals

Uses

4-(Trifluoromethyl)phenol (4-hydroxybenzotrifluoride) was used in the synthesis of diaryl ether.

Uses

Intermediates of Liquid Crystals

Definition

ChEBI: 4-(trifluoromethyl)phenol is a member of the class of (trifluoromethyl)benzenes that is p-cresol in which the methyl group is perfluorinated. It is a metabolite of the drug fluoxetine. It has a role as a marine xenobiotic metabolite and a drug metabolite. It is a member of phenols and a member of (trifluoromethyl)benzenes. It is functionally related to a (trifluoromethyl)benzene and a p-cresol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 2873, 1989 DOI: 10.1021/jo00273a020

General Description

4-(Trifluoromethyl)phenol molecule, bound at the active site of H61T (His-61→Thr) mutant, shows strong density.

4-Trifluoromethylphenol synthesis

Synthesis of 4-Trifluoromethylphenol from 4-Chlorobenzotrifluoride

4-Trifluoromethylphenol Preparation Products And Raw materials

Raw materials

Trifluoromethanesulfonyl chloride 4-(Trifluoromethyl)benzaldehyde

Preparation Products

4-(TRIFLUOROMETHYL)PHENOXYACETIC ACID 4-Trifluoromethylsalicylic acid 2-Hydroxy-5-trifluoromethylbenzonitrile 2'-hydroxy-5'-(trifluoroMethyl)acetophenone 2-amino-alpha,alpha,alpha-trifluoro-p-creso

4-Hydroxy-3-nitrobenzotrifluoride 4-(Trifluoromethyl)phenyl acetate 4-(4-TRIFLUOROMETHYL-PHENOXY)-BENZALDEHYDE 6-METHOXY-2-METHYL-3-(TRIFLUOROMETHYL)BENZOIC ACID Propanoic acid, 2-methyl-2-[4-(trifluoromethyl)phenoxy]-

5-(Trifluoromethyl)benzoxazol-2(3H)-one

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4-Trifluoromethylphenol Suppliers

Global( 437)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Fluoropharm Co., Ltd.	+86-0571-85586753; +8613336034509	sales@fluoropharm.com	China	1377	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
QINGDAO HONG JIN CHEMCIAL CO.,LTD.	532-83657313	hjt@hong-jin.com	China	228	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Shanghai Worldyang Chemical Co.,Ltd.	,+86-21-56795779; +8613651600618	sales@worldyachem.com	China	879	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
QINGDAO HONG JIN CHEMCIAL CO.,LTD.	58
Hubei Jusheng Technology Co.,Ltd.	58
Shanghai Worldyang Chemical Co.,Ltd.	58
Xiamen AmoyChem Co., Ltd	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from 4-Trifluoromethylphenol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-02	4-Trifluoromethylphenol 402-45-9	US $0.00-0.00 / kg	1kg	99%	50000kg	Hebei Kingfiner Technology Development Co.Ltd
2022-02-21	4-(Trifluoromethyl)phenol 402-45-9	US $0.00 / KG	1KG	99.4%	100 tons	Honest Joy Holdings Limited
2019-07-06	4-Trifluoromethylphenol 402-45-9	US $100.00 / KG	1KG	99%	Customized	Career Henan Chemical Co

4-Trifluoromethylphenol
402-45-9
US $0.00-0.00 / kg
99%
Hebei Kingfiner Technology Development Co.Ltd

4-(Trifluoromethyl)phenol
402-45-9
US $0.00 / KG
99.4%
Honest Joy Holdings Limited

4-Trifluoromethylphenol
402-45-9
US $100.00 / KG
99%
Career Henan Chemical Co

4-Trifluoromethylphenol Spectrum

4-Trifluoromethylphenol(402-45-9)MS 4-Trifluoromethylphenol(402-45-9)¹HNMR 4-Trifluoromethylphenol(402-45-9)¹³CNMR 4-Trifluoromethylphenol(402-45-9)IR1 4-Trifluoromethylphenol(402-45-9)IR2 4-Trifluoromethylphenol(402-45-9)Raman

402-45-9(4-Trifluoromethylphenol)Related Search:

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alpha,alpha,alpha-Trifluoro-p-cresol,loosecrystals Phenol, 4-(trifluoromethyl)- P-HYDROXYBENZOTRIFLUORIDE P-(TRIFLUOROMETHYL)PHENOL ALPHA,ALPHA,ALPHA-TRIFLUORO-4-CRESOL ALPHA,ALPHA,ALPHA-TRIFLUORO-P-CRESOL 4-HYDROXYBENZOTRIFLUORIDE 4-HYDROXY-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE 4-Hydroxy-α,α,α-trifluorotoluene α,α,α-Trifluoro-p-cresol 4-Hydroxybenxotrifluoride ALPHA,ALPHA,ALPHA-TRIFLUORO-P-CRESOL, 99 % 4-HydroxytrifluoromethylBenzene 4-Hydroxybenzotrifluoride,98% 4-Hydroxybenzotrifluoride99% 4-Hydroxybenzotrifluoride 99% TRIFLUORO-PARA-CRESOL 4/p-Trifluoromethylaniline α,α,α-Trifluoro-p-cresol, 4-Hydroxybenzotrifluoride TFMPO alpha,alpha,alpha-Trifluoro-p-cresol,98% 4-HYDROXYBENZOTRIFLUORI 4-(Trifluoromethyl)phenol ,98% 4-trifluorotoluolphenol alpha,alpha,alpha-Trifluoro-p-cresol, 98% 1GR alpha,alpha,alpha-Trifluoro-p-cresol, 98% 5GR 4-Hydroxy-alpha,alpha,alpha-trifluorotoluene alpha,alpha,alpha-Trifluoro-p-cresol 4-(Trifluoromethyl)phenol p-TrifluoroMethylphenyl 4-(TrifluoroMethyl)phenol 97% 4-(TrifluoroMethyl)phenol, 97+% α,α,α-Trifluoro-p-cresol 4-Hydroxybenzotrifluoride 4-Hydroxy-α,α,α-trifluorotoluene p-Hydroxybenzotrifluoride p-Trifluoromethylphenol 4-Hydroxybenzotrifluoride for synthesis Fluoxetine EP Impurity D Fluoxetine Hydrochloride Impurity Ⅱ：4-Trifluoromethylphenol P-Trifluoromethyl Fluoxetine Impurity 4 Fluoxetine Impurity 4(EP-D) 4-Hydroxybenzotrifluoride> 4-Hydroxybenzotrifluoride (alpha-Trifluoro p-Cresol Fluoxetine Hydrochloride Impurity Ⅱ：4-Trifluoromethylphenol ?,?,?-trifluoro-p-cresol 4-(TRIFLUOROMETHYL)PHENOL Fluoxetine Impurity 4(Fluoxetine EP Impurity D) 402-45-9 402-56-9 C7H5F3O Building Blocks Oxygen Compounds Phenols Organic Building Blocks Fluorochemicals Trifluoromethylbenzene serise Aromatic Phenols Phenol&Thiophenol&Mercaptan bc0001