ChemicalBook > Product Catalog >API >Circulatory system drugs >Antiarrhythmics Drugs >Pindolol

Pindolol

Pindolol Suppliers list
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Pindolol
CAS:13523-86-9
Company Name: Chemwill Asia Co.,Ltd.
Tel: 86-21-51086038
Email: chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com
Products Intro: CAS:13523-86-9
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:Pindolol;1-(1H-Indol-4-yloxy)-3-[(1-Methylethyl)aMino]-2-propanol
CAS:13523-86-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Chemsky(shanghai)International Co.,Ltd.  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:Pindolol
CAS:13523-86-9
Purity:98%
Company Name: Syntechem Co.,Ltd  
Tel: QQ 956912955,421151915
Email: qyh@syntechem.com
Products Intro: Product Name:1-((1H-indol-4-yl)oxy)-3-(isopropylaMino)propan-2-ol
CAS:13523-86-9
Purity:95% Package:On request
Pindolol Basic information
Product Name:Pindolol
Synonyms:1-(1H-INDOL-4-YLOXY)-3-[(1-METHYLETHYL)AMINO]-2-PROPANOL;1-[1H-INDOL-4-YLOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL;1-(INDOL-4-YLOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL;(+-)-4-(2-hydroxy-3-(isopropylamino)propoxy)indole;(+-)-lb46;(rs)-pindolol;carvisken;Decreten
CAS:13523-86-9
MF:C14H20N2O2
MW:248.32
EINECS:236-867-9
Product Categories:Heterocyclic Compounds;Pindolol;Serotonin receptor;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;VISKEN
Mol File:13523-86-9.mol
Pindolol Structure
Pindolol Chemical Properties
Melting point 167-171 °C(lit.)
Boiling point 391.39°C (rough estimate)
density 1.0606 (rough estimate)
refractive index 1.5110 (estimate)
storage temp. 2-8°C
solubility 0.1 M NaOH: 0.2 mg/mL
form powder
pkapKa 9.26 (Uncertain)
color white to off-white
Merck 13,7525
CAS DataBase Reference13523-86-9(CAS DataBase Reference)
NIST Chemistry ReferencePindolol(13523-86-9)
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
RIDADR 3249
WGK Germany 3
RTECS UB6660000
HazardClass 6.1(b)
PackingGroup III
Hazardous Substances Data13523-86-9(Hazardous Substances Data)
MSDS Information
Pindolol Usage And Synthesis
Chemical PropertiesWhite Solid
UsesMixed β-adrenergic blocker and serotonin 5HT1A-receptor antagonist. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.
DefinitionChEBI: A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.
Brand nameVisken (Novartis).
Biological Activity5-HT 1A/1B ? receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β 3 -adrenoceptors.
Enzyme inhibitorThis antihypertensive agent (FW = 248.33 g/mol; CAS 13523-86-9), also known as 1- (1H-indol-4-yloxy) -3-[ (1-methylethyl) amino]-2-propanol and Visken, is a moderately lipophilic b1-adrenergic receptor antagonist and a 5- HT1A serotonin receptor partial agonist, Ki = 30 nM (1-3). Note: The pharmacologically active stereomer is the (–) -S-enantiomer. See also Iodocyanopindolol Target (s) : glycogenolysis in rat liver; endogenous prostaglandin synthesis; hepatic 3,5,3'-triiodothyronine production; inhibition of thromboxane and prostacyclin production in whole blood; rat brain serotonin (5-HT) synthesis.
Metabolic pathwaySeveral metabolites of pindolol formed in vitro are detected after a 24 h incubation of human hepatocytes in both pure culture and co-culture by adding rat liver epithelial cells. The hepatocytes are able to oxidize the isopropyl amine moiety and the pyrrole ring of the indole moiety and conjugate pindolol as sulfates and glucuronides.
MetabolismPindolol (Visken) is extensively absorbed from the gastrointestinal tract. First-pass metabolism is estimated at about 15%, and its plasma half-life is on the order of 3 to 4 hours.The binding of pindolol to plasma proteins is approximately 50%.The metabolic fate of pindolol is not completely understood, although 50% of an administered dose is recovered, primarily in the urine, as unchanged drug.
Pindolol Preparation Products And Raw materials
Raw materialsResorcine-->Isopropylamine-->4-Hydroxyindole
Tag:Pindolol(13523-86-9) Related Product Information
4-[3-[(1,1-DIMETHYLETHYL)AMINO]-2-HYDROXYPROPOXY]-1H-INDOLE-2-CARBOXYLIC ACID, 1-METHYLETHYL ESTER Bopindolol (-)-CYANOPINDOLOL, [125I]IODO- rac Mepindolol-d7 EXP 063 BOPINDOLOL MALONATE (-)-PINDOLOL, [125I]IODO- 1-(Cyclohexylamino)-3-((2-(4-methoxyphenyl)-1-phenyl-1H-indol-4-yl)oxy )-2-propanol HCl 2-Propanol, 1-(cyclohexylamino)-3-((1,2,3-trimethyl-1H-indol-4-yl)oxy) -, monohydrochloride 2-Propanol, 1-((2-(4-methoxyphenyl)-1-isopropyl-1H-indol-4-yl)oxy)-3-i sopropylamino-, hexanedioate (1:1) (salt) CARAZOLOL HCL Pindolol Methoxydiethylborane Tris Base Indole-3-acetic acid 6-Aminocaproic acid Glycine Indole