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Cefotaxim-natrium Produkt Beschreibung

Cefotaxime sodium Struktur
64485-93-4
CAS-Nr.
64485-93-4
Bezeichnung:
Cefotaxim-natrium
Englisch Name:
Cefotaxime sodium
Synonyma:
ctx;hr756;Pretor;FIR-756;ru24756;Cefotax;Chemcef;Tolycar;CLAFORAN;Cefotaxime Na
CBNumber:
CB2197478
Summenformel:
C16H16N5NaO7S2
Molgewicht:
477.45
MOL-Datei:
64485-93-4.mol

Cefotaxim-natrium Eigenschaften

Schmelzpunkt:
162-163 C
alpha 
D20 +55±2° (c = 0.8 in water)
Brechungsindex
61 ° (C=1, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit
H2O: aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.soluble
Aggregatzustand
powder
Farbe
white to yellow
PH
pH(100g/l, 25℃) : 4.5~6.5
Wasserlöslichkeit
Soluble in water.
Merck 
14,1933
BRN 
5711411
Stabilität:
Stable. Incompatible with strong oxidizing agents.
CAS Datenbank
64485-93-4
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,Xi
R-Sätze: 42/43
S-Sätze: 22-36/37-60-45-37-24
WGK Germany  2
RTECS-Nr. XI0250000
HS Code  29419000
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung P261, P285, P304+P341, P342+P311,P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P284 Atemschutz tragen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P342+P311 Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Cefotaxim-natrium Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Chemische Eigenschaften

White to pale yellow crystalline powder

Originator

Claforan,Hoechst-Roussel,W. Germany,1980

Verwenden

Broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group

Verwenden

Cephalosporin antibacterial

Verwenden

Cefotaxime sodium salt acts as a beta-lactamase resistant antibiotic. It is used as an effective antibacterial against gram-negative bacteria, with the notable exception of pseudomonas and penicillin-resistant strains of streptococcus pneumoniae. It is used to treat infections of the bones, joints, skin, respiratory tract and blood stream.

Definition

ChEBI: A cephalosporin organic sodium salt having acetoxymethyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side-groups.

Manufacturing Process

A solution of 8 g of sodium bicarbonate in about 20 ml of ethanol was progressively added to 45.55 g of pure 3-acetoxymethyl-7-[2-(2-amino-4- thiazolyl)-2-methoxyiminoacetamido]-ceph-3-eme-4-carboxylic acid in 100 ml of distilled water and another 80 ml of ethanol and 4.5 g of activated carbon were added thereto. The mixture was stirred for 5 minutes and was filtered. The filter was rinsed with ethanol and the filtrate was evaporated to dryness under reduced pressure. The residue was taken up in 100 ml of ethanol and evaporated to dryness again. The residue was dissolved in 100 ml of methanol and the solution was poured into 2 l of acetone. The mixture was vigorously stirred and was vacuum filtered. The recovered product was rinsed with acetone and then ether and dried under reduced pressure to obtain 43.7 g of a white product which rehydrated in air to obtain a final weight of 45.2 g of sodium 3-acetoxymethyl-7-[2-(2-amino-4-thiazolyl)-2- methoxyiminoacetamido]-ceph-3-eme-4-carboxylate.

Trademarks

Claforan (Sanofi Aventis).

Therapeutic Function

Antibiotic

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

Clinical Use

Cefotaxime (Claforan) was the first third-generationcephalosporin to be introduced. It possesses excellentbroad-spectrum activity against Gram-positive and Gramnegativeaerobic and anaerobic bacteria. It is more activethan moxalactam against Gram-positive organisms. Manyβ-lactamase–producing bacterial strains are sensitive to cefotaxime,including N. gonorrhoeae, Klebsiella spp., H. influenzae,S. aureus, and E. cloacae. Some, but not all,Pseudomonas strains are sensitive. Enterococci and Listeriamonocytogenes are resistant.
The syn-isomer of cefotaxime is significantly more activethan the anti-isomer against β-lactamase–producing bacteria.This potency difference is, in part, because of greaterresistance of the syn-isomer to the action of β-lactamases.The higher affinity of the syn-isomer for PBPs, however,may also be a factor.
Cefotaxime is metabolized in part to the less active desacetylmetabolite. Approximately 20% of the metaboliteand 25% of the parent drug are excreted in the urine. Theparent drug reaches the cerebrospinal fluid in sufficient concentrationto be effective in the treatment of meningitis.Solutions of cefotaxime sodium should be used within 24hours. If stored, they should be refrigerated. Refrigerated solutionsmaintain potency up to 10 days.

Veterinary Drugs and Treatments

In the United States, there are no cefotaxime products approved for veterinary species but it has been used clinically in several species when an injectable 3rd generation cephalosporin may be indicated.

Cefotaxim-natrium Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cefotaxim-natrium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 461)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Guangzhou PI PI Biotech Inc
+8618371201331
020-81716319 sales@pipitech.com;87478684@qq.com China 3283 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5943 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58

64485-93-4(Cefotaxim-natrium)Verwandte Suche:


  • Cefotaxime:Claforan
  • FIR-756
  • (6R,7R)-7-[[(Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[(acetyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • (6R,7R)-7α-[2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetylamino]-3-(acetoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • Cefotaxime sodium salt,Cefotaxim sodium salt
  • Cefotaxime Sodium (350 mg)
  • Cefotaxime Sodium (250 mg)J0C189901ug/mg(ai)
  • Cefotaxime Sodium (250 mg)
  • CefotaxiMe sodiuM API
  • CefotaxiMe sodiuM(Claforan
  • CefotaxiMe-Na-salt research grade
  • Cefotaxime for peak identification
  • AXIME SODIUM SALT
  • Cefotaxime Sodium for Injection
  • CEFOTAXIME NA-SALT
  • CEFOTAXIME SODIUM
  • CEFOTAXIME SODIUM SALT
  • CEFOTAXIM SODIUM SALT
  • CLAFORAN
  • ctx
  • Cefotaxime, Sodium Salt, High Purity, Cell Culture-Tested
  • (((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxo-,(6r-(6-alpha,7-beta
  • (z))),sodiumsalt
  • 2,0)oct-2-ene-2-carboxylicacid,3-((acetyloxy)methyl)-7-5-thia-1-azabicyclo(
  • 5-Thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylicacid,3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-,[6R-(6-.alpha.,7-.beta.(Z))],sodiumsalt
  • hr756
  • ru24756
  • sodium7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate
  • sodium salt of 7-[2-(2-amino-4-thiazolyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 7 (Z)-(O-methyloxime), acetate (ester)
  • CEFOTAXIME SODIUM STERILE
  • sodium [6R-[6alpha,7beta(Z)]]-3-(acetoxymethyl)-7-[(2-aminothiazol-4-yl)(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • 7-[2-(2-AMINO-4-THIAZOLYL)GLYOXYLAMIDO]-3-(HYDROXYMETHYL)-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE 7(2)-(Z)-(O-METHYLOXIME) ACETATE, NA
  • [6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt
  • Cefotaxime sodium sterile USP/EP/JP
  • 5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 3-(acetyloxy)methyl-7-(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetylamino-8-oxo-, monosodium salt, (6R,7R)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-, monosodium salt, [6R-[6α,7β(Z)]]-
  • Cefotax
  • Chemcef
  • Pretor
  • Sodium cefotaxime
  • Tolycar
  • Cefotaxime Na
  • Cefotaxime free acid
  • Cefotaxime sodium sterile IP/Bp
  • CEFOTAXIME, SODIUM PLANT CELLCULTURE TES TED
  • CefotaximeSodiumSterileUsp24
  • (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Sodium Salt
  • [6R-[6α,7β(Z)]]-3-[(Acetyloxy)methyl]-7-[2-(2-amino-4-thiazolvl)-2-(methoxyimino)aeetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • Sodium salt (syn-isomer)
  • Cefotaxime (Drug Substance)
  • Ceftazidime Solution, 100ppm
  • Cefotaxime sodium salt, 92%, a third-generation cephalosporin antibiotic
  • Pharmaceutical Raw Material Cefotaxime Sodium Cas:64485-93-4
  • ([6R-[6alpha,7beta(z)]]-3-[(Acetyloxy)methyl]-[[(2-amine-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid monosodium salt
  • Cefotaxime sodium salt, ≥98%(HPLC)
  • sodium (6R,7R)-3-[(acetyloxy)methyl]-7-[2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • HR-756 (sodium salt)
  • Cefotaxime for peak identification CRS
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