ChemicalBook >> CAS DataBase List >>5-Hydroxymethyluracil
5-Hydroxymethyluracil
- CAS No.
- 4433-40-3
- Chemical Name:
- 5-Hydroxymethyluracil
- Synonyms
- NSC 20901;AURORA KA-547;5-methyloluracil;α-HydroxythyMine;a-Hydroxythymine;uracil-5-methanol;TIMTEC-BB SBB000084;RARECHEM AH CK 0115;HYDROXYMETHYL URACIL;5-HYDROXYMETHYLURACIL
- CBNumber:
- CB7122987
- Molecular Formula:
- C5H6N2O3
- Molecular Weight:
- 142.11
- MDL Number:
- MFCD00056024
- MOL File:
- 4433-40-3.mol
- MSDS File:
- SDS
Last updated:2023-05-18 11:31:03
| Melting point | >300 °C(lit.) |
|---|---|
| Density | 1.401±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly, Heated) |
| pka | 8.46±0.10(Predicted) |
| form | Solid |
| color | White |
| Water Solubility | Soluble in water. (50 g/L ) at 20°C, DMSO, dimethyl formamide or 100% ethanol. |
| BRN | 125482 |
| InChI | InChI=1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10) |
| InChIKey | JDBGXEHEIRGOBU-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(CO)C(=O)N1 |
| CAS DataBase Reference | 4433-40-3(CAS DataBase Reference) |
| FDA UNII | 590TQ3GL34 |
| EPA Substance Registry System | 2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- (4433-40-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YR0513000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
5-Hydroxymethyluracil price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 852589 | 5-(Hydroxymethyl)uracil 97% | 4433-40-3 | 1g | $28.6 | 2024-03-01 | Buy |
| Alfa Aesar | L01682 | 5-(Hydroxymethyl)uracil, 98% | 4433-40-3 | 1g | $38.65 | 2024-03-01 | Buy |
| Alfa Aesar | L01682 | 5-(Hydroxymethyl)uracil, 98% | 4433-40-3 | 5g | $129.65 | 2024-03-01 | Buy |
| Cayman Chemical | 89360 | Hydroxymethyl Uracil ≥98% | 4433-40-3 | 250mg | $12 | 2024-03-01 | Buy |
| Cayman Chemical | 89360 | Hydroxymethyl Uracil | 4433-40-3 | 1000mg | $37 | 2024-03-01 | Buy |
5-Hydroxymethyluracil Chemical Properties,Uses,Production
Description
5-Hydroxymethyluracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction. It can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.
Chemical Properties
White Powder
Uses
5-Hydroxymethyluracil (cas# 4433-40-3) is a compound useful in organic synthesis.
Definition
ChEBI: 5-hydroxymethyluracil is a primary alcohol that is uracil bearing a hydroxymethyl substituent at the 5-position. It has a role as a human metabolite. It is a primary alcohol and a pyrimidone. It derives from a uracil.
Biosynthesis
5-Hydroxymethyluracil is produced by the enzyme thymine dioxygenase (EC 1.14.11.6) which catalyzes the chemical reaction thymine + 2-oxoglutarate + O2 <-> 5-hydroxymethyluracil + succinate + CO2.
The 3 substrates of this enzyme are thymine, 2-oxoglutarate, and O2, whereas its 3 products are 5-hydroxymethyluracil, succinate, and CO2. The 5hmU base can also be generated by oxidation/hydroxylation of thymine by the Ten-Eleven-Translocation (TET) proteins or result from deamination of 5hmC. DNA containing 5hmU has been reported to be more flexible and hydrophilic.
Biotechnological Production
5-Hydroxymethyluracil (5hmU) is a thymine base modification found in the genomic DNA of diverse organisms ranging from bacteriophages to mammals.
5-Hydroxymethyluracil Preparation Products And Raw materials
Raw materials
Potassium hydroxide
Formaldehyde
Hydrochloric acid
Uracil
4(3H)-Pyrimidinone, 2-(ethylthio)-5-(isocyanatomethyl)-
2,4(1H,3H)-Pyrimidinedione, dihydro-5,6-dihydroxy-
Propanamide, N-[(formylamino)carbonyl]-2-oxo-
5-(2-Hydroxy-ethoxymethyl)-1H-pyrimidine-2,4-dione
2,4(1H,3H)-Pyrimidinedione, 5-(aminomethyl)- (9CI)
2,4(1H,3H)-Pyrimidinedione, 5-(isocyanatomethyl)-
1of4
Preparation Products
Global( 225)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sense Chemicals (Shanghai) Co., Ltd. | +86-21-52751036; +8613818977689 | david.dai@sensechemicals.com | China | 224 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 2954 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
View Lastest Price from 5-Hydroxymethyluracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | 5-Hydroxymethyluracil
4433-40-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-05-15 | 5-hydroxymethyluracil
4433-40-3
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 5-Hydroxymethyluracil
4433-40-3
|
US $20.00 / KG | 10KG | 99% | 100kg | Career Henan Chemical Co |
-
- 5-Hydroxymethyluracil
4433-40-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-hydroxymethyluracil
4433-40-3
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-Hydroxymethyluracil
4433-40-3
- US $20.00 / KG
- 99%
- Career Henan Chemical Co
4433-40-3(5-Hydroxymethyluracil)Related Search:
3h)-pyrimidinedione,5-(hydroxymethyl)-4(1h
5-(hydroxymethyl)-uraci
RARECHEM AH CK 0115
TIMTEC-BB SBB000084
AURORA KA-547
HYDROXYMETHYL URACIL
5-HYDROXYMETHYLURACIL
5-(HYDROXYMETHYL)URACIL HYDRATE
5-HYDROXYMETHYLURACYL
5-(HYDROXYMETHYL)-2,4(1H,3H)PYRIMIDINEDIONE
2,4-DIHYDROXY-5-HYDROXYMETHYLPYRIMIDINE
2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)- (9CI)
5-(Hydroxymethyl)uracil,98%
5-(hydroxymethyl)pyrimidine-2,4-dione
uracil-5-methanol
5-(hydroxymethyl)-1H-pyrimidine-2,4-dione
5-methyloluracil
5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione, 5-(Hydroxymethyl)pyrimidine-2,4-diol
5-(hydroxyMethyl)pyriMidine-2
5-(HydroxyMethyl)-1,3-dihydropyriMidine-2,4-dione
NSC 20901
α-HydroxythyMine
5-(hydroxymethyl)pyrimidine-2,4-diol
5-(Hydroxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione|5-Hydroxymethyluracil
a-Hydroxythymine
2,4(1H,3H)-Pyrimidinedione, 5-(hydroxymethyl)-
4433-40-3
PYRIMIDINE
Nucleotides and Nucleosides
Nucleic acids
5-FOA
Bases & Related Reagents
Nucleotides
Building Blocks
Heterocyclic Building Blocks
Pyrimidines