디옥틸 설포숙시네이트 나트륨염
|
|
디옥틸 설포숙시네이트 나트륨염 속성
- 녹는점
- 173-179 °C(lit.)
- 끓는 점
- 82.7°C
- 밀도
- 1.1
- 증기압
- 0Pa at 25℃
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 메탄올: 20°C에서 0.1°M, 투명, 무색
- 물리적 상태
- 밀랍 같은 고체
- Specific Gravity
- 1.005_PERCENT VOLATILE: 40
- 색상
- 하얀색
- 수용성
- 1.5 g/100 mL (25 ºC)
- 감도
- Hygroscopic
- 최대 파장(λmax)
- λ: 260 nm Amax: 0.1
λ: 280 nm Amax: 0.05
- Merck
- 14,3401
- BRN
- 4117588
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
- InChIKey
- APSBXTVYXVQYAB-UHFFFAOYSA-M
- LogP
- 1.998 at 20℃
- CAS 데이터베이스
- 577-11-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 22-38-41-36/37/38 | ||
안전지침서 | 26-39-37/39-36 | ||
WGK 독일 | 2 | ||
RTECS 번호 | WN0525000 | ||
F 고인화성물질 | 3-10 | ||
TSCA | Yes | ||
HS 번호 | 29171900 | ||
유해 물질 데이터 | 577-11-7(Hazardous Substances Data) | ||
독성 | LD50 oral in rat: 1900mg/kg | ||
기존화학 물질 | KE-32402 |
디옥틸 설포숙시네이트 나트륨염 C화학적 특성, 용도, 생산
화학적 성질
white solid, often supplied as an aqueous solution용도
Dioctyl sulfosuccinate sodium salt is a wetting and emulsifying agent that is slowly soluble in water, having a solubility of 1 g in 70 ml of water. It functions as a wetting agent in fumaric acid-containing powdered fruit drinks to help the acid dissolve in water. It is used as a stabilizing agent on gums at not more than 0.5% by weight of the gum. It is used as a flavor potentiator in canned milk where it improves and maintains the flavor of the sterilized milk during storage. It also functions as a processing aid in the manufacture of unrefined sugar. It is also termed sodium dioctylsulfosuccinate.생산 방법
Maleic anhydride is treated with 2-ethylhexanol to produce dioctyl maleate, which is then reacted with sodium bisulfite.일반 설명
Odorless colorless to white waxy solid. Sinks and mixes slowly with water.공기와 물의 반응
Mixes slowly with water.반응 프로필
Docusate sodium causes foaming and spreading of water. Assists in putting out fires by water. [USCG, 1999].건강위험
Liquid is strong irritant to eye and may irritate skin by removing natural oils. Ingestion causes diarrhea and intestinal bloating.화재위험
Behavior in Fire: Causes foaming and spreading of water. Assists in putting out fires by water.Pharmaceutical Applications
Docusate sodium and docusate salts are widely used as anionic surfactants in pharmaceutical formulations. Docusate sodium is mainly used in capsule and direct-compression tablet formulations to assist in wetting and dissolution.Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. A skin and severe eye irritant. See also ESTERS. When heated to decomposition it emits toxic fumes of SOx and Na2O.Safety
Docusate salts are used in oral formulations as therapeutic agents for their fecal softening and laxative properties. As a laxative in adults, up to 500mg of docusate sodium is administered daily in divided doses; in children over 6 months old, up to 75 mg in divided doses is used. The quantity of docusate sodium used as an excipient in oral formulations should therefore be controlled to avoid unintended laxative effects. Adverse effects associated with docusate sodium include diarrhea, nausea, vomiting, abdominal cramps, and skin rashes. As with the chronic use of laxatives, the excessive use of docusate sodium may produce hypomagnesemia.Docusate salts are absorbed from the gastrointestinal tract and excreted in bile; they may cause alteration of the gastrointestinal epithelium. The gastrointestinal or hepatic absorption of other drugs may also be affected by docusate salts, enhancing activity and possibly toxicity. Docusate sodium should not be administered with mineral oil as it may increase the absorption of the oil.
LD50 (mouse, IV): 0.06 g/kg
LD50 (mouse, oral): 2.64 g/kg
LD50 (rat, IP): 0.59 g/kg
LD50 (rat, oral): 1.9 g/kg
저장
Docusate sodium is stable in the solid state when stored at room temperature. Dilute aqueous solutions of docusate sodium between pH 1–10 are stable at room temperature. However, at very low pH (<1) and very high pH (>10) docusate sodium solutions are subject to hydrolysis.The solid material is hygroscopic and should be stored in an airtight container in a cool, dry place.
Purification Methods
Dissolve it in MeOH and the inorganic salts which precipitate are filtered off. Water is added and the solution is extracted several times with hexane. The residue is evaporated to one-fifth its original volume, *benzene is added and azeotropic distillation is continued until no water remains. The solvent is evaporated. The white residual solid is crushed and dried in vacuo over P2O5 for 48hours [El Seoud & Fendler J Chem Soc, Faraday Trans 1 71 452 1975]. [Beilstein 4 IV 114.] It solubilises major myelin trans membrane proteolipids, and forms reverse micelles in hydrocarbon solvents.비 호환성
Electrolytes, e.g. 3% sodium chloride, added to aqueous solutions of docusate sodium can cause turbidity. However, docusate sodium possesses greater tolerance to calcium, magnesium, and other polyvalent ions than do some other surfactants. Docusate sodium is incompatible with acids at pH < 1 and with alkalis at pH > 10.Regulatory Status
GRAS listed. Included in the FDA Inactive Ingredients Database (IM injections; oral capsules, suspensions, and tablets; also topical formulations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.디옥틸 설포숙시네이트 나트륨염 준비 용품 및 원자재
원자재
준비 용품
디옥틸 설포숙시네이트 나트륨염 공급 업체
글로벌( 715)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50002 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 998 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
Shandong Juchuang Chemical Co., LTD | +86-18885615001 +86-18885615001 |
admin@juchuangchem.com | China | 387 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21703 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9359 | 55 |
Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 |
kaia@neputrading.com | China | 1011 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29919 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |