Cemandil sodium salt
|
|
Cemandil sodium salt 속성
- 녹는점
- 190-193°C
- 저장 조건
- Inert atmosphere,Store in freezer, under -20°C
- 용해도
- 물에 잘 녹고, 메탄올에는 거의 녹지 않습니다.
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 2.6-3.0(at 25℃)
- 색상
- 흰색에서 황백색까지
- 수용성
- 물에 자유롭게 용해됩니다. 메탄올에 난용성
- CAS 데이터베이스
- 42540-40-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-42/43 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 3 | ||
RTECS 번호 | XI0380000 | ||
HS 번호 | 2941906000 | ||
기존화학 물질 | KE-05-0657 |
Cemandil sodium salt C화학적 특성, 용도, 생산
화학적 성질
White Solid용도
Cephalosporin antibacterial.정의
ChEBI: A cephalosporin prodrug having (R)-O-formylmandelamido and N-methylthiotetrazole side-groups.Mechanism of action
Cefamandole nafate has a formylated D-mandelic amide moiety at C-7. The formate ester is cleaved rapidly in the host to release the more active cefamandole. The esterification also apparently overcomes the instability of cefamandole when it is stored in dry form. This agent has increased activity against Haemophil us influenzae and some Gram-negative bacilli as compared with the first-generation cephalosporins. Loss of the 5-thio-l-methyl-l-H-tetrazole moiety (referred to sometimes by the acronym MT T) from C-3 is associated with prothrombin deficiency and bleeding problems as well as with an Antabuse-like acute alcohol intolerance. On the other hand, this grouping enhances potency and prevents metabolism by deacetylation. Like the other second-generation cephalosporins, cefamandole is more active against Gram-negative bacteria. The principle clinical use is for lower respiratory tract, skin and skin structures, and bone and joint infections as well as septicemia and urinary tract infections when the organisms are sensitive.Clinical Use
The D-mandeloyl moiety of Cemandil sodium salt appears toconfer resistance to a few β-lactamases, since some β-lactamase–producing, Gram-negative bacteria (particularlyEnterobacteriaceae) that show resistance to cefazolin andother first-generation cephalosporins are sensitive tocefamandole. Additionally, it is active against some ampicillin-resistant strains of Neisseria and Haemophilus spp.Although resistance to β-lactamases may be a factor in determiningthe sensitivity of individual bacterial strains tocefamandole, an early study indicated that other factors,such as permeability and intrinsic activity, are frequentlymore important. The L-mandeloyl isomer is significantlyless active than the D-isomer.Cemandil sodium salt 준비 용품 및 원자재
원자재
소듐 2-에틸헥사노에이트
염화 티오닐
개미산
Mandelic acid
[6R-[6alpha,7beta(R*)]]-7-[(formyloxy)phenylacetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(R)-(포르밀옥시)페닐아세트산
O-포르밀만델로일염화물
7-TMCA
(R)-(-)-Methyl mandelate
준비 용품
Cemandil sodium salt 공급 업체
글로벌( 263)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 +86-17332992504 |
sales8@hbganmiao.com | China | 300 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21666 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 |
yklbiotech@163.com | CHINA | 296 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Wuhan Chemwish Technology Co., Ltd | 027-67849912 |
sales@chemwish.com | CHINA | 10828 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
Cemandil sodium salt 관련 검색:
중탄산나트륨(중조) 수산화나트륨 N,N-디메틸아세트아미드 인산 트리나트륨 아세트산 나트륨 헥사메틸포스포릭트리아미드 디클로페낙 나트륨 벤조 산, 나트륨 염 구연산 나트륨, 무수 메틸 술폰 염화나트륨 포름산나트륨
5-Methyl-1H-benzotriazole
Cefamandole
1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE
8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
Cefamandole nafate impurity H
Cefamandole nafate double bond displacement impurity