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クロロ酢酸

クロロ酢酸 化学構造式
79-11-8
CAS番号.
79-11-8
化学名:
クロロ酢酸
别名:
クロロ酢酸;モノクロロ酢酸;クロロ酢酸標準原液;モノクロル酢酸;モノクロロ酢酸(クロロ酢酸);クロロ酢酸, 1000 µg/mL in MtBE;モノクロロ酢酸, 60 µg/mL in MtBE;クロロエタン酸
英語化学名:
Chloroacetic acid
英語别名:
MCA;NSC 142;CH2ClCOOH;NSC 42970;NCI-C60231;chloracetic;ATLAS SOMON;Chloroacetic;CROPTEX STEEL;Chloressigsure
CBNumber:
CB2854397
化学式:
C2H3ClO2
分子量:
94.5
MOL File:
79-11-8.mol

クロロ酢酸 物理性質

融点 :
60-63 °C (lit.)
沸点 :
189 °C (lit.)
比重(密度) :
1.58
蒸気密度:
3.26 (vs air)
蒸気圧:
0.75 mm Hg ( 20 °C)
屈折率 :
1.4330
闪点 :
126°C
貯蔵温度 :
Store below +30°C.
溶解性:
Soluble in methanol, acetone, diethyl ether, benzene, chloroform and ethanol.
酸解離定数(Pka):
2.85(at 25℃)
外見 :
Liquid
色:
White
臭い (Odor):
Penetrating, burning odor
酸塩基指示薬変色域(pH):
< 1 at 800 g/l at 20 °C
爆発限界(explosive limit):
8%
水溶解度 :
SOLUBLE
Sensitive :
Hygroscopic
Merck :
14,2112
BRN :
605438
Specific Activity:
5-10 Ci/mmol
Solvent:
Sterile water in sealed ampoule
Concentration:
1 mCi/ml
安定性::
Stable. Deliquescent. Incompatible with strong bases, alkalies, most common metals, strong oxidizing agents.
CAS データベース:
79-11-8(CAS DataBase Reference)
NISTの化学物質情報:
Acetic acid, chloro-(79-11-8)
EPAの化学物質情報:
Chloroacetic acid (79-11-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T,N,Xi,F
Rフレーズ  25-34-50-40-36/37/38-23/24/25-38
Sフレーズ  23-37-45-61-36-26-16-63-36/37/39
RIDADR  UN 1751 6.1/PG 2
WGK Germany  2
RTECS 番号 AF8575000
3
TSCA  Yes
国連危険物分類  6.1
容器等級  II
HSコード  29154000
有毒物質データの 79-11-8(Hazardous Substances Data)
消防法 危-4-1-II
化審法 優先評価化学物質
安衛法 57,57-2
PRTR法 第1種指定化学物質
毒劇物取締法 II
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 P264, P270, P301+P310, P321, P330,P405, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H314 重篤な皮膚の薬傷?眼の損傷 皮膚腐食性/刺激性 1A, B, C 危険 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H331 吸入すると有毒 急性毒性、吸入 3 危険 P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H400 水生生物に強い毒性 水生環境有害性、急性毒性 1 警告 P273, P391, P501
注意書き
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P405 施錠して保管すること。

クロロ酢酸 価格 もっと(15)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
キシダ化学株式会社(Kishida) 000-51205
Chloroacetic acid
79-11-8 500g ¥2200 2021-03-22 購入
キシダ化学株式会社(Kishida) 000-51202
Chloroacetic acid
79-11-8 25g ¥1800 2021-03-22 購入
林純薬工業株式会社 03002042 ≧99%
Chloroacetic acidMonochloroacetic acidモノクロロ酢酸 ≧99%
79-11-8 25g ¥1300 2021-03-22 購入
純正化学株式会社 28220-1201
Chloroacetic acid;Monochloroacetic acid
79-11-8 500g ¥1800 2021-03-22 購入
純正化学株式会社 28220-0301
Chloroacetic acid;Monochloroacetic acid
79-11-8 500g ¥2200 2021-03-22 購入

クロロ酢酸 MSDS


MCA

クロロ酢酸 化学特性,用途語,生産方法

外観

白色, 結晶及び塊

定義

本品は、次の化学式で表される有機化合物である。

溶解性

水と混和, エタノール, エーテルに易溶。水にきわめて溶けやすく、エタノール及びジエチルエーテルに溶けやすい。水にきわめて溶けやすく、エタノール及びジエチルエーテルに溶けやすい。

解説

酢酸の塩素置換体に相当し,その程度によって異なる3種類のものがある.一般にはモノクロロ酢酸をさす.【Ⅰ】モノクロロ酢酸:C2H3ClO2(94.50).CH2ClCOOH.酢酸を少量の硫黄,ヨウ素などの存在下で塩素化するか,トリクロロエテンを硫酸で処理すると得られる.無色の潮解性結晶.d20201.58.3種類の形があり,それぞれの融点はα形:63 ℃,β形:55~56 ℃,γ形:50 ℃.沸点189 ℃,104 ℃(2.66 kPa).水,エタノール,ベンゼン,クロロホルム,エーテルに可溶.水溶液は酢酸より強酸である.pKa 2.85,Ka 1.55×10-2(25 ℃).アンモニアと反応してグリシンに,またシアン化カリウムと反応してシアン酢酸になる.種々の有機合成の原料になる.[CAS 79-11-8]【Ⅱ】ジクロロ酢酸:C2H2Cl2O2(128.95).CHCl2COOH.モノクロロ酢酸を塩素化すると得られる.液体.融点9.7 ℃,沸点193~194 ℃,102 ℃(2.6 kPa).d204"1.563.水,エタノール,エーテルに易溶.加水分解するとグリオキシル酸になる.刺激臭を有する.[CAS 79-43-6]【Ⅲ】トリクロロ酢酸:C2HCl3O2(163.39).CCl3COOH.クロラールを硝酸酸化するか,ジクロロ酢酸をさらに塩素化すると得られる.無色の潮解性結晶.融点57~58 ℃,沸点197 ℃,142 ℃(3.3 kPa).d204"1.629.水,エタノール,エーテルに易溶.モノクロロ酢酸,ジクロロ酢酸より強酸である.pH 1.2.希アルカリで加水分解されてクロロホルムと二酸化炭素になる.また,濃アルカリではギ酸になる.腐食剤,角質溶解剤などのほか,生体のリン酸化合物,タンパク質,脂質などの分画分析に用いられる.強い腐食性を有する.[CAS 76-03-9] 三者とも皮膚,粘膜などをおかすのでとくに注意が必要である.
森北出版「化学辞典(第2版)

用途

除草剤、医薬品原料、有機合成用

用途

カルボキシメチルセルロース原料、2,4-ジシクロフェノキシ酢酸原料、チオグリコール酸及び両性界面活性剤原料 (NITE初期リスク評価書)

用途

有機合成原料。

用途

有機合成原料(医薬、農薬、可塑剤、香料等)。

化粧品の成分用途

pH調整剤、剥離剤

効能

腐食剤

使用上の注意

極めて潮解性が強く液化しやすい。腐食性大。

説明

Chloroacetic acid (CAA) is a monohalogenated acetic acid (m-HAA) that is used as a photosensitizing agent and in industrial synthesis of certain organic chemicals such as indigoid dyes. The m-HAAs are a major class of drinking water disinfection by-products during chlorination of drinking water.

化学的特性

Chloroacetic acid is a colorless to white crystalline solid. It has a strong vinegar-like odor and an Odor Threshold of 0.15 milligram per cubic meter.

化学的特性

colourless or white crystals

使用

Herbicide, preservative, bacteriostat, intermediate in production of carboxymethylcellulose; ethyl chloroacetate, glycine, synthetic caffeine, sarcosine, thioglycolic acid, EDTA, 2,4-D, 2,4,5-T.

使用

Chloroacetic acid behaves as a very strong monobasic acid and is used as a strong acid catalyst for diverse reactions. The Cl function can be displaced in base-catalyzed reactions.

使用

CAA is one of these agents used in the topical treatment of warts in most European countries and also as an herbicidal agent and a bleaching agent for silkworm cocoons. It can be found in wines and beers using static headspace extraction coupled with gas chromatography–mass spectrometry. CCA is the main toxic metabolite of vinyl chloride. CAA and volatile organochlorines are suspected to contribute to forest dieback and stratospheric ozone destruction.

定義

A colorless crystalline solid made by substituting one of the hydrogen atoms of the methyl group of ethanoic acid with chlorine, using red phosphorus. It is a stronger acid than ethanoic acid because of the electron-withdrawing effect of the chlorine atom. Dichloroethanoic acid (dichloroacetic acid, CHCl2COOH) and trichloroethanoic acid (trichloroacetic acid,CCl3COOH) are made in the same way. The acid strength increases with the number of chlorine atoms present.

調製方法

Chloroacetic acid can be synthesized by the radical chlorination of acetic acid, treatment of trichloroethylene with concentrated H2SO4, oxidation of 1,2-dichloroethane or chloroacetaldehyde, amine displacement from glycine, or chlorination of ketene.

定義

ChEBI: A chlorocarboxylic acid that is acetic acid carrying a 2-chloro substituent.

一般的な説明

Chloroacetic acid, solution is a colorless solution of the white crystalline solid. The acid concentration can be up to 80%.It is used in manufacturing dyes and in medicine. Chloroacetic acid is toxic by inhalation, ingestion and skin contact. Chloroacetic acid is corrosive to metals and tissue. Chloroacetic acid is used as an herbicide, preservative and bacteriostat.

空気と水の反応

Water soluble.

反応プロフィール

These organic compounds donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Chloroacetic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

危険性

Use in foods prohibited by FDA. Irritating and corrosive to skin. Upper respiratory tract irritant. Questionable carcinogen.

健康ハザード

Inhalation causes mucous membrane irritation. Contact with liquid causes severe irritation and burns of the eyes and irritation and burns of skin. Ingestion causes burns of mouth and stomach.

火災危険

Special Hazards of Combustion Products: Toxic gases, such as hydrogen chloride, phosgene and carbon monoxide, may be generated.

安全性プロファイル

Poison by ingestion, inhalation, subcutaneous, and intravenous routes. A corrosive skin, eye, and mucous membrane irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible liquid when exposed to heat or flame. To fight fire, use water spray, fog, mist, dry chemical, foam. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES.

職業ばく露

This haloacetic acid can be a byproduct of drinking water disinfection and may increase the risk of cancer. Monochloracetic acid is used primarily as a chemical intermediate in the synthesis of sodium carboxymethyl cellulose; and such other diverse substances as ethyl chloroacetate, glycine, synthetic caffeine, sarcosine, thioglycolic acid, and various dyes. Hence, workers in these areas are affected. It is also used as an herbicide. Therefore, formulators and applicators of such herbicides are affected.

環境運命予測

CCA by inhibition of the pyruvate-dehydrogenase, aconitase, and a-ketoglutarate dehydrogenase that contribute in tricarboxylic acid cycle and also inhibition of glyceraldehyde- 3-phosphate dehydrogenase can impair production of cellular energy and conversion to anaerobic glycolysis, resulting in increasing acidosis with accumulation of glycolic acid, oxalate, and lactate production. CCA can also affect cellular components via sulfhydryl groups. Both of these effects may contribute to central nervous system (CNS), cardiovascular, renal, and hepatic effects. The metabolites glycolic acid and oxalate may contribute to CNS and renal toxicity (myoglobin and oxalate precipitation in the tubuli). Binding of calcium to oxalates probably causes the hypocalcemia, but hypocalcemia can be secondary to rhabdomyolysis. CAA by reduction of cellular glutathione can cause oxidative stress. Inhibition of mitochondrial aconitase causes hypoglycemia.

輸送方法

UN1750 (liquid) & UN1751 (solid) Chloroacetic acid, solid or liquid, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive material.

純化方法

Crystallise the acid from CHCl3, CCl4, *benzene or water. Dry it over P2O5 or conc H2SO4 in a vacuum desiccator. Further purification is by distillation from MgSO4, and by fractional crystallisation from the melt. Store it under vacuum or under dry N2. [Bernasconi et al. J Am Chem Soc 107 3621 1985, Beilstein 2 IV 474.]

Toxicity evaluation

Occupational exposure to CAA can occur through inhalation and dermal contact with this compound at workplaces where it is produced or used. The general population can be exposed to CAA via ingestion of chlorinated or chloraminated drinking water.
The atmospheric photochemical oxidation of some volatile organochlorine compounds is one source of CAAs in the environment. CAA can be generated during water disinfection processes and during metabolic detoxification of industrial solvents such as trichloroethylene.

不和合性

Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water, and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates, and dithionites (releasing hydrogen sulfate and oxides of sulfur). The solution in water is a strong acid. Contact with strong oxidizers, strong bases; and strong reducing agents such as hydrides can cause violent reactions. Chloracetic acid decomposes on heating, producing toxic and corrosive hydrogen chloride, phosgene, and carbon monoxide gases. Attacks metals in the presence of moisture.

廃棄物の処理

Incineration, preferably after mixing with another combustible fuel; care must be exercised to assure complete combustion to prevent the formation of phosgene; an acid scrubber is necessary to remove the halo acids produced.

クロロ酢酸 上流と下流の製品情報

原材料

準備製品


クロロ酢酸 生産企業

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名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度

79-11-8(クロロ酢酸)キーワード:


  • 79-11-8
  • acidechloroacetique
  • acidechloroacetique(french)
  • acidemonochloracetique
  • acidemonochloracetique(french)
  • acidemonochloracetique(solide)
  • acidemonochloracetique(solutions)
  • Acidomonocloroacetico
  • alpha-Chloroacetic acid
  • alpha-chloroaceticacid
  • Carboxymethylchloride
  • CH2ClCOOH
  • chloracetic
  • Chloracetic acid
  • chloraceticacid
  • Chloroacetic
  • chloro-aceticaci
  • chloroaceticacid,liquid
  • chloroaceticacid,solid
  • chloroaceticacid,solid(dot)
  • Kyselina chloroctova
  • kyselinachloroctova
  • Monochloorazijnzuur
  • Monochloracetic acid
  • Monochloracetic acidacide monochloracetique
  • monochloraceticacid
  • Monochloressigsaeure
  • monochloroaceticacid(non-specificname)
  • monochloroaceticacidsolid
  • monochloroaceticacidsolution(dot)
  • Chloroacetic acid, ACS, 99+%
  • クロロ酢酸
  • モノクロロ酢酸
  • クロロ酢酸標準原液
  • モノクロル酢酸
  • モノクロロ酢酸(クロロ酢酸)
  • クロロ酢酸, 1000 µg/mL in MtBE
  • モノクロロ酢酸, 60 µg/mL in MtBE
  • クロロエタン酸
  • 構造分類
  • ω-クロロカルボン酸
  • ω-官能性アルカノール, カルボン酸, アミン & ハライド
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