Emedastine
- CAS No.
- 87233-61-2
- Chemical Name:
- Emedastine
- Synonyms
- Emestine;EMEDASTINE;Emedastine impurity F;Emedastinc Impurity C;Emedastine Impurity C;Emedastine Impurity 14;Emedastine, 10 mM in DMSO;1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)benzimidazole;1-(2-Ethoxyethyl)-2-(4-methyl-1,4-diazepan-1-yl)-1H-benzimidazole;1-(2-ethoxyethyl)-2-(4-Methyl-1,4-diazepan-1-yl)-1H-1,3-benzodiazole
- CBNumber:
- CB8728076
- Molecular Formula:
- C17H26N4O
- Molecular Weight:
- 302.41
- MDL Number:
- MFCD00865647
- MOL File:
- 87233-61-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Emedastine ≥98.0% | CS-0028590 | 5mg | $350 |
| EMEDASTINE 95.00% | API0009136 | 5MG | $496.67 |
| Emedastine ≥98.0% | CS-0028590 | 10mg | $550 |
| Emedastine ≥98.0% | CS-0028590 | 50mg | $1650 |
| Emedastine ≥98.0% | CS-0028590 | 100mg | $2250 |
| More product size | |||
| Boiling point | 446.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 125 mg/mL (413.35 mM); Ethanol: 100 mg/mL (330.68 mM) |
| pka | 8.86±0.10(Predicted) |
| form | Viscous Liquid |
| color | Yellow to brown |
| CAS DataBase Reference | 87233-61-2(CAS DataBase Reference) |
| FDA UNII | 9J1H7Y9OJV |
| ATC code | S01GX06 |
Emedastine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0028590 | Emedastine ≥98.0% | 87233-61-2 | 5mg | $350 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0009136 | EMEDASTINE 95.00% | 87233-61-2 | 5MG | $496.67 | 2021-12-16 | Buy |
| ChemScene | CS-0028590 | Emedastine ≥98.0% | 87233-61-2 | 10mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0028590 | Emedastine ≥98.0% | 87233-61-2 | 50mg | $1650 | 2021-12-16 | Buy |
| ChemScene | CS-0028590 | Emedastine ≥98.0% | 87233-61-2 | 100mg | $2250 | 2021-12-16 | Buy |
Emedastine Chemical Properties,Uses,Production
Uses
Antihistaminic, H1-receptor; asthma prophylactic; anti-allergic.
Definition
ChEBI: 1-Methyl-1,4-diazepane in which the hydrogen attached to the nitrogen at position 4 is substituted by a 1-(2-ethoxyethyl)-1H-benzimidazol-2-yl group. A relatively selective histamine H1 antagonist, it is used as the ifumatate salt for allergic rhinitis, urticaria, and pruritic skin disorders, and in eyedrops for the symptomatic relief of allergic conjuntivitis.
brand name
Emadine (Alcon).
Clinical Use
Emedastine also is a newer antihistamine used topically in the eye for conjunctivitis. It has very high H1 receptor selectivity characteristics, and it is structurally related to the benzimidazoles, such as astemizole. Inhibition of mast cell release of inflammatory mediators has been noted.
in vivo
Emedastine (0.03, 0.1, 0.3 mg/kg; orally; pretreatment of 30 min) significantly suppresses histamine-induced scratching with 0.1 and 0.3 mg/kg but not 0.03 mg/kg[3].
Pretreatment with Emedastine (0.03, 0.1, 0.3 mg/kg; orally) significantly inhibits the scratching induced by substance P and leukotriene B[3].
Emedastine (0.3 mg/kg, p.o.) produces significant inhibition of passive peritoneal anaphylaxis in guinea-pigs[2].
Emedastine inhibits histamine-induced contractions of isolated ileum (IC50=6.1 nM)[2].
| Animal Model: | Male ICR mice 5-6 weeks of age[3] |
| Dosage: | 0.03, 0.1, 0.3 mg/kg |
| Administration: | Orally; 30 min before pruritogen injection |
| Result: | Significantly suppressed histamine-induced scratching with pretreatment of 0.1 and 0.3 mg/kg. |
IC 50
H1 Receptor: 1.3 nM (Ki); H2 Receptor: 49067 nM (Ki); H3 Receptor: 12430 nM (Ki)
Emedastine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29799 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
View Lastest Price from Emedastine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-04 | Emedastine
87233-61-2
|
US $31.00-117.00 / mg | 97.76% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-15 | Emedastine
87233-61-2
|
US $1.00 / g | 1g | 95-99% | 1ton | Career Henan Chemical Co |
-
- Emedastine
87233-61-2
- US $31.00-117.00 / mg
- 97.76%
- TargetMol Chemicals Inc.
-
- Emedastine
87233-61-2
- US $1.00 / g
- 95-99%
- Career Henan Chemical Co
