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Brinzolamide

Brinzolamide Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
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Products Intro: Product Name:138890-62-7
CAS:138890-62-7
Purity:0.99 Package:25KG,5KG;1KG;500G
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CAS:138890-62-7
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:(R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide
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Products Intro: Product Name:Brinzolamide
CAS:138890-62-7
Purity:99% Package:1kg;2USD

Lastest Price from Brinzolamide manufacturers

  • Brinzolamide
  • US $0.00-0.00 / KG
  • 2020-01-07
  • CAS:138890-62-7
  • Min. Order: 5mg
  • Purity: 99%
  • Supply Ability: 2000tons
  • Brinzolamide
  • US $2.00 / kg
  • 2019-07-06
  • CAS:138890-62-7
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
Brinzolamide Basic information
Product Name:Brinzolamide
Synonyms:H-Thieno[3,2-e]-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (4R)-;Brinzolamide (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxide;(5R)-5-Ethylamino-3-(3-methoxypropyl)-2,2-dioxo-2?6,9-dithia-3-azabicyclo[4.3.0]nona-7,10-diene-8-sulfonamide;ANTI-GAGE7 (C-TERM) antibody produced in rabbit;Cancer/testis antigen 4.7;CT4.7;G antigen 7;GAGE-12I
CAS:138890-62-7
MF:C12H21N3O5S3
MW:383.51
EINECS:620-511-8
Product Categories:Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Brinzolamide;BETOPTIC
Mol File:138890-62-7.mol
Brinzolamide Structure
Brinzolamide Chemical Properties
Melting point 130.0 to 134.0 °C
Boiling point 586.0±60.0 °C(Predicted)
density 1.50±0.1 g/cm3(Predicted)
storage temp. ?20°C
solubility DMSO: ≥10mg/mL
form powder
pka9.62±0.40(Predicted)
color white to beige
Merck 14,1376
InChIKeyHCRKCZRJWPKOAR-JTQLQIEISA-N
CAS DataBase Reference138890-62-7(CAS DataBase Reference)
Safety Information
WGK Germany 3
RTECS XJ9095055
HS Code 2935904000
MSDS Information
Brinzolamide Usage And Synthesis
DescriptionBrinzolamide was introduced as Azopt in the US for the treatment of elevated intraocular pressure (IOP) in patients with ocular hypertension or openangle glaucoma. Brinzolamide is a potent inhibitor of human carbonic anhydrase Ⅱ lowering IOP after topical administration . It is the second of this class after dorzolamide (1995). Brinzolamide can be prepared in an eight-step sequence from 3-acetyl-2,5-dichlorothiophene. In patients with primary open-angle glaucoma or ocular hypertension, brinzolamide produced significant reductions in IOP and showed less ocular discomfort than dorzolamide.
Chemical PropertiesCrystalline Solid
OriginatorAlcon (US)
UsesCarbonic anhydrase inhibitor. Antiglaucoma agent
Usesantihypertensive, beta-blocker, antianginal
UsesFor the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
IndicationsBrinzolamide, a heterocyclic sulfonamide, is a topical CAI suspension that has a high affinity for the carbonic anhydrase II isoenzyme.Because the ocular hypotensive effect of the drug is equivalent whether dosed twice or three times daily, brinzolamide 1% may be administered twice daily.
Brand nameAzopt (Alcon).
Clinical UseBrinzolamide is indicated for the treatment of elevated IOP in patients with ocular hypertension or open-angle glaucoma.The drug is commercially available as a sterile 1.0% aqueous suspension with a pH of approximately 7.5. BAC 0.01% is added as a preservative.
The efficacy and safety of brinzolamide 1%, either two or three times daily, were evaluated in 572 patients with open-angle glaucoma or ocular hypertension against timolol 0.5% twice daily and dorzolamide 2.0% three times daily. Mean IOP changes were -3.8 to -5.7 mm Hg, -4.2 to -5.6 mm Hg, and-4.3 to-5.9 mm Hg for two- and three-times-daily brinzolamide and dorzolamide dosing, respectively. The mean IOP changes for timolol 0.5% ranged from -5.6 to -6.3 mm Hg (Figure 10-15). Brinzolamide was well tolerated, with 1.8% (twice daily) and 3% (three times daily) of patients reporting ocular discomfort versus 16.4% with dorzolamide. Complaints of blurred vision were higher with brinzolamide (5–6%) than dorzolamide (1%) or timolol (0%).
A meta-analysis of randomized clinical trials reported peak ocular hypotensive effect on IOP of 17% (19% to 15%) and trough effect of 17% (19% to 15%).
Side effectsBoth brinzolamide and dorzolamide exhibit similar taste abnormalities. A single case report of the development of metabolic acidosis from topical brinzolamide has been described after twice-daily dosing. Other adverse events are negligible for brinzolamide except for some blurring of vision, attributable to its suspension vehicle.
Veterinary Drugs and TreatmentsBrinzolamide is chemically similar to dorzolamide and reduces aqueous humor production by altering H+/Na+ active transport mechanisms associated with aqueous humor production in the ciliary epithelial cells. It can be used as a substitute for dorzolamide and some patients that exhibit excessive topical irritation following application of dorzolamide drops, tolerate brinzolamide better or vice versa. Cats seem to be particularly sensitive to irritation from topical dorzolamide and often brinzolamide can be used in these patients. Comparative data is available suggesting that brinzolamide and dorzolamide are equally effective in animal patients.
PrecautionsBrinzolamide has the same contraindications and precautions as dorzolamide.
Tag:Brinzolamide(138890-62-7) Related Product Information
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