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Tetracycline

Tetracycline Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Tetracycline
CAS:60-54-8
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:60-54-8
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Tetracycline
CAS:60-54-8
Company Name: Chengdu GLP Biotech Co., Ltd
Tel: 13350802083
Email: scglp@glp-china.com
Products Intro: Product Name:Tetracycline
CAS:60-54-8
Purity:98% Package:1g;5g;10g
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Tetracycline
CAS:60-54-8
Purity:98% Package:1KG;1USD

Lastest Price from Tetracycline manufacturers

  • Tetracycline
  • US $1.00 / KG
  • 2018-08-21
  • CAS:60-54-8
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
Tetracycline Basic information
Product Name:Tetracycline
Synonyms:abricycline;achromycin(naphthacenederivative);achromycin(naphthracenederivatives);agromicina;ambramicina;ambramycin;amycin;biocycline
CAS:60-54-8
MF:C22H24N2O8
MW:444.44
EINECS:200-481-9
Product Categories:Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics T-ZAntibiotics;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisSpectrum of Activity;L - ZAntibiotics;Mechanism of Action;Tetracyclines;Inhibitors;Peptide Synthesis/Antibiotics
Mol File:60-54-8.mol
Tetracycline Structure
Tetracycline Chemical Properties
Melting point 175-177 °C(lit.)
alpha D25 -257.9° (0.1N HCl); D25 -239° (methanol)
Boiling point 554.44°C (rough estimate)
density 1.3809 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. 2-8°C
solubility 95% ethanol: soluble12.5mg/mL
form powder
pkapKa (50% aq DMF): 8.3, 10.2(at 25℃)
color yellow to yellow orange
optical activity[α]25/D -239° in methanol (Specific rotation ) &_& [α]25/D -257.9°, c = 0.1 M HCl mol (Specific rotation )
Water Solubility Limited solubility in water. Soluble in 1M HCl with heating.
Merck 13,9271
BRN 2230417
CAS DataBase Reference60-54-8(CAS DataBase Reference)
NIST Chemistry ReferenceTetracycline(60-54-8)
EPA Substance Registry System2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5, 5a,6,11,12a-octahydro-3,6, 10,12,12a-pentahydroxy-6- methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-(60-54-8)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/37/38
Safety Statements 22-36-26
WGK Germany 3
RTECS QI8750000
3-8-10
HS Code 29413000
Hazardous Substances Data60-54-8(Hazardous Substances Data)
ToxicityLD50 in rats, mice (mg/kg): 807, 808 orally (Goldenthal)
MSDS Information
ProviderLanguage
SigmaAldrich English
Tetracycline Usage And Synthesis
Chemical PropertiesCrystalline Solid
Chemical PropertiesTetracycline trihydrate is a white crystalline substance.
Usesantibactierial
Usesantibacterial, antiamebic, antirickettsial
UsesTetracycline is a linear, tetracyclic, broad spectrum antibiotic first prepared chemically by dechlorination of chlortetracycline and subsequently isolated from several Streptomyces species. Tetracycline has broad spectrum antibacterial and antiprotozoan activity, and acts by binding to the 30S and 50S ribosomal subunits blocking protein synthesis. Tetracycline is a pigment and, like many pigments, is degraded by light, oxygen, trace metal ions and pH variations. The purity of tetracycline is often variable, with significant levels of degradation products.
UsesTetracycline is a broad spectrum polyketide antibiotic. It is used clinically to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, and Brill-Zinsser disease. It is used to treat upper respiratory infections and acne. It is used to study multidrug resistance as well as potential side effects such as acute pancreatitis.
UsesAntibiotic substance produced by Streptomyces spp. Antiamebic; antibacterial; antirickettsial
Antimicrobial activityIt is also active against V. cholerae, chlamydiae, rickettsiae and spirochetes.
Pharmaceutical ApplicationsA fermentation product of Streptomyces aureofaciens, also produced from chlortetracycline. Available as the hydrochloride for oral and topical use.
PharmacokineticsOral absorption: c.75%
Cmax 500 mg oral: 2–4 g/L
Plasma half-life: 8.5 h
Volume of distribution: c.1.3 L/kg
Plasma protein binding: c.50–60%
Absorption
When taken with food, absorption is reduced by approximately 50%. Steady-state plasma concentrations of 4–5 mg/L occur after oral doses of 500 mg every 6 h. Women appear to produce higher concentrations than men. Divalent and trivalent cations such as calcium and aluminum present in antacids and milk interfere with absorption through chelation, as does ferrous sulfate. H2-receptor antagonists, by raising gastric pH, also interfere with absorption through impaired drug dissolution. Despite the effect of gastric pH, oral absorption is not affected in elderly patients with achlorhydria.
Distribution
Tetracycline is widely distributed in the body tissues. In particular, it penetrates well into the prostate, uterus, ovary and bladder, and also appears to be preferentially taken up by the gastrointestinal tract. It is also detectable within reticuloendothelial cells of the liver, spleen and bone marrow.
Protein binding is reduced in states of malnutrition. It is also bound to bone, dentine and tooth enamel of unerupted teeth. Sputum concentrations of 0.4–2.6 mg/L have been detected after 250 mg oral dosage every 8 h. Maxillary sinus secretions and bronchial mucosal tissue have concentrations comparable to those of serum.
CSF penetration is poor, but increases with meningeal inflammation. It crosses the placenta readily to enter the fetal circulation, where it achieves 25–75% of the maternal plasma concentration. It is also present in breast milk.
Metabolism
A small amount is metabolized to 4-epitetracycline.
Excretion
Tetracycline is largely eliminated unchanged by glomerular filtration, with more than 50% excreted within 24 h after oral administration. This rises to approximately 70% following parenteral administration. Urinary concentrations of 300 mg/L occur within the first 2 h and persist for up to 12 h. Urinary excretion is enhanced in alkaline urine. Renal clearance is reduced in severe protein calorie malnutrition, possibly through reduced glomerular filtration. It accumulates in the presence of renal failure and is only slowly removed by hemodialysis and minimally by peritoneal dialysis. The bile is an important route of excretion, accounting for about one-third of the dose. Biliary concentrations may be 10–25 times those found in serum. Impaired hepatic function or biliary obstruction leads to an increase in blood levels.
Clinical UseAlong with doxycycline it is one of the most commonly used tetracyclines.
Side effectsThe gastrointestinal side effects common to the group are the most frequent cause of intolerance. Metallic taste and glossitis are less burdensome than diarrhea. Antibiotic-associated enterocolitis caused by Clostridium difficile toxin and staphylococcal enterocolitis have been reported. Steatorrhea and acute pancreatitis has also been described. Irritation and ulceration of the esophagus has occurred with local impaction of the drug. C. albicans overgrowth is common and may result in symptomatic oral or vaginal candidiasis and occasionally candida diarrhea.
Hypersensitivity reactions include contact dermatitis, urticaria, facial edema and asthma. Anaphylaxis is rare. A lupus syndrome has been reported, but its cause is uncertain. Photosensitivity can be severe and cause vesiculation, desquamation and onycholysis. The Jarisch–Herxheimer reaction has been observed in the treatment of syphilis, louse-borne relapsing fever, leptospirosis, brucellosis and tularemia. Deposition in deciduous teeth and bone (where it may temporarily inhibit growth) is of continuing concern. Between 3% and 44% of administered tetracycline is incorporated in the inorganic phase of bone, which may become visibly discolored and fluoresce. Concentrations as high as 290 mg/g have been recorded in bone in those on long-term tetracycline treatment for acne.
Existing renal insufficiency may be aggravated and is probably related to the antianabolic effect of this class of drugs; interference with protein synthesis places an additional burden on the kidney from amino acid metabolism. Acute renal failure may occur and can be aggravated by drug-induced diarrhea. Dehydration and salt loss from diuretic therapy may aggravate nephrotoxicity. Methoxyflurane and tetracycline in combination may be synergistically nephrotoxic.
An uncommon but serious adverse reaction is acute fatty liver, which may be complicated by renal insufficiency and electrolyte abnormalities. This is most likely to occur with highdose intravenous administration, especially during pregnancy. Hematological toxicity is uncommon. Leukopenia, thrombocytopenia and hemolytic anemia have been reported.
Altered coagulation may also occur with high intravenous dosage. Phagocyte function may be impaired as a result of the increased excretion of vitamin C.
Neurological toxicity is uncommon but includes benign intracranial hypertension . A transient myopathy has complicated long-term oral use for the treatment of acne, while intravenous administration has caused increased muscle weakness in those with myasthenia gravis and has also potentiated curare-induced neuromuscular blockade.
Metabolic effects include: precipitation of lactic acidosis in diabetic patients receiving phenformin; a reduction in vitamins B12, B6 and pantothenic acid with long-term therapy; interference with laboratory tests of urinary catecholamines and urinary tests for glucose (Clinitest and Benedict’s); and elevation of serum lithium concentrations. In addition, warfarin is potentiated and failure of oral Contraception occurs.
Potential ExposureTetracycline is an antibiotic medicine used as capsules, tablets, or intravenous injections against certain infections in humans and animals.
First aidIf this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
ShippingUN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification MethodsTetracycline crystallises from toluene or aqueous MeOH as the trihydrate. [Stephen et al. J Am Chem Soc 76 3568 1954, Beilstein 14 IV 2625.]
IncompatibilitiesAlthough no dangerous incompatibilities are reported, the potency of this medicine is reduced by heat, sunlight, and solutions with pH <2; and destroyed by caustic hydroxide solutions.
Waste DisposalIt is inappropriate and possibly dangerous to the environment to dispose of expired or waste pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.
Tetracycline Preparation Products And Raw materials
Tag:Tetracycline(60-54-8) Related Product Information
Tetracycline Phosphate,TETRACYCLINE PHOSPHATE COMPLEX (-)-N-[[4-(2-Hydroxyethyl)piperazino](carboxy)methyl]tetracycline oleomorphocycline TETRACYCLINE, [7-3H(N)] Pecocycline sigmamycin n-(1-pyrrolidinylmethyl)-tetracyclin Prolinomethyltetracycline Tris Base AMINO ACIDS Tetracycline Minocycline TETRACYCLINE HCL,TETRACYCLINE HYDROCHLORIDE,TETRACYCLINE HYDROCHLORIDE CRYSTALLINE,TETRACYCLINE HYDROCHLORIDE GAMMA-*IRRADI ATED MOLECU,TETRACYCLINE HYDROCHLORIDE, BIOTECHNOLOG,TETRACYCLINE HYDROCHLORIDE USP,TETRACYCLINE HYDROCHLORIDE CELL CULTURE TESTED,Tetracycline hydrochloride, 'can be used as secondary standard',TETRACYCLINE HYDROCHLOIRDE,Tetracycline bydrochloride ALTRENOGEST Chlorotetracycline 6-Aminocaproic acid Glycine 3-Aminophenol