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L-(+)-아르기닌

L-(+)-아르기닌
L-(+)-아르기닌 구조식 이미지
카스 번호:
74-79-3
한글명:
L-(+)-아르기닌
동의어(한글):
L-(+)-아르기닌;L-아르기닌;L-알기닌;아르기닌;L-아르기닌아미노발레르산;2-아미노-5-구아니디노발레르산;아르기닌ℓ;알지닌
상품명:
L(+)-Arginine
동의어(영문):
ARG;ABLL;ABL2;L-ARG;FLJ41441;FLJ31718;FLJ22224;H-ARG-OH;L-Argnie;AGRININE
CBNumber:
CB9226645
분자식:
C6H14N4O2
포뮬러 무게:
174.2
MOL 파일:
74-79-3.mol

L-(+)-아르기닌 속성

녹는점
222 °C (dec.)(lit.)
알파
27.1 º (c=8, 6N HCl)
끓는 점
305.18°C (rough estimate)
밀도
1.2297 (rough estimate)
굴절률
27 ° (C=8, 6mol/L HCl)
FEMA
3819 | L-ARGININE
저장 조건
Store at 0-5
용해도
H2O: 100 mg/mL
물리적 상태
powder
산도 계수 (pKa)
1.82, 8.99, 12.5(at 25℃)
색상
white
수소이온지수(pH)
10.5-12.0 (25℃, 0.5M in H2O)
optical activity
[α]20/D +27°, c = 8 in 6 M HCl
수용성
148.7 g/L (20 ºC)
감도
Air Sensitive
최대 파장(λmax)
λ: 260 nm Amax: ≤0.2
λ: 280 nm Amax: ≤0.1
Merck
14,780
JECFA Number
1438
BRN
1725413
안정성
Stable. Incompatible with strong oxidizing agents.
CAS 데이터베이스
74-79-3(CAS DataBase Reference)
NIST
L-Arginine(74-79-3)
EPA
L-Arginine(74-79-3)

안전

위험품 표기 Xn,T
위험 카페고리 넘버 36-36/37/38-20/21/22-61
안전지침서 24/25-36-26-45-53-39
WGK 독일 3
RTECS 번호 CF1934200
F 고인화성물질 10-23
TSCA Yes
위험 등급 IRRITANT
HS 번호 29252000
유해 물질 데이터 74-79-3(Hazardous Substances Data)

L-(+)-아르기닌 MSDS


L(+)-Arginine

L-(+)-아르기닌 C화학적 특성, 용도, 생산

용도

L-arginine은 콜라겐 생합성에 중요한 요소인 L-proline 형성에 전구체로 작용함으로 상처치유 기능을 가진다. L-arginine의 정맥주입은 외상환자에게 유용하고, 상처가 빨리 회복될 수 있게 돕는다. L-arginine은 당뇨병에 걸린 동물의 신장 기능을 증진시키고 만성적인 신장질환을 예방할 수 있다. 최근 방광염, 신장결석을 가진 환자를 대상으로 한 연구에서 L-arginine은 방광수축 억제와 신장결석 감소의 효과가 있었다.

화학적 성질

White crystalline powder

화학적 성질

Arginine is a diaminomonocarboxylic acid. The nonessential amino acid, arginine, is a urea cycle amino acid and a precursor for the neurotransmitter nitric oxide, which plays a role in the regulation of the brain’s system of dilation and constriction of small blood vessels. It is strongly alkaline and its water solutions absorb carbon dioxide from the air (FCC, 1996). Functionality in foods includes, but is not limited to, nutrient and dietary supplement

출처

Reported present in cheese, chocolate, eggs, meat, nuts and other products.

용도

Amino acid; nutrient.

정의

ChEBI: An L-alpha-amino acid that is the L-isomer of arginine.

Aroma threshold values

Detection at 100%, faint.

Taste threshold values

Taste characteristics at 1000 ppm: hint of sourness.

Chemical Synthesis

Enzymatically, arginine is formed in two reactions from citrulline. The first reaction (citrulline + succinate) is catalyzed by the enzyme arginosuccinate synthetase. It is ATP dependent and with the formation of a new C–N bond in the gaunidino group of arginosuccinate, water is removed and ATP is hydrolyzed. The second reaction is catalyzed by arginine synthetase and involves the scission of arginosuccinate with the formation of arginine and fumaric acid.

효소 저해제

This basic proteogenic amino acid and nitric oxide precursor (FWmonohydrochloride = 210.66 g/mol; FWfree-base = 174.20 g/mol; pKa values of 1.82, 8.99, and 12.48 (guanido) at 25°C), also called (S) -2-amino-5- guanidinopentanoate, is symbolized by Arg or R. There are six codons for arginine: AGA, AGG, CGU, CGC, CGA, and CGG. (The first two are not in the mitochondria of mammals, and AGA is also not in the mitochondria of Drosophila melanogaster). The guanidino group reacts with a number of reagents (e.g., phenylglyoxal and 1,2-cyclohexanedione), often resulting in loss of catalytic activity for enzymes with active-site arginine residues.. Arginine is also converted into creatine and creatinine. Target (s) : amino- acid N-acetyltransferase (N-acetylglutamate synthase; arginine is an activator of the mammalian and frog enzymes); N- acetylglutamate kinase; omptin; procollagen C- endopeptidase; peptidyl-Lys metalloendopeptidase, or Armillaria mellea protease, weakly inhibited; GfMEP, thermostable lysine- specific metalloendopeptidase; ancrod; ribosomal peptidyltransferase; putrescine carbamoyltransferase; lysine carboxypeptidase, or lysine (arginine) carboxypeptidase, or carboxypeptidase N; ornithine carbamoyltransferase; carboxypeptidase B; clostripain; carbamate kinase; homoserine kinase, weakly inhibited; saccharopine dehydrogenase ; argininosuccinate synthetase; Xaa-Arg Dipeptidase, or aminoacyl-lysine Dipeptidase; aminopeptidase B; g- glutamyl transpeptidase, weakly inhibited; group I self-splicing intron; kynureninase; asparagine synthetase, weakly inhibited ; alkaline phosphatase; acetylcholinesterase; glutamate decarboxylase, weakly inhibited; urate oxidase, weakly inhibited; carbamoyl-phosphate synthetase; glutamine synthetase; lysyl- tRNA synthetase; 2-aminohexano-6-lactam racemase; threonine ammonia-lyase, or threonine dehydratase; hyaluronate lyase; dihydrodipicolinate synthase ; lysine transport; 5-guanidino-2- oxopentanoate decarboxylase, or a-ketoarginine decarboxylase; weakly inhibited; ornithine decarboxylase ; kynureninase; agmatine deaminase; agmatinase; oligopeptidase B; venombin A (60; acrosin ; carboxypeptidase E; membrane alanyl aminopeptidase, or aminopeptidase N; [citrate lyase] deacetylase; guanidinoacetate kinase, weakly inhibited; homoserine kinase; ornithine aminotransferase; spermidine synthase; homocitrate synthase; leucyltransferase.

Purification Methods

S-Arginine crystallises from H2O as the dihydrate and as plates from EtOH. It also crystallises from 66% EtOH. Its solubility in H2O is 15% at 21o. Its isoelectric point is at pH 10.76. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1841 1961, Beilstein 4 IV 817.]

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