술파메톡사졸
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술파메톡사졸 속성
- 녹는점
- 166 °C
- 끓는 점
- 482℃
- 밀도
- 1.3915 (rough estimate)
- 굴절률
- 1.6630 (estimate)
- 인화점
- >110°(230°F)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- 물에는 거의 녹지 않으며, 아세톤에는 잘 녹고, 에탄올에는 거의 녹지 않습니다(96%). 묽은 수산화나트륨 용액과 묽은 산에 용해됩니다.
- 산도 계수 (pKa)
- pKa 5.60±0.05 (Uncertain)
- 물리적 상태
- Solid
- 색상
- 흰색에서 연한 노란색
- 수용성
- 에탄올이나 아세톤에 용해됩니다. 물에 아주 약간 용해됨
- 감도
- Light Sensitive
- Merck
- 14,8918
- BRN
- 6732984
- BCS Class
- 2,4
- 안정성
- 안정적이지만 빛에 민감합니다. 강한 산화제와 호환되지 않습니다.
- InChIKey
- JLKIGFTWXXRPMT-UHFFFAOYSA-N
- CAS 데이터베이스
- 723-46-6(CAS DataBase Reference)
- IARC
- 3 (Vol. Sup 7, 79) 2001
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-43-22 | ||
안전지침서 | 26-36-36/37/39-22 | ||
WGK 독일 | 2 | ||
RTECS 번호 | WP0700000 | ||
TSCA | Yes | ||
위험 등급 | IRRITANT | ||
HS 번호 | 29350090 | ||
유해 물질 데이터 | 723-46-6(Hazardous Substances Data) | ||
독성 | LD50 orally in mice: 3662 mg/kg (Yamamoto) | ||
기존화학 물질 | KE-01462 |
술파메톡사졸 C화학적 특성, 용도, 생산
개요
Like sulfisoxazole, this drug is effective in treating infections caused by streptococci, gonococci, pneumococci, staphylococci as well as colon bacillus. Unlike sulfisoxazole, only about 70% of it binds with proteins in the plasma after oral administration, and it diffuses mostly to tissues and tissue fluids. However, since it is removed much slower than sulfisoxazole, it does not require frequent administration and is also the drug of choice for many systemic infections. Moreover, it is an ingredient of a combined drug named bactrim, biseptol, and so on (which will be examined later on), which has a fixed correlation with trimethoprim. Synonyms of this drug are gantanol, sinomin, sulfisomezole, and others.화학적 성질
solid정의
ChEBI: An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.Antimicrobial activity
The intrinsic activity is similar to that of sulfadiazine.일반 설명
Sulfamethoxazole’s plasma half-life is 11 hours. Sulfamethoxazole is a sulfonamide drug closely relatedto sulfisoxazole in chemical structure and antimicrobial activity.It occurs as a tasteless, odorless, almost white crystallinepowder. The solubility of sulfamethoxazole in the pHrange of 5.5 to 7.4 is slightly lower than that of sulfisoxazole but higher than that of sulfadiazine, sulfamerazine, or sulfamethazine.Following oral administration, sulfamethoxazole is notabsorbed as completely or as rapidly as sulfisoxazole, andits peak blood level is only about 50% as high.공기와 물의 반응
Insoluble in water.화재위험
Flash point data for Sulfamethoxazole are not available but Sulfamethoxazole is probably non-flammable.Pharmaceutical Applications
This is the sulfonamide component of co-trimoxazole. It is slightly soluble in water.Pharmacokinetics
Oral absorption: 85%Cmax 800 mg oral: c.50 mg/L after 3–6 h
Plasma half-life: 6–20 h
Volume of distribution: 12–18 L
Plasma protein binding: 65%
Penetration of extravascular sites, including the CSF, is good. It crosses the placenta and achieves levels in breast milk of about 10% of the simultaneous plasma concentration. It is extensively metabolized, but about 30% of the dose is excreted unchanged in urine so that high concentrations are achieved.
Clinical Use
Sulfamethoxazole is used only in combination with the diaminopyrimidine trimethoprim.부작용
Unwanted effects are those common to sulfonamides. In addition, benign intracranial hypertension has been reported in children. Most side effects of co-trimoxazole are thought to be attributable to the sulfonamide component.Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx.술파메톡사졸 준비 용품 및 원자재
원자재
다이메틸옥살레이트
아세톤
옥살산디에틸
4-(아세틸아미노)벤젠설포닐 클로라이드
클로로포름
4-아세트아미도벤젠술폰아미드
클로로술폰산
메틸산 나트륨
소다의 염산
염산 히드록실아민
메틸이소옥사졸
준비 용품
술파메톡사졸 공급 업체
글로벌( 651)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5987 | 58 |
Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 |
sales@suikangpharm.com | China | 311 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 |
sales@sdperfect.com | China | 294 | 58 |
Sigma Audley | +86-15937194204 +86-18126314766 |
nova@sh-teruiop.com | China | 491 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21666 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |