Ranolazine dihydrochloride
- CAS No.
- 95635-56-6
- Chemical Name:
- Ranolazine dihydrochloride
- Synonyms
- RS 43285;RS 43285-193;RANOLAZINE HCL;Ranolazine2Hcl;Ranolazine DiHCI;azine dihydrochL;RANOLAZINE DI HCL;Ranolazine and salt;Ranolazine dihydroch;(±)-Ranolazine-d8 2HCl
- CBNumber:
- CB8195173
- Molecular Formula:
- C24H35Cl2N3O4
- Molecular Weight:
- 500.46
- MDL Number:
- MFCD03788770
- MOL File:
- 95635-56-6.mol
- MSDS File:
- SDS
Melting point | 222-229.5 °C(lit.) |
---|---|
storage temp. | Desiccate at RT |
solubility | H2O: 10 mg/mL, soluble |
form | solid |
color | off-white |
Merck | 14,8111 |
Stability | Hygroscopic |
CAS DataBase Reference | 95635-56-6(CAS DataBase Reference) |
FDA UNII | F71253DJUN |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
Safety Statements | 22-24/25 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | TK7845370 | |||||||||
HS Code | 29335990 | |||||||||
NFPA 704 |
|
Ranolazine dihydrochloride price More Price(35)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | R6152 | Ranolazine dihydrochloride ≥98% (HPLC), powder | 95635-56-6 | 100mg | $256 | 2024-03-01 | Buy |
Sigma-Aldrich | R6152 | Ranolazine dihydrochloride ≥98% (HPLC), powder | 95635-56-6 | 500mg | $918 | 2024-03-01 | Buy |
TCI Chemical | R0112 | Ranolazine Dihydrochloride >98.0%(HPLC)(T) | 95635-56-6 | 1g | $194 | 2024-03-01 | Buy |
TCI Chemical | R0112 | Ranolazine Dihydrochloride >98.0%(HPLC)(T) | 95635-56-6 | 5g | $581 | 2024-03-01 | Buy |
Cayman Chemical | 15604 | Ranolazine (hydrochloride) ≥98% | 95635-56-6 | 50mg | $81 | 2024-03-01 | Buy |
Ranolazine dihydrochloride Chemical Properties,Uses,Production
Description
Ranolazine is a piperazine derivative with cardioprotective activity. It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively). Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively). In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits. Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .
Chemical Properties
White Crystalline Powder
Uses
treatment of angina and congestive heart failure
Uses
Ranolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.
Biological Activity
Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I Na and I Kr currents.
Biochem/physiol Actions
Ranolazine is a derivative of anti-ischemic piperazine and acts as sodium (Na+)-current inhibitor. It has the potential to treat diastolic heart failure and helps in ameliorating myocardial diastolic function.
storage
Desiccate at RT
Ranolazine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hebei Jimi Trading Co., Ltd. | +86 319 5273535 | bestoneforyou@sina.com | CHINA | 288 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 9205 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
View Lastest Price from Ranolazine dihydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-11-20 | Ranolazine Dihydrochloride
95635-56-6
|
US $10.00 / Kg/Bag | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd | ||
2021-07-02 | Ranolazine dihydrochloride
95635-56-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2019-07-06 | Ranolazine dihydrochloride
95635-56-6
|
US $100.00 / KG | 1KG | 99% | Customized | Career Henan Chemical Co |
- Ranolazine Dihydrochloride
95635-56-6
- US $10.00 / Kg/Bag
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
- Ranolazine dihydrochloride
95635-56-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Ranolazine dihydrochloride
95635-56-6
- US $100.00 / KG
- 99%
- Career Henan Chemical Co