Panitumumab
- CAS No.
- 339177-26-3
- Chemical Name:
- Panitumumab
- Synonyms
- Abenix;Abx-egf;Vectibix;Panitumumab;Abx-egf mab;Unii-6A901E312a;Panitumumab USP/EP/BP;Panitumumab (anti-EGFR);Research Grade Panitumumab(DHB86903);Research Grade Pintumomab (DHJ57401)
- CBNumber:
- CB81216039
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | Store at -20°C |
|---|---|
| NCI Dictionary of Cancer Terms | ABX-EGF; panitumumab; Vectibix |
| FDA UNII | 6A901E312A |
| NCI Drug Dictionary | panitumumab |
| ATC code | L01XC08 |
Panitumumab Chemical Properties,Uses,Production
Description
Panitumumab is a recombinant, fully human IgG2 kappa monoclonal antibody that is highly selective for the epidermal growth factor receptor (EGFR), and it is indicated for the treatment of EGFR-expressing, metastatic colorectal carcinoma (mCRC) with disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Overexpression of EGFR is detected in many human cancers, including those of the colon and rectum. Panitumumab blocks the binding of ligands such as epidermal growth factor (EGF) and transforming growth factor (TGF-a) to various EGFR-expressing cell lines, which results in inhibition of EGF-dependent tumor cell activation, induction of apoptosis, and decreased pro-inflammatory cytokine and vascular growth factor production. In vitro, panitumumab binds EGFR with high affinity (KD ? 50pM; IC50 ? 3 nM) in human cervical epidermal cell line A-431. .
Originator
Abgenix (US)
Uses
Antineoplastic.
brand name
Vectibix
Clinical Use
Monoclonal antibody:
Treatment of metastatic colorectal cancer
Drug interactions
Potentially hazardous interactions with other drugs
Cytotoxics: avoid with bevacizumab, fluorouracil,
irinotecan and oxaliplatin.
Folinic acid: avoid concomitant use.
Live vaccines: avoid concomitant use.
Metabolism
Saturable elimination mediated via reticuloendothelial system, and internalisation and degradation of EGFR.
Panitumumab Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 15926423062 | 422450190@qq.com | China | 10132 | 58 |
View Lastest Price from Panitumumab manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-03 | Panitumumab USP/EP/BP
339177-26-3
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-05-03 | Panitumumab
339177-26-3
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 800 ton | Shaanxi Dideu Medichem Co. Ltd |
-
- Panitumumab USP/EP/BP
339177-26-3
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Panitumumab
339177-26-3
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd