눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P312
불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P321
(…) 처치를 하시오.
P322
특정 조치(라벨의 … 참조)
P332+P313
피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P333+P313
피부자극성 또는 홍반이 나타나면 의학적인 조치·조언를 구하시오.
P362
오염된 의복을 벗고 세척 후에 재사용하기
P363
다시 사용전 오염된 의류는 세척하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2
0
에소메프라졸 C화학적 특성, 용도, 생산
개요
Esomeprazole, formulated as a magnesium salt, reached the market as a treatment for
acid-related diseases such as gastro-esophageal reflux (GERD) disease including peptic
ulcer disease and reflux esophagitis. Esomeprazole (formerly perprazole) is the active (S)-
enantiomer of omeprazole (1988) and the first proton pump inhibitor developed as an
optical isomer. It can be obtained by several routes such as asymmetric oxidation of the
pro-chiral pyridylmethyl benzimidazole sulfide, separation from the racemic sulfoxide by
chiral chromatography or separation of a diastereomeric mixture obtained from the racemic
compound and a chiral acid, followed by hydrolysis. Biochemical studies have shown that
esomeprazole irreversibly inhibits the gastric H+/K+-adenosine triphosphatase (ATPase),
an enzyme system involved at the secretory surface of the stomach’s parietal cells
responsible for the secretion of gastric acid. Compared with racemic omeprazole in healthy
subjects, esomeprazole has higher bioavailability, is absorbed more rapidly and exhibits a
more uniform and predictable dose-response with higher plasma levels, leading to less
inter-individual variability between slow and rapid metabolizers. In extensive clinical trials
in patients suffering from GERD symptoms, esomeprazole provided superior acid control
and significantly reduced the healing time compared to omeprazole.
용도
(-)-Omeprazole can be used to treat migraine.
용도
Esomeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough.
정의
ChEBI: A 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole that has S configuration at the sulfur atom. An inhibitor of gastric acid secretion, it is used (generally as its sodium or magnesium
alt) for the treatment of gastro-oesophageal reflux disease, dyspepsia, peptic ulcer disease, and Zollinger-Ellison syndrome.
