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라우르산

라우르산
라우르산 구조식 이미지
카스 번호:
143-07-7
한글명:
라우르산
동의어(한글):
라우르산;도데카노익산;라우릭산;라우릭애씨드;도데칸산;1-운데케인카복실산;n-도데칸산;데다콘산;도데실산;도데칸 산;도데코 산;도데크산;듀오-디시클릭 산;라우로스테아르 산;로로스테아르산;로르산;하이드로폴 산 1255
상품명:
Lauric acid
동의어(영문):
C12;C-1297;NAA122;NAA312;12 acid;Emery651;NSC 5026;LunacL70;LunacL98;Emery 650
CBNumber:
CB0357278
분자식:
C12H24O2
포뮬러 무게:
200.32
MOL 파일:
143-07-7.mol

라우르산 속성

녹는점
44-46 °C (lit.)
끓는 점
225 °C/100 mmHg (lit.)
밀도
0.883 g/mL at 25 °C (lit.)
증기압
1 mm Hg ( 121 °C)
굴절률
1.4304
FEMA
2614 | LAURIC ACID
인화점
>230 °F
저장 조건
2-8°C
용해도
4.81mg/l
물리적 상태
Crystalline Powder of Flakes
산도 계수 (pKa)
pKa 4.92(H2O,t =25.0) (Uncertain)
Specific Gravity
0.883
색상
White
폭발한계
0.6%(V)
수용성
insoluble
최대 파장(λmax)
207nm(MeOH)(lit.)
Merck
14,5384
JECFA Number
111
BRN
1099477
안정성
Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents.
InChIKey
POULHZVOKOAJMA-UHFFFAOYSA-N
CAS 데이터베이스
143-07-7(CAS DataBase Reference)
NIST
Dodecanoic acid(143-07-7)
EPA
Lauric acid (143-07-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/38-41-36/37/38
안전지침서 37/39-26-39-36-36/39-24/25
WGK 독일 1
RTECS 번호 OE9800000
자연 발화 온도 250 °C
TSCA Yes
HS 번호 29159010
유해 물질 데이터 143-07-7(Hazardous Substances Data)
독성 LD50 i.v. in mice: 131 ±5.7 mg/kg (Or, Wretlind)
기존화학 물질 KE-12855
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H401 수생생물에 유독함 수생 환경유해성 물질 - 급성 구분 2 P273, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P337+P313 눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

라우르산 MSDS


Dodecanoic acid

라우르산 C화학적 특성, 용도, 생산

물성

도데실산 또는 도데칸산이라고도 한다. 백색 침상결정(針狀結晶) 또는 분말 로 녹는점 43.5 ℃, 끓는점 298.9 ℃, 비중 0.8690(50 ℃)이다. 글리세리드로서 야자유 속에 존재한 다. 물에는 녹지 않지만, 벤젠 등에는 잘 녹는다.

용도

명칭은 월계수의 학명에서 유래되었다. 세제 ·표 면활성제의 원료로 사용하는 라우릴알코올의 원료가 된다.

개요

Lauric acid ( systematically: dodecanoic acid ), the saturated fatty acid with a 12-carbon atom chain, thus falling into the medium chain fatty acids, is a white, powdery solid with a faint odor of bay oil or soap.

화학적 성질

Like many other fatty acids, lauric acid is inexpensive, has a long shelf-life, and is non-toxic and safe to handle. It is mainly used for the production of soaps and cosmetics. For these purposes, lauric acid is neutralized with sodium hydroxide to give sodium laurate, which is a soap. Most commonly, sodium laurate is obtained by saponification of various oils, such as coconut oil. These precursors give mixtures of sodium laurate and other soaps.

화학적 성질

Laurie acid has a fatty odor.

화학적 성질

Lauric acid has a fatty odor. It is a common constituent of most diets; large doses may produce gastrointestinal upset

화학적 성질

white solid with a faint odour of bay oil

화학적 성질

Lauric acid occurs as a white crystalline powder with a slight odor of bay oil.

출처

Lauric acid, as a component of triglycerides, comprises about half of the fatty acid content in coconut oil, laurel oil, and in palm kernel oil (not to be confused with palm oil) , Otherwise it is relatively uncommon. It is also found in human breast milk ( 6.2 % of total fat), cow's milk (2.9%), and goat's milk (3.1 %).

용도

Given its foaming properties, the derivatives of lauric acid (h-dodecanoic acid) are widely used as a base in the manufacture of soaps, detergents, and lauryl alcohol. Lauric acid is a common constituent of vegetable fats, especially coconut oil and laurel oil. It may have a synergistic effect in a formula to help fight against mircoorganisms. It is a mild irritant but not a sensitizer, and some sources cite it as comedogenic.

용도

Lauric Acid is a fatty acid obtained from coconut oil and other veg- etable fats. it is practically insoluble in water but is soluble in alco- hol, chloroform, and ether. it functions as a lubricant, binder, and defoaming agent.

용도

Intermediates of Liquid Crystals

정의

ChEBI: A straight-chain, twelve-carbon medium-chain saturated fatty acid with strong bactericidal properties; the main fatty acid in coconut oil and palm kernel oil.

생산 방법

Lauric acid is a fatty carboxylic acid isolated from vegetable and animal fats or oils. For example, coconut oil and palm kernel oil both contain high proportions of lauric acid. Isolation from natural fats and oils involves hydrolysis, separation of the fatty acids, hydrogenation to convert unsaturated fatty acids to saturated acids, and finally distillation of the specific fatty acid of interest.

정의

A white crystalline carboxylic acid, used as a plasticizer and for making detergents and soaps. Its glycerides occur naturally in coconut and palm oils.

Aroma threshold values

Aroma characteristics at 1.0%: fatty, creamy, cheeselike, candle waxy with egglike richness

Taste threshold values

Taste characteristics at 5 ppm: waxy,fatty and oily, tallowlike, creamy and dairylike with a coating mouthfeel

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 5931, 1991 DOI: 10.1016/S0040-4039(00)79429-9

일반 설명

White solid with a slight odor of bay oil.

공기와 물의 반응

Insoluble in water.

반응 프로필

Lauric acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Lauric acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. Lauric acid can react with oxidizing materials.

건강위험

May be harmful by inhalation, ingestion or skin absorption. Vapor or mist is irritating to eyes, mucous membrane and upper respiratory tract. Causes eye and skin irritation.

화재위험

Behavior in Fire: May cause dust explosion.

Pharmaceutical Applications

pharmaceutical applications it has also been examined for use as an enhancer for topical penetration and transdermal absorption, rectal absorption, buccal delivery,(14) and intestinal absorption. It is also useful for stabilizing oil-in-water emulsions. Lauric acid has also been evaluated for use in aerosol formulations.

Safety

Lauric acid is widely used in cosmetic preparations, in the manufacture of food-grade additives, and in pharmaceutical formulations. General exposure to lauric acid occurs through the consumption of food and through dermal contact with cosmetics, soaps, and detergent products. Lauric acid is toxic when administered intravenously.
Occupational exposure may cause local irritation of eyes, nose, throat, and respiratory tract, although lauric acid is considered safe and nonirritating for use in cosmetics. No toxicological effects were observed when lauric acid was administered to rats at 35% of the diet for 2 years. Acute exposure tests in rabbits indicate mild irritation. After subcutaneous injection into mice, lauric acid was shown to be noncarcinogenic.
LD50 (mouse, IV): 0.13 g/kg
LD50 (rat, oral): 12 g/kg

Chemical Synthesis

Produced from synthetic lauryl alcohol

Carcinogenicity

Lauric acid was not carcinogenic in the BALB/c:CFW mouse after repeated subcutaneous injections. Lauric acid applied twice weekly for 20 weeks did not promote tumors in mice initiated with 9,10- dimethyl-1,2-benzanthracene. After more extended application (daily, 6 days/week, for 31 weeks), lauric acid caused an increase in skin papillomas, but no histologically malignant tumors were found. Lauric acid was not carcinogenic in rats after exposure in the diet to 35% lauric acid for 2 years.

저장

Lauric acid is stable at normal temperatures and should be stored in a cool, dry place. Avoid sources of ignition and contact with incompatible materials.

Purification Methods

Distil the acid in a vacuum. Also crystallise it from absolute EtOH, or from acetone at -25o. Alternatively, purify it via its methyl ester (b 140.0o/15mm), as described for capric acid. It has also been purified by zone melting. [cf Beilstein 1 III 2913.]

비 호환성

Lauric acid is incompatible with strong bases, reducing agents, and oxidizing agents.

Regulatory Status

GRAS listed. Lauric acid is listed as a food additive in the EAFUS list compiled by the FDA. Reported in the EPA TSCA Inventory.

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