Quinolinic acid

CAS No.
89-00-9
Chemical Name:
Quinolinic acid
Synonyms
PYRIDINE-2,3-DICARBOXYLIC ACID;2,3-PYRIDINEDICARBOXYLIC ACID;QUIN;2,3-Pyridinedicarboxylic;Pyridine-2,3-dicarboxylate;2,3-PyridinedicarboxylicAcid99%;109/KG;NSC 18836;NSC 13127;NSC 403247
CBNumber:
CB7316162
Molecular Formula:
C7H5NO4
Molecular Weight:
167.12
MDL Number:
MFCD00006295
MOL File:
89-00-9.mol
Last updated:2023-09-22 17:54:45

Quinolinic acid Properties

Melting point 188-190 °C (dec.) (lit.)
Boiling point 295.67°C (rough estimate)
Density 1.5216 (rough estimate)
refractive index 1.6280 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 10g/l
form Crystalline Powder
pka 2.43(at 25℃)
color White to light yellow-beige
Odor odorless
Water Solubility 0.55 g/100 mL
Merck 14,8073
BRN 137110
InChIKey GJAWHXHKYYXBSV-UHFFFAOYSA-N
CAS DataBase Reference 89-00-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII F6F0HK1URN
EPA Substance Registry System 2,3-Pyridinedicarboxylic acid (89-00-9)

SAFETY

Risk and Safety Statements

NFPA 704
0
2 0

Quinolinic acid price More Price(49)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P63204 2,3-Pyridinedicarboxylic acid 99% 89-00-9 25g $30.2 2023-06-20 Buy
Sigma-Aldrich P63204 2,3-Pyridinedicarboxylic acid 99% 89-00-9 100g $83.6 2023-06-20 Buy
TCI Chemical P0550 2,3-Pyridinedicarboxylic Acid >98.0%(GC)(T) 89-00-9 25g $25 2023-06-20 Buy
TCI Chemical P0550 2,3-Pyridinedicarboxylic Acid >98.0%(GC)(T) 89-00-9 500g $199 2023-06-20 Buy
Alfa Aesar A11414 Pyridine-2,3-dicarboxylic acid, 99% 89-00-9 25g $25.6 2023-06-20 Buy
Product number Packaging Price Buy
P63204 25g $30.2 Buy
P63204 100g $83.6 Buy
P0550 25g $25 Buy
P0550 500g $199 Buy
A11414 25g $25.6 Buy

Quinolinic acid Chemical Properties,Uses,Production

Chemical Properties

White powder;Light yellow powder

Uses

Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an ?excitotoxic? metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.

Uses

A matabolite of tryptophan and a putative NMDA receptor agonist.

Uses

An inhibitor of glucose synthesis.

Uses

Inhibits glucose synthesis

Definition

ChEBI: Quinolinic acid is a pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan. It has a role as a NMDA receptor agonist, a human metabolite, a mouse metabolite and an Escherichia coli metabolite. It is a conjugate acid of a quinolinate(1-) and a quinolinate.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 3020, 1949 DOI: 10.1021/ja01177a021

Hazard

A poison by skin contact. Moderately toxic by ingestion. A mild skin irritant.

Industrial uses

The use of quinolinic acid during flotation of hematite results in the adsorption of quinoline on hematite, allowing amine to selectively adsorb onto the hematite surface.

Biological Activity

Endogenous NMDA agonist and transmitter candidate. May distinguish between NMDA receptor subtypes.

Safety Profile

A poison by skin contact. Moderately toxic by ingestion. Experimental reproductive effects. A mdd skinn irritant. When heated to decomposition it emits toxic vapors of NOx.

storage

Room temperature

Quinolinic acid Preparation Products And Raw materials

Raw materials

Preparation Products