ChemicalBook CAS DataBase List 2-Fluoroanisole

2-Fluoroanisole synthesis

7synthesis methods

Product Name:2-Fluoroanisole
CAS Number:321-28-8
Molecular formula:C7H7FO
Molecular Weight:126.13

367-12-4 Synthesis

367-12-4
421 suppliers
$5.00/10g

74-88-4
340 suppliers
$15.00/10g

321-28-8
375 suppliers
$6.00/1g

Yield:321-28-8 98%

Reaction Conditions:

Stage #1:2-fluorophenol with sodium hydride in N,N-dimethyl-formamide at 0 - 20; for 1.5 h;
Stage #2:methyl iodide in N,N-dimethyl-formamide for 16 h;

Steps:

D.D1
D 1. 1 -Fluoro-2-methoxy-benzeneTo a slurry of NaH (28.8g, O.όOmol) in dry DMF (500ml) at 0 ⁰C was added 2-fluoro phenol (5Og, 0.446mol) slowly over a period of 30min and stirred for Ih at room EPO temperature. To this was added methyl iodide (19Og, 1.33mol) and the reaction mixture was stirred for 16h under nitrogen and poured into ice-water (1.5L). The product was extracted with ethyl acetate (2 x 200ml), washed with water, brine and dried. The solvent was removed under vacuum to afford 55g (98%) of the title compound.

References:

ASTEX THERAPEUTICS LIMITED;THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL;ASTRAZENECA AB WO2006/136829, 2006, A2 Location in patent:Page/Page column 122-123

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367-12-4 Synthesis

367-12-4
421 suppliers
$5.00/10g

77-78-1
288 suppliers
$19.69/1ml

321-28-8
375 suppliers
$6.00/1g

References

90-05-1 Synthesis

90-05-1
731 suppliers
$5.00/1g

321-28-8
375 suppliers
$6.00/1g

References

100-66-3 Synthesis

100-66-3
508 suppliers
$10.00/5G

459-60-9 Synthesis

459-60-9
346 suppliers
$7.00/5g

321-28-8
375 suppliers
$6.00/1g

References

578-57-4
307 suppliers
$6.00/10g

321-28-8
375 suppliers
$6.00/1g

100-66-3 Synthesis

100-66-3
508 suppliers
$10.00/5G

References

2-Fluoroanisole Related Search:

Florfenicol Transfluthrin Anisole 4-Fluorobenzaldehyde 2-Fluorobenzaldehyde 2-Fluorobenzoyl chloride 2-Fluorobenzoic acid 2-Fluorophenylacetic acid alpha-Chloro-o-fluorotoluene 4-Fluoroanisole