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Fursultiamine

Fursultiamine 구조식 이미지
카스 번호:
804-30-8
상품명:
Fursultiamine
동의어(영문):
ttfd;judolor;linamin;Retar B1;adventan;diteftin;Alinaxin;alinaminf;Aliaron F;fursultiamin
CBNumber:
CB1161096
분자식:
C17H26N4O3S2
포뮬러 무게:
398.54
MOL 파일:
804-30-8.mol

Fursultiamine 속성

녹는점
130-136°C (decompos.)
끓는 점
652.3±55.0 °C(Predicted)
밀도
1.29
굴절률
1.6270 (estimate)
저장 조건
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
산도 계수 (pKa)
14.42±0.10(Predicted)
CAS 데이터베이스
804-30-8(CAS DataBase Reference)

안전

독성 LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi)

Fursultiamine C화학적 특성, 용도, 생산

Originator

Alinamin F,Takeda,Japan,1961

용도

Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.

Manufacturing Process

To a solution of 20 parts of thiamine hydrochloride in 30 parts of water is added an aqueous solution of sodium hydroxide (7.2 parts of NaOH in 30 parts of water), and the mixture is cooled with water. The mixture is allowed to stand for 30 minutes, 60 parts of chloroform is added, followed by a solution of 30 parts of crude sodium tetrahydrofurfurylthiosulfate in 30 parts of water, and the whole is stirred for 30 minutes. The chloroform layer is separated and the aqueous layer is extracted twice with 20 parts of chloroform. All the chloroform solutions are combined and shaken with 50 parts of 5% hydrochloric acid. The acid solution is decolorized and neutralized with alkali carbonate, whereupon thiamine tetrahydrofurfuryl disulfide separates out in the resinous state but soon solidifies [MP 129°C (decamp.)] . The yield is 16 parts. Recrystallization from ethyl acetate gives colorless prisms melting at 132°C (decomp.).

Therapeutic Function

Enzyme cofactor vitamin

Fursultiamine 준비 용품 및 원자재

원자재

준비 용품


Fursultiamine 공급 업체

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