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Ofloxacin

Ofloxacin
Ofloxacin structure
CAS No.
82419-36-1
Chemical Name:
Ofloxacin
Synonyms
oflx;pt01;Oflox;floxin;hoe280;Exocin;Floxil;Floxal;Visren;oflocet
CBNumber:
CB7103599
Molecular Formula:
C18H20FN3O4
Formula Weight:
361.37
MOL File:
82419-36-1.mol

Ofloxacin Properties

Melting point:
270-2750C
Density 
1.2688 (estimate)
storage temp. 
2-8°C
solubility 
1 M NaOH: soluble50mg/mL
form 
neat
Water Solubility 
Soluble in acetic acid or water. Slightly soluble in methanol
λmax
326nm(H2O)(lit.)
Merck 
14,6771
CAS DataBase Reference
82419-36-1(CAS DataBase Reference)
EPA Substance Registry System
7H-Pyrido[1,2,3- de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-2,3-dihydro-3-methyl- 10-(4-methyl-1-piperazinyl)- 7-oxo-(82419-36-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,Xi
Risk Statements  22-42/43-68-36/37/38
Safety Statements  26-36/37/39-24/25-22-37/39-60
WGK Germany  3
RTECS  UU8815550
HS Code  29349990
Toxicity LD50 in male, female mice, male, female rats (mg/kg): 5450, 5290, 3590, 3750 orally; 208, 233, 273, 276 i.v.; >10000, >10000, 7070, 9000 s.c. (Ohno)
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
Precautionary statements:

Ofloxacin price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O8757 Ofloxacin fluoroquinolone antibiotic 82419-36-1 1g $46.9 2018-11-20 Buy
Sigma-Aldrich 33703 Ofloxacin VETRANAL 82419-36-1 100mg-r $53 2018-11-20 Buy
TCI Chemical O0403 Ofloxacin >98.0%(HPLC)(T) 82419-36-1 5g $88 2018-11-22 Buy
TCI Chemical O0403 Ofloxacin >98.0%(HPLC)(T) 82419-36-1 25g $295 2018-11-22 Buy
Alfa Aesar J62080 Ofloxacin 82419-36-1 5g $117 2018-11-13 Buy

Ofloxacin Chemical Properties,Uses,Production

Description

Ofloxacin is an antibacterial agent with increased potency in comparison to the prototype third generation quinolone, norfloxacin. It has a broad spectrum of activity against gram-positive and gram-negative bacteria and is useful in the treatment of kidney, genitourinary, and upper respiratory tract infections.

Chemical Properties

Off-White Solid

Originator

Daiichi Seiyaku (Japan)

Uses

Fluorinated quinolone antibacterial

Definition

ChEBI: An oxazinoquinolone carrying carboxy, fluoro, methyl and 4-methylpiperazino substituents. A synthetic fluoroquinolone antibacterial agent, it inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.

brand name

Floxin (Ortho-McNeil); Floxin (Daiichi Pharmaceutical); Ocuflox (Allergan);TARIVID.

Antimicrobial activity

It exhibits good activity against a wide range of enterobacteria, including strains resistant to nalidixic acid, as well as against Aeromonas, Campylobacter, Vibrio and Moraxella spp. Activity against methicillin-sensitive Staph. aureus is good, but streptococci, including Str. pneumoniae and enterococci, are less susceptible. Most anaerobes are moderately or completely resistant. It is active against L. pneumophila, Ch. pneumoniae, C. trachomatis, mycoplasmas, ureaplasmas and M. tuberculosis. Other mycobacteria such as M. fortuitum, M. kansasii, M. chelonei and the M. avium complex are moderately susceptible.

Pharmaceutical Applications

A tricyclic 6-fluoro, 7-piperazinyl quinoline with a methyl substituted oxazine ring substituted. It is a racemic mixture of l- (levofloxacin, see p. 319) and d-isomers.

Biotechnological Applications

Ofloxacin is a fluoroquinolone antibiotic present as a racemic mixture. Levofloxacin, S-isomer of ofloxacin, shows a broad spectrum of antibacterial activity against both gram-positive and gram-negative bacteria. The antibacterial activity of levofloxacin is 8–128 times greater than that of the corresponding R-isomer. A novel esterase of type B1 carboxylesterase/lipase family from a marine isolate Y. lipolytica CL180 was used to resolve a racemic mixture of ofloxacin ester. This esterase showed an enantioselectivity toward R, S-ofloxacin ester, and levofloxacin was produced with an enantiomeric excess of 52 % (Kim et al. 2007).

Pharmacokinetics

Oral absorption: c. 95%
Cmax400 mg oral: 3–5 mg/L after 1–1.5 h
200 mg intravenous (30-min infusion): 1.8 mg/L 1 h after end infusion
Plasma half-life: 5–7 h
Volume of distribution: 1–2.5 L/kg
Plasma protein binding: c. 25%
absorption and distribution
There is no significant interference with absorption by magnesium–aluminum hydroxide or calcium carbonate compounds,providing administration is separated by at least 2 h. In patients receiving repeated 200 mg doses, the mean peak plasma concentration rose from 2.7 mg/L after the first dose to 3.4 mg/L after the seventh.
It is widely distributed, achieving levels ≥50% of simultaneous plasma concentrations in many tissues, including lung and bronchial secretions. In cantharides and suction blisters, peak concentrations exceed those in plasma, while the elimination half-life is similar. In patients with non-inflamed meninges, 200 mg administered orally or by intravenous infusion over 30 min produced CSF concentrations of around 0.4–1 mg/L at 2–4 h while the plasma concentration was 1.7–4 mg/L: a 400 mg intravenous infusion yielded a CSF concentration of 2 mg/L, which is adequate for some Gram-negative bacteria, but not for Gram-positive bacteria or Ps. aeruginosa.
Metabolism and excretion
It is poorly metabolized into desmethyl and N-oxide derivatives (<5% of the administered dose), only about 20% of a dose being eliminated by non-renal routes. There is a very slight effect on cytochrome P450-related isoenzymes and no significant effect on the metabolism of theophylline in dosages of up to 800 mg.
About 60% of a dose appears in the urine over 12 h and 80–90% over 48 h. The apparent elimination half-life is prolonged in renal failure, reaching 30–50 h in anuria, necessitating a dosage reduction. The desmethyl metabolite accumulates in all patients and the N-oxide in 50%. Absorption and distribution are not affected by renal failure. Significant amounts of the drug appear in the feces, producing very variable concentrations up to 100 mg/kg.

Clinical Use

9-Fluoro-2,3-dihydro-3-methyl-10(4-methyl-1-piperazin-yl)-7-oxo-7H-pyrido[1,2,3-de]-1,4,-benzoxazine-6-carboxylicacid (Floxin, Floxin IV) is a member of the quinolone class of antibacterial drugs wherein the 1- and 8-positions are joined in the form of a 1,4-oxazine ring.
Ofloxacin has been approved for the treatment of infectionsof the lower respiratory tract, including chronic bronchitisand pneumonia, caused by Gram-negative bacilli. It isalso used for the treatment of pelvic inflammatory diseaseand is highly active against both gonococci and chlamydia.In common with other fluoroquinolones, ofloxacin is not effectivein the treatment of syphilis. A single 400-mg oraldose of ofloxacin in combination with the tetracycline antibioticdoxycycline is recommended by the Centers forDisease Control and Prevention (CDC) for the outpatienttreatment of acute gonococcal urethritis. Ofloxacin is alsoused for the treatment of urinary tract infections caused byGram-negative bacilli and for prostatitis caused by E. coli.Infections of the skin and soft tissues caused by staphylococci,streptococci, and Gram-negative bacilli may also betreated with ofloxacin.

Clinical Use

Complicated and uncomplicated infections of the urinary tract, chronic prostatitis
Uncomplicated urogenital and anorectal gonorrhea (single-dose), chancroid (3-day course), genital chlamydial infections (7-day course) Lower respiratory tract infections, including bronchopneumonia, community-acquired pneumonia (except pneumococcal pneumonia), acute bacterial exacerbations of chronic bronchitis (unless pneumococci are involved) and bronchiectasis
Enteric fever, including the chronic carrier state; gastroenteritis caused by enterotoxigenic Escherichia coli, Salmonella, Shigella and Campylobacter spp. Ocular infections (ophthalmic preparation)

Side effects

Untoward reactions havebeen described in 2.5–7.5% of patients, and are those common to the group: gastrointestinal tract disturbances, rashes, tendon rupture and insomnia. CNS effects rarely occur.

Enzyme inhibitor

This potent fluoroquinolone antibacterial (FWfree-acid = 361.37 g/mol; CAS 82419-36-1) inhibits DNA gyrase and is active against both Gram-positive and Gram-negative bacteria . (For the prototypical member of this antibiotic class, See Ciprofloxacin) Mode of Inhibitory Action: The drug’s bactericidal effect is mediated through the stabilization of a cleavable complex via a cooperative drug binding to a partially denatured DNA pocket created by DNA gyrase. The drug binds to supercoiled DNA in a manner similar to that to which it binds to the enzyme-DNA complex. The bacteria chromosome is composed mainly of double-stranded DNA, with 60-70 domains of supercoiling, each attached to an RNA core and organized by its own second echelon of supercoiling. DNA supercoiling is determined by DNA gyrase, an enzyme that introduces transient breaks into both DNA strands of each domain, removing ~400 helical turns before resealing the DNA and locking in the supercoiling. Ofloxacin blocks gyrase action by preferential binding to supercoiled DNA. The (S) -isomer, levofloxacin, has twice the antimicrobial activity of the (R) -isomer. Uptake of ofloxacin in moderately resistant strains is almost the same in the presence or absence of carbonyl cyanide m-chlorophenylhydrazone (CCCP), whereas in highly resistant strains, uptake increased when CCCP is added. Such findings suggest that resistance may depend, at least in part, to an energy-requiring drug export system. Target (s) : DNA gyrase, or DNA topoisomerase II; glutathione-disulfide reductase, inhibited by levofloxacin; medium-chain-fatty-acyl-CoA synthetase, or butyryl- CoA synthetase, or butyrate:CoA ligase.

Ofloxacin Preparation Products And Raw materials

Raw materials

Preparation Products


Ofloxacin Suppliers

Global( 309)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 541 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8409 58
Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
+86-21-57758967 sales@boylechem.com China 2214 55

View Lastest Price from Ofloxacin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Ofloxacin
82419-36-1
US $7.00 / kg 1kg 99% 100KG career henan chemical co
2018-09-25 Active Pharmaceutical Ingredients Ofloxacin quinolone antibacterial drugs CAS 82419-36-1
82419-36-1
US $1.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.

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