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Citraconic anhydride

Chemical Name:
Citraconic anhydride
CTA;2,5-Furandione, 3-Methyl-;3-Methylmaleic anhydride;3-methyl-furan-2,5-dione;alpha-methylmaleicanhydride;CITRACONIC ANHYDRIDE;methyl-maleicanhydrid;3-methyl-5-furandione;METHYLMALEIC ANHYDRIDE;CitraconicAnhydride>
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Modify Date:2022-11-08 16:46:48

Citraconic anhydride Properties

Melting point 6-10 °C (lit.)
Boiling point 213-214 °C (lit.)
Density 1.247 g/mL at 25 °C (lit.)
vapor density 4 (vs air)
refractive index n20/D 1.471(lit.)
Flash point 215 °F
storage temp. Inert atmosphere,2-8°C
form Liquid
color Clear colorless to very slightly yellow
Water Solubility decomposes
Sensitive Moisture Sensitive
BRN 1835
CAS DataBase Reference 616-02-4(CAS DataBase Reference)
EWG's Food Scores 1
NCI Dictionary of Cancer Terms CTA
NIST Chemistry Reference 2,5-Furandione, 3-methyl-(616-02-4)
EPA Substance Registry System 2,5-Furandione, 3-methyl- (616-02-4)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
Signal word  Danger
Hazard statements  H314-H317-H334
Precautionary statements  P261-P272-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T
Risk Statements  23/24/25-36/37/38-42/43-34-24
Safety Statements  26-36/37/39-45-28A-23-36/37
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
RTECS  GE6825000
HazardClass  6.1
PackingGroup  III
HS Code  29171990
NFPA 704
3 1

Citraconic anhydride price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 125318 Citraconic anhydride 98% 616-02-4 25g $38.7 2022-05-15 Buy
Sigma-Aldrich 125318 Citraconic anhydride 98% 616-02-4 100g $97.3 2022-05-15 Buy
TCI Chemical M0365 Citraconic Anhydride >98.0%(GC) 616-02-4 25g $21 2022-04-27 Buy
TCI Chemical M0365 Citraconic Anhydride >98.0%(GC) 616-02-4 100g $54 2022-04-27 Buy
Alfa Aesar L05238 Citraconic anhydride, 98% 616-02-4 25g $29.8 2022-04-27 Buy
Product number Packaging Price Buy
125318 25g $38.7 Buy
125318 100g $97.3 Buy
M0365 25g $21 Buy
M0365 100g $54 Buy
L05238 25g $29.8 Buy

Citraconic anhydride Chemical Properties,Uses,Production

Chemical Properties

clear colorless to very slightly yellow liquid


Versatile reagent used for the synthesis of maleimides, bicyclic pyrrolidines, and co- and terpolymers, as well as for the protection of N-terminal amino acids.


Citraconic anhydride is used as a monomer for specialty unsaturated polyester resins. It is used to prepare bicyclic pyrrolidines, maleimides and co- and terpolymers. It is also used for the protection of N-terminal amino acids. Further, it is involved in the preparation of clothing ping acid and its amide. In addition to this, it is selectively used for the isolation of histidyl peptides.


Reagent for alkalies, alcohols, and amines.

Flammability and Explosibility


Purification Methods

Possible contamination is from the acid formed by hydrolysis. If the IR has OH bands, then reflux with Ac2O for 30minutes, evaporate, then distil the residue in a vacuum, otherwise distil in a vacuum. Store in a dry atmosphere. [Vaughan & Andersen J Am Chem Soc 77 6702 1955, Vaughan & Andersen J Org Chem 21 680 1956, Beilstein 17 H 440, 17 I 234, 17 II 448, 17 III/IV 5912, 17/11 V 65.]

Synthesis of Citraconic anhydride from Itaconic acid
Global( 248)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 29789 60
Henan Tianfu Chemical Co.,Ltd.
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career henan chemical co
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Hebei Guanlang Biotechnology Co., Ltd.
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Alchem Pharmtech,Inc.
8485655694 United States 63711 58
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Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 CHINA 13170 58

View Lastest Price from Citraconic anhydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Citraconic anhydride pictures 2021-07-13 Citraconic anhydride
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Citraconic anhydride pictures 2021-07-10 Citraconic anhydride
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Citraconic anhydride pictures 2021-04-27 Citraconic anhydride
US $1.00 / PCS 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
Anhydrid kyseliny citrakonove anhydridkyselinycitrakonove Citraconic acid anhydride citraconicacidanhydride Maleic anhydride, methyl- methyl-maleicacidanhydride methyl-maleicanhydrid Monomethylmaleic anhydride monomethylmaleicanhydride Citraconicanhydride,98% 3-methyl-2,5-pentanedione lpha-methylmaleic anhydride cis-Methylbutenedioic anhydride 2-METHYLMALEIC ANHYDRIDE CITRACONIC ANHYDRIDE METHYLMALEIC ANHYDRIDE 3-Methylfuran-2,5-dione, 2-Methylmaleic anhydride Citraconic anhydride, 98% 100GR Citraconic anhydride, 98% 250GR Citraconic anhydride 98% Citraconic Anhydride, 98.0%(GC) 2,5-Furanedione, 3-methyl 3-Methyl-2,5-furandione 3-methyl-5-furandione 3-methylmaleicanhydride alpha-Methylmaleic anhydride CitraconicAnhydride> alpha-methylmaleicanhydride CTA 3-methyl-furan-2,5-dione 3-Methylmaleic anhydride 2,5-Furandione, 3-Methyl- 616-02-4 516-02-4 C5H4O3OCO Carbonyl Compounds Carboxylic Acid Anhydrides BioChemical Building Blocks Specific Amino Acid Modification Reagents for lysine modification Proteomics Proteomics and Protein Expression Protein Modification Organic Building Blocks Anhydride Monomers Monomers Polymer Science Carbonyl Compounds Carboxylic Acid Anhydrides Organic Building Blocks Rubber & Plastic Auxiliary Agent